MCMBP and MCM5

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology, biochemical, cross-linking study)

		MCMBP	MCM5
Description		minichromosome maintenance complex binding protein	minichromosome maintenance complex component 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Cell Junction MCM Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Membrane MCM Complex CMG Complex
	Molecular Function	Chromatin Binding Protein Binding	Nucleotide Binding DNA Binding DNA Replication Origin Binding Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity 3'-5' DNA Helicase Activity
	Biological Process	DNA Replication DNA-templated DNA Replication Sister Chromatid Cohesion Cell Division	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of DNA-templated DNA Replication Initiation
Pathways			Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Height ( 28552196)	Chronotype ( 30696823) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		14 interacting genes: ASL DBF4 DDIT3 FKBP5 KEAP1 MCM3 MCM4 MCM5 MCM6 PRTFDC1 RWDD2A SNW1 USP7 ZNF474	30 interacting genes: APP ATRIP CDC5L CDC7 CDKN2A CEBPA EP300 ESCO2 FBXO7 KRTAP10-7 LMNA MCM2 MCM3 MCM7 MCMBP MCPH1 MDFI NFKBIA NUDT3 ORC1 ORC2 ORC3 ORC5 ORC6 PTEN RBPMS RPA2 STAT1 TRIM28 YWHAG
Entrez ID		79892	4174
HPRD ID		07624	04075
Ensembl ID		ENSG00000197771	ENSG00000100297
Uniprot IDs		A0A0S2Z5P5 Q9BTE3	B1AHB0 P33992
PDB IDs		4KG9	6XTX 6XTY 7PFO 7PLO 7W1Y 7W68 8B9D 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 9CAQ
Enriched GO Terms of Interacting Partners?		CMG Complex Double-strand Break Repair Via Break-induced Replication MCM Complex Regulation Of DNA-templated DNA Replication Initiation DNA Replication Initiation Regulation Of DNA Replication DNA Replication Single-stranded DNA Helicase Activity DNA Damage Response Regulation Of DNA Metabolic Process Single-stranded DNA Binding Helicase Activity Mitotic DNA Replication Initiation Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To Stress Chromosome, Telomeric Region DNA Metabolic Process Double-strand Break Repair DNA Recombination DNA Repair DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Chromosome ATP Hydrolysis Activity Nucleobase-containing Compound Metabolic Process DNA Helicase Activity Transcription Regulator Inhibitor Activity Nucleic Acid Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Argininosuccinate Lyase Activity Ammonia Assimilation Cycle Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Nucleoplasm L-arginine Biosynthetic Process Via Ornithine Nitrogen Utilization Negative Regulation Of Determination Of Dorsal Identity Response To Stress Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction CHOP-ATF4 Complex CHOP-ATF3 Complex Dbf4-dependent Protein Kinase Complex Hypoxanthine Phosphoribosyltransferase Activity Guanine Salvage CHOP-C/EBP Complex Diaphragm Contraction Vascular Associated Smooth Muscle Cell Migration Single-stranded 3'-5' DNA Helicase Activity Mitotic DNA Replication Symbiont-mediated Disruption Of Host Cell PML Body	DNA Replication Initiation Nuclear Origin Of Replication Recognition Complex DNA Replication Origin Recognition Complex DNA Metabolic Process Nucleoplasm Nucleic Acid Metabolic Process DNA Replication Origin Binding Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process Chromosome, Telomeric Region Regulation Of DNA Replication Nucleobase-containing Compound Metabolic Process MCM Complex Double-strand Break Repair Via Break-induced Replication Regulation Of Primary Metabolic Process Cellular Response To Stress Macromolecule Metabolic Process Response To Stress Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle DNA Repair Regulation Of Protein Localization To Nucleus DNA Damage Response Regulation Of Cell Cycle Phase Transition CMG Complex Regulation Of Cell Cycle Chromatin Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition Regulation Of DNA-templated DNA Replication Initiation Regulation Of Cell Cycle Process DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Single-stranded DNA Helicase Activity Recombinational Repair Negative Regulation Of Cell Cycle Process Protein Localization To Organelle Mitotic DNA Replication Initiation Identical Protein Binding Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Intracellular Signal Transduction NF-kappaB Binding Regulation Of Protein Stability Single-stranded DNA Binding Negative Regulation Of DNA-templated Transcription
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