GSDMD and ZNF558

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GSDMD	ZNF558
Description		gasdermin D	zinc finger protein 558
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Mitochondrial Membrane Specific Granule Lumen Canonical Inflammasome Complex NLRP3 Inflammasome Complex Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Nucleus
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Wide Pore Channel Activity Phosphatidylinositol-4-phosphate Binding Phosphatidic Acid Binding Cardiolipin Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Plasma Membrane Repair Immune System Process Inflammatory Response Protein Secretion Programmed Cell Death Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-18 Production Interleukin-18-mediated Signaling Pathway Defense Response To Bacterium NLRP3 Inflammasome Complex Assembly Innate Immune Response Ceramide Biosynthetic Process Pore Complex Assembly Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Protein Homooligomerization Protein Maturation Transmembrane Transport Pyroptotic Inflammatory Response Interleukin-1-mediated Signaling Pathway Pyroptotic Cell Death	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		Release of apoptotic factors from the mitochondria Interleukin-1 processing Pyroptosis Regulation of TLR by endogenous ligand Neutrophil degranulation Purinergic signaling in leishmaniasis infection CASP4-mediated substrate cleavage CASP5-mediated substrate cleavage	Generic Transcription Pathway
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Monocyte count ( 32888494) Schizophrenia ( 31268507)
Interacting Genes		9 interacting genes: ASPG CASP1 KCTD6 MEOX2 MFHAS1 PSMA1 ZBTB33 ZNF426 ZNF558	13 interacting genes: APOE CLK2 CSNK2A1 EFEMP2 EIF1AD EXOSC5 GSDMD HEXIM2 LZIC MAD2L2 MFAP1 TIAM1 UBTFL1
Entrez ID		79792	148156
HPRD ID		11014	15841
Ensembl ID		ENSG00000104518	ENSG00000167785
Uniprot IDs		P57764	Q96NG5
PDB IDs		5NH1 5WQT 6AO4 6KN0 6N9O 6VFE 7Z1X
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Phospholipid Efflux Artery Development Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Negative Regulation Of DNA Repair Negative Regulation Of DNA Recombination Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Microfibril DNA Damage Response, Signal Transduction Resulting In Transcription Positive Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Cell Cycle Process Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle Regulation Of Chromosome Separation Positive Regulation Of Aortic Smooth Muscle Cell Differentiation
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