ZNF558 and EIF1AD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF558	EIF1AD
Description		zinc finger protein 558	eukaryotic translation initiation factor 1A domain containing
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	RNA Binding Translation Initiation Factor Activity Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Translational Initiation
Pathways		Generic Transcription Pathway
Drugs
Diseases
GWAS			Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Serum uric acid levels ( 32271837)
Interacting Genes		13 interacting genes: APOE CLK2 CSNK2A1 EFEMP2 EIF1AD EXOSC5 GSDMD HEXIM2 LZIC MAD2L2 MFAP1 TIAM1 UBTFL1	34 interacting genes: AP2M1 BEND7 CCDC106 CEP55 CEP76 DPPA2 DRC4 GCSAML GLYR1 GTF2H4 LNX1 MEOX2 MID2 MREG PAX6 PBX4 PICK1 PINX1 RASSF10 RBAK RBM48 SDCBP SDCBP2 STAT1 STX11 TBC1D5 TEPSIN TLE5 TNNI1 ZBTB14 ZBTB8A ZNF280A ZNF521 ZNF558
Entrez ID		148156	84285
HPRD ID		15841	14411
Ensembl ID		ENSG00000167785	ENSG00000175376
Uniprot IDs		Q96NG5	Q8N9N8
PDB IDs			2DGY 6ZXF 6ZXG 6ZXH
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Phospholipid Efflux Artery Development Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Negative Regulation Of DNA Repair Negative Regulation Of DNA Recombination Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Microfibril DNA Damage Response, Signal Transduction Resulting In Transcription Positive Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Cell Cycle Process Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle Regulation Of Chromosome Separation Positive Regulation Of Aortic Smooth Muscle Cell Differentiation	Regulation Of Receptor Internalization Positive Regulation Of Receptor Internalization Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Receptor-mediated Endocytosis AP-2 Adaptor Complex Protein Binding
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