TXNDC15 and HLCS

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		TXNDC15	HLCS
Description		thioredoxin domain containing 15	holocarboxylase synthetase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cilium Membrane Cell Projection Ciliary Membrane	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix
	Molecular Function	Protein Binding	Nucleotide Binding Catalytic Activity Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Protein Binding ATP Binding Biotin Binding Ligase Activity Enzyme Binding Identical Protein Binding
	Biological Process	Cell Projection Organization Positive Regulation Of Smoothened Signaling Pathway Cilium Assembly	Biotin Metabolic Process Post-translational Protein Modification Response To Biotin
Pathways			Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency
Drugs			Biotin
Diseases			Holocarboxylase synthetase deficiency
GWAS		Blood protein levels ( 30072576) Height ( 18391951)	Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Seasonality and depression ( 30217971)
Interacting Genes		4 interacting genes: ASPH HLCS UBC ZDHHC17	19 interacting genes: ACACB ANKRD29 BACH1 DDX52 IFNAR2 IFNGR2 IFT20 KRTAP5-9 LANCL2 MED19 NGB POT1 QKI SARS2 SNX27 SOD1 TGM3 TXNDC15 WIPF1
Entrez ID		79770	3141
HPRD ID		08658	08360
Ensembl ID		ENSG00000113621	ENSG00000159267
Uniprot IDs		Q96J42	A0A8C8QSB1 P50747
PDB IDs
Enriched GO Terms of Interacting Partners?		Peptidyl-aspartic Acid 3-dioxygenase Activity Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Response To Biotin Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Activation Of Store-operated Calcium Channel Activity Biotin Metabolic Process Biotin Binding Protein-cysteine S-myristoyltransferase Activity Positive Regulation Of Store-operated Calcium Channel Activity Protein-cysteine S-stearoyltransferase Activity Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Lumen Junctional Sarcoplasmic Reticulum Membrane Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cell Communication By Electrical Coupling Regulation Of Calcium Ion Transport Into Cytosol Detection Of Calcium Ion Protein Modification Process Nuclear Lamina Protein Tag Activity Lipoprotein Transport Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein Palmitoylation Palmitoyltransferase Activity Regulation Of Modification Of Synaptic Structure Golgi-associated Vesicle Membrane Protein-cysteine S-palmitoyltransferase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Positive Regulation Of Cation Channel Activity Calcium Channel Complex
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