LRRK1 and TEC

Number of citations of the paper that reports this interaction (PubMedID 29513927)
77

Data Source:
BioGRID (pull down)

		LRRK1	TEC
Description		leucine rich repeat kinase 1	tec protein tyrosine kinase
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phospholipid Binding Zinc Ion Binding Lipid Binding Kinase Activity Transferase Activity Metal Ion Binding
	Biological Process	Positive Regulation Of Signal Transduction Intracellular Signal Transduction Osteoclast Development Bone Resorption Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Signal Transduction	Adaptive Immune Response Immune System Process Protein Phosphorylation Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Intracellular Signal Transduction Tissue Regeneration T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways			Signaling by SCF-KIT FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Interleukin-3, Interleukin-5 and GM-CSF signaling
Drugs			Fostamatinib Zanubrutinib
Diseases
GWAS		Central corneal thickness ( 28171582 29760442 31798171 32528159) Corneal structure ( 23291589) Height ( 28552196) Systemic lupus erythematosus ( 33272962)	Crohn's disease ( 23128233) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Rheumatoid arthritis ( 24390342 30423114) Systolic blood pressure ( 27841878)
Interacting Genes		55 interacting genes: ABL1 BAG1 BAG2 BAG3 BAG5 BLOC1S5 C11orf52 CBLB CCL21 CD2BP2 CDC42EP3 CDK1 CDK5RAP2 CHGB CIMIP4 CKAP2 CLVS1 CPLX3 CWC15 ECHS1 EGFR ENKUR EPHA8 FAM184A FBXL14 FGFR2 FLT4 FOXP1 GAK GNAZ GPBP1L1 ITCH KIF20A MATK MTG1 NEK1 NUDT16L1 ODF2 PAK6 PDCD4 PLK1 POLR2M RAB29 RET SCEL SELENOS SH2D2A SNX21 SNX9 STUB1 TCF25 TEC TIRAP TM2D3 VGLL4	42 interacting genes: ARHGAP6 ARHGEF12 BMX BTK COMMD8 DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG FBXO7 GAB1 GABRB1 GNA12 IKBKG JAK1 JAK2 KIT LRRK1 LYN MET OTUD4 PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PRRG4 PTPN18 PTPN21 SHC1 SOCS1 STAP1 TP53 TXK VAV1 WAS
Entrez ID		79705	7006
HPRD ID		14319	02786
Ensembl ID		ENSG00000154237	ENSG00000135605
Uniprot IDs		Q38SD2	P42680
PDB IDs		8E04 8E05 8E06 8FAC	2LUL
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Protein Kinase Activity Kinase Activity Adenyl-nucleotide Exchange Factor Activity Regulation Of Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Post-translational Protein Modification Negative Regulation Of Apoptotic Process Regulation Of Protein Catabolic Process Regulation Of Protein Ubiquitination Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Catabolic Process Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Nucleotide Binding Protein-folding Chaperone Binding Positive Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Golgi Organization Regulation Of Programmed Cell Death Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Metabolic Process Regulation Of Protein-containing Complex Assembly T Cell Anergy Mitotic Cytokinesis Regulation Of Heart Growth Transferase Activity ATP Binding T Cell Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of JNK Cascade Protein Phosphorylation Positive Regulation Of T Cell Anergy T Cell Tolerance Induction Protein Folding Chaperone Complex Positive Regulation Of Protein Polymerization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cell Communication Regulation Of Signaling Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Protein Metabolic Process Phosphorylation Cytoskeleton-dependent Cytokinesis Chaperone-mediated Autophagy Regulation Of Organ Growth Regulation Of Signal Transduction Regulation Of T Cell Anergy	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Signal Transduction Regulation Of Signal Transduction Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Protein Kinase Activity Phosphotyrosine Residue Binding Positive Regulation Of Intracellular Signal Transduction Lymphocyte Activation Cellular Developmental Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Mononuclear Cell Differentiation Regulation Of Programmed Cell Death Cytosol Protein Phosphorylation Leukocyte Activation ERBB Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Leukocyte Differentiation Phosphorylation Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Fc-epsilon Receptor Signaling Pathway Cell Activation Developmental Process Fc Receptor Signaling Pathway Lymphocyte Differentiation Regulation Of Immune System Process Regulation Of Locomotion Immune System Process B Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Regulation Of Immune Response Phosphatidylinositol Metabolic Process T Cell Activation ATP Binding Positive Regulation Of Immune System Process
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