GALNT12 and MUC5AC

Number of citations of the paper that reports this interaction (PubMedID 12135769)
0

Data Source:
BioGRID (enzymatic study)

		GALNT12	MUC5AC
Description		polypeptide N-acetylgalactosaminyltransferase 12	mucin 5AC, oligomeric mucus/gel-forming
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GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane	Extracellular Region Extracellular Space Golgi Lumen Plasma Membrane Extracellular Matrix Extracellular Exosome Mucus Layer
	Molecular Function	Polypeptide N-acetylgalactosaminyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Carbohydrate Binding Metal Ion Binding	Extracellular Matrix Structural Constituent Metal Ion Binding
	Biological Process	Protein Glycosylation Protein O-linked Glycosylation Protein O-linked Glycosylation Via N-acetyl-galactosamine
Pathways		Defective GALNT12 causes CRCS1 O-linked glycosylation of mucins	Defective GALNT3 causes HFTC Defective C1GALT1C1 causes TNPS Defective GALNT12 causes CRCS1 Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis
Drugs
Diseases
GWAS		Asthma ( 31959851) Autism spectrum disorder ( 34069769) Brain morphology (MOSTest) ( 32665545) FEV1 ( 30804560) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) joint destruction in rheumatoid arthritis (rapid vs slow) ( 33585033) Left–right brain asymmetry ( 33723403) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560) Serum galactose-deficient IgA1 levels in IgA nephropathy ( 33593824)	Asthma ( 31959851 34103634) Asthma (adult onset) ( 31036433) Asthma (moderate or severe) ( 30552067) Idiopathic pulmonary fibrosis ( 24429156)
Interacting Genes		16 interacting genes: APP BMPR1A BUB1 CDH1 CDKN2A FBXW7 MLH3 MSH2 MUC1 MUC2 MUC5AC MUC7 PIK3CA PMS2 RB1 SRC	2 interacting genes: GALNT12 GALNT14
Entrez ID		79695	4586
HPRD ID		13561
Ensembl ID		ENSG00000119514	ENSG00000215182
Uniprot IDs		Q8IXK2	P98088
PDB IDs		6PXU	5AJN 5AJO 5AJP 8OV0 8QSP 8QTB 8QTV 8R1U 8R1Z 8UI6 8UJF 8V9Q 9GVJ 9GVQ
Enriched GO Terms of Interacting Partners?		Golgi Lumen Mismatched DNA Binding Regulation Of Mitotic Cell Cycle ATP-dependent DNA Damage Sensor Activity Regulation Of Apoptotic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Regulation Of Cell Cycle Phase Transition Mismatch Repair Negative Regulation Of Cell Development Homeostatic Process Regulation Of Growth Regulation Of Developmental Process Regulation Of Protein Localization To Nucleus Chromosome Organization Positive Regulation Of Isotype Switching To IgA Isotypes Centromeric DNA Binding Mismatch Repair Complex Negative Regulation Of Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Signaling Receptor Activator Activity Regulation Of Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Biosynthetic Process Regulation Of Immune System Process Regulation Of Cell Cycle Process Cellular Response To Stress Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Protein Localization Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Cell Cycle Phase Transition Somatic Hypermutation Of Immunoglobulin Genes Regulation Of Multicellular Organismal Process Regulation Of Neuron Apoptotic Process Somatic Diversification Of Immune Receptors Via Somatic Mutation Intracellular Signal Transduction Regulation Of Isotype Switching To IgG Isotypes Cellular Response To Oxygen-containing Compound Positive Regulation Of Developmental Process Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization Response To Stress ATP Binding Negative Regulation Of Anoikis Negative Regulation Of Macromolecule Metabolic Process	Polypeptide N-acetylgalactosaminyltransferase Activity Protein O-linked Glycosylation Via N-acetyl-galactosamine Protein O-linked Glycosylation Protein Glycosylation Glycosylation Macromolecule Glycosylation Carbohydrate Binding Glycosyltransferase Activity Glycoprotein Biosynthetic Process Glycoprotein Metabolic Process Carbohydrate Derivative Biosynthetic Process Golgi Membrane Carbohydrate Derivative Metabolic Process Golgi Apparatus Macromolecule Biosynthetic Process Protein Modification Process Transferase Activity Protein Metabolic Process
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