SMC6 and SLF2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (pull down, pull down, affinity chromatography technology)

		SMC6	SLF2
Description		structural maintenance of chromosomes 6	SMC5/6 complex localization factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromosome, Telomeric Region Sex Chromosome Nucleus Nucleoplasm Chromosome PML Body Nuclear Speck Smc5-Smc6 Complex Interchromatin Granule Site Of Double-strand Break Mitotic Spindle Pole Chromosomal Region	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm PML Body Smc5-Smc6 Complex Site Of Double-strand Break
	Molecular Function	Nucleotide Binding DNA Secondary Structure Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding	Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding
	Biological Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair DNA Recombination DNA Damage Response Protein Sumoylation Regulation Of Telomere Maintenance Host-mediated Suppression Of Viral Genome Replication Positive Regulation Of Chromosome Segregation Cellular Senescence Chromatin Looping	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Damage Response Protein Sumoylation Positive Regulation Of Protein-containing Complex Assembly Regulation Of Telomere Maintenance Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Chromatin Looping Protein Localization To Site Of Double-strand Break Positive Regulation Of Double-strand Break Repair
Pathways		SUMOylation of DNA damage response and repair proteins
Drugs
Diseases
GWAS		LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Total cholesterol levels ( 30275531)	Age at first birth ( 34211149) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung cancer ( 28604730)
Interacting Genes		1 interacting genes: SLF2	7 interacting genes: CALM1 CBS OPTN PSMA1 SFMBT2 SMC6 TRIM14
Entrez ID		79677	55719
HPRD ID		10242	12581
Ensembl ID		ENSG00000163029	ENSG00000119906
Uniprot IDs		A0A2S1ZR87 Q96SB8	Q8IX21
PDB IDs			7T5P
Enriched GO Terms of Interacting Partners?		Smc5-Smc6 Complex Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Positive Regulation Of Sister Chromatid Cohesion Regulation Of Sister Chromatid Cohesion Chromatin Looping Protein Localization To Site Of Double-strand Break Protein Sumoylation Positive Regulation Of Double-strand Break Repair Protein Localization To Chromosome Site Of Double-strand Break Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance PML Body Recombinational Repair Positive Regulation Of DNA Repair Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Chromosome, Telomeric Region Positive Regulation Of Protein-containing Complex Assembly Double-strand Break Repair Regulation Of Chromosome Organization Regulation Of DNA Repair DNA Recombination Positive Regulation Of Cell Cycle Process Positive Regulation Of DNA Metabolic Process	Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Nucleus Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cysteine Biosynthetic Process Cysteine Biosynthetic Process From Serine L-serine Catabolic Process Transsulfuration Cysteine Biosynthetic Process Via Cystathionine Homocysteine Catabolic Process Hydrogen Sulfide Biosynthetic Process Nitrite Reductase (NO-forming) Activity Cerebellum Morphogenesis Hydrogen Sulfide Metabolic Process L-cysteine Catabolic Process Cystathionine Beta-synthase Activity Nitric Oxide Binding Carbon Monoxide Binding Negative Regulation Of Receptor Recycling Type 2 Mitophagy DNA Secondary Structure Binding Interchromatin Granule Chromosomal Region Sex Chromosome Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Autophagosome Membrane Docking DNA Protection Modified Amino Acid Binding Negative Regulation Of Voltage-gated Calcium Channel Activity Proteasome Core Complex, Alpha-subunit Complex Positive Regulation Of Xenophagy Smc5-Smc6 Complex Regulation Of Nitric Oxide Mediated Signal Transduction Response To Folic Acid Golgi Ribbon Formation Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Sulfur Amino Acid Catabolic Process Cysteine Metabolic Process Serine Family Amino Acid Catabolic Process
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