SLF2 and SMC6

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (pull down, pull down, affinity chromatography technology)

		SLF2	SMC6
Description		SMC5/6 complex localization factor 2	structural maintenance of chromosomes 6
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm PML Body Smc5-Smc6 Complex Site Of Double-strand Break	Chromosome, Centromeric Region Chromosome, Telomeric Region Sex Chromosome Nucleus Nucleoplasm Chromosome PML Body Nuclear Speck Smc5-Smc6 Complex Interchromatin Granule Site Of Double-strand Break Mitotic Spindle Pole Chromosomal Region
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding	Nucleotide Binding DNA Secondary Structure Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Damage Response Protein Sumoylation Positive Regulation Of Protein-containing Complex Assembly Regulation Of Telomere Maintenance Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Chromatin Looping Protein Localization To Site Of Double-strand Break Positive Regulation Of Double-strand Break Repair	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair DNA Recombination DNA Damage Response Protein Sumoylation Regulation Of Telomere Maintenance Host-mediated Suppression Of Viral Genome Replication Positive Regulation Of Chromosome Segregation Cellular Senescence Chromatin Looping
Pathways			SUMOylation of DNA damage response and repair proteins
Drugs
Diseases
GWAS		Age at first birth ( 34211149) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung cancer ( 28604730)	LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Total cholesterol levels ( 30275531)
Interacting Genes		7 interacting genes: CALM1 CBS OPTN PSMA1 SFMBT2 SMC6 TRIM14	1 interacting genes: SLF2
Entrez ID		55719	79677
HPRD ID		12581	10242
Ensembl ID		ENSG00000119906	ENSG00000163029
Uniprot IDs		Q8IX21	A0A2S1ZR87 Q96SB8
PDB IDs		7T5P
Enriched GO Terms of Interacting Partners?		Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Nucleus Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cysteine Biosynthetic Process Cysteine Biosynthetic Process From Serine L-serine Catabolic Process Transsulfuration Cysteine Biosynthetic Process Via Cystathionine Homocysteine Catabolic Process Hydrogen Sulfide Biosynthetic Process Nitrite Reductase (NO-forming) Activity Cerebellum Morphogenesis Hydrogen Sulfide Metabolic Process L-cysteine Catabolic Process Cystathionine Beta-synthase Activity Nitric Oxide Binding Carbon Monoxide Binding Negative Regulation Of Receptor Recycling Type 2 Mitophagy DNA Secondary Structure Binding Interchromatin Granule Chromosomal Region Sex Chromosome Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Autophagosome Membrane Docking DNA Protection Modified Amino Acid Binding Negative Regulation Of Voltage-gated Calcium Channel Activity Proteasome Core Complex, Alpha-subunit Complex Positive Regulation Of Xenophagy Smc5-Smc6 Complex Regulation Of Nitric Oxide Mediated Signal Transduction Response To Folic Acid Golgi Ribbon Formation Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Sulfur Amino Acid Catabolic Process Cysteine Metabolic Process Serine Family Amino Acid Catabolic Process	Smc5-Smc6 Complex Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Positive Regulation Of Sister Chromatid Cohesion Regulation Of Sister Chromatid Cohesion Chromatin Looping Protein Localization To Site Of Double-strand Break Protein Sumoylation Positive Regulation Of Double-strand Break Repair Protein Localization To Chromosome Site Of Double-strand Break Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance PML Body Recombinational Repair Positive Regulation Of DNA Repair Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Chromosome, Telomeric Region Positive Regulation Of Protein-containing Complex Assembly Double-strand Break Repair Regulation Of Chromosome Organization Regulation Of DNA Repair DNA Recombination Positive Regulation Of Cell Cycle Process Positive Regulation Of DNA Metabolic Process
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