NEIL1 and XRCC1

Number of citations of the paper that reports this interaction (PubMedID 15260972)
0

Data Source:
HPRD (in vitro)

		NEIL1	XRCC1
Description		nei like DNA glycosylase 1	X-ray repair cross complementing 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Nucleolus ERCC4-ERCC1 Complex Site Of DNA Damage
	Molecular Function	Nucleic Acid Binding DNA Binding Damaged DNA Binding Catalytic Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Lyase Activity DNA N-glycosylase Activity Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity	Damaged DNA Binding Protein Binding Enzyme Binding Oxidized DNA Binding Poly-ADP-D-ribose Binding ADP-D-ribose Modification-dependent Protein Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity
	Biological Process	DNA Repair Base-excision Repair Base-excision Repair, Gap-filling DNA Damage Response Response To Oxidative Stress Negative Regulation Of Nuclease Activity Depyrimidination	Single Strand Break Repair DNA Repair Base-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Negative Regulation Of Protein ADP-ribosylation Hippocampus Development Response To Hydroperoxide Telomeric DNA-containing Double Minutes Formation Regulation Of Base-excision Repair Negative Regulation Of Protection From Non-homologous End Joining At Telomere
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Defective Base Excision Repair Associated with NEIL1	Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway HDR through MMEJ (alt-NHEJ) Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs		Iron Copper Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases
GWAS			Apolipoprotein B levels ( 32203549) Height ( 31562340) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457)
Interacting Genes		6 interacting genes: APP HUS1 MAP3K11 POLB RAD1 XRCC1	22 interacting genes: ANXA1 APEX1 APLF APTX BRCA1 BTRC CHEK2 CSNK2A1 CSNK2A2 LIG3 NEIL1 OGG1 PARP1 PARP2 PCNA PNKP POLB PSMD8 RNF146 TOPORS UBE2I UHRF2
Entrez ID		79661	7515
HPRD ID		12314	01909
Ensembl ID		ENSG00000140398	ENSG00000073050
Uniprot IDs		Q96FI4	B2RCY5 P18887 Q59HH7
PDB IDs		1TDH 4NRV 5ITQ 5ITR 5ITT 5ITU 5ITX 5ITY 6LWA 6LWB 6LWC 6LWD 6LWF 6LWG 6LWH 6LWI 6LWJ 6LWK 6LWL 6LWM 6LWN 6LWO 6LWP 6LWQ 6LWR 7TMX 8FTJ	1CDZ 1XNA 1XNT 2D8M 2W3O 3K75 3K77 3LQC 5E6Q 5W7X 5W7Y 6WH1 6WH2
Enriched GO Terms of Interacting Partners?		Checkpoint Clamp Complex Damaged DNA Binding Meiotic Cell Cycle Checkpoint Signaling Response To Radiation DNA Repair Response To Ionizing Radiation Intracellular Signal Transduction DNA Metabolic Process Double-strand Break Repair DNA Damage Response DNA Recombination Base-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Enzyme Binding Positive Regulation Of Neuron Apoptotic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To Ionizing Radiation Oxidized DNA Binding Positive Regulation Of JNK Cascade Macromolecule Metabolic Process Telomere Maintenance DNA Damage Checkpoint Signaling Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Stress Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cellular Response To Stress Telomere Organization Meiotic DNA Integrity Checkpoint Signaling Immunoglobulin Heavy Chain V-D-J Recombination Meiotic Recombination Checkpoint Signaling ADP-D-ribose Modification-dependent Protein Binding Telomeric DNA-containing Double Minutes Formation Negative Regulation Of Protein ADP-ribosylation Negative Regulation Of Protection From Non-homologous End Joining At Telomere Regulation Of JNK Cascade Signal Transduction In Response To DNA Damage	Damaged DNA Binding DNA Repair DNA Damage Response DNA Metabolic Process Base-excision Repair, Gap-filling Nucleoplasm Double-strand Break Repair Macromolecule Metabolic Process Cellular Response To Stress Base-excision Repair Nucleic Acid Metabolic Process Nucleus DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Nucleobase-containing Compound Metabolic Process Response To Stress Double-strand Break Repair Via Nonhomologous End Joining DNA Modification Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Poly-ADP-D-ribose Binding Catalytic Activity Regulation Of DNA Metabolic Process Transferase Activity Regulation Of DNA Repair Post-translational Protein Modification DNA Recombination Response To Radiation NAD+-protein-serine ADP-ribosyltransferase Activity Polynucleotide 3'-phosphatase Activity SUMO Transferase Activity DNA Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process DNA Repair-dependent Chromatin Remodeling DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Protein Kinase CK2 Complex Response To Oxidative Stress Chromatin Organization Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding Protein Localization To Chromosome PML Body Chromatin Remodeling Protein Modification Process Chromosome Protein Modification By Small Protein Conjugation Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process
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