XRCC1 and ANXA1

Number of citations of the paper that reports this interaction (PubMedID 37001908)
48

Data Source:
BioGRID (unspecified method)

		XRCC1	ANXA1
Description		X-ray repair cross complementing 1	annexin A1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Nucleolus ERCC4-ERCC1 Complex Site Of DNA Damage	Cornified Envelope Phagocytic Cup Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Actin Filament Plasma Membrane Adherens Junction Focal Adhesion Cilium Cell Surface Endosome Membrane Vesicle Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Cytoplasmic Vesicle Membrane Extracellular Matrix Cytoplasmic Vesicle Motile Cilium Early Endosome Membrane Vesicle Sarcolemma Cell Projection Extracellular Exosome
	Molecular Function	Damaged DNA Binding Protein Binding Enzyme Binding Oxidized DNA Binding Poly-ADP-D-ribose Binding ADP-D-ribose Modification-dependent Protein Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity	Phosphatidylserine Binding Phospholipase Inhibitor Activity Signaling Receptor Binding Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding Lipid Binding Phospholipase A2 Inhibitor Activity Metal Ion Binding Calcium-dependent Protein Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Single Strand Break Repair DNA Repair Base-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Negative Regulation Of Protein ADP-ribosylation Hippocampus Development Response To Hydroperoxide Telomeric DNA-containing Double Minutes Formation Regulation Of Base-excision Repair Negative Regulation Of Protection From Non-homologous End Joining At Telomere	Neutrophil Homeostasis Adaptive Immune Response Immune System Process Monocyte Chemotaxis Regulation Of Leukocyte Migration Phagocytosis Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Cell Shape Myoblast Migration Involved In Skeletal Muscle Regeneration Peptide Cross-linking Actin Cytoskeleton Organization Keratinocyte Differentiation Positive Regulation Of Vesicle Fusion Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Neutrophil Apoptotic Process Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of T Cell Proliferation Neutrophil Activation Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Exocytosis Alpha-beta T Cell Differentiation Regulation Of Hormone Secretion Arachidonate Secretion Regulation Of Inflammatory Response Negative Regulation Of Transport Positive Regulation Of Multicellular Organismal Process Cellular Response To Glucocorticoid Stimulus Granulocyte Chemotaxis Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Wound Healing Neutrophil Clearance Cell-cell Adhesion Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway HDR through MMEJ (alt-NHEJ) Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER	G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands Smooth Muscle Contraction Interleukin-4 and Interleukin-13 signaling Developmental Lineage of Pancreatic Ductal Cells
Drugs			Amcinonide Fluocinolone acetonide Hydrocortisone Methylprednisolone Clobetasol propionate Budesonide Dexamethasone Cortisone acetate Hydrocortisone aceponate Hydrocortisone acetate Hydrocortisone butyrate Hydrocortisone cypionate Hydrocortisone phosphate Hydrocortisone probutate Hydrocortisone valerate Prednisolone phosphate Dexamethasone acetate Betamethasone phosphate
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Height ( 31562340) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457)	Chronotype ( 30696823) Cortical surface area ( 32963231) Cortical volume ( 32963231) Metabolite levels ( 23823483) Parkinson's disease ( 26227905) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Urate levels in obese individuals ( 25811787)
Interacting Genes		22 interacting genes: ANXA1 APEX1 APLF APTX BRCA1 BTRC CHEK2 CSNK2A1 CSNK2A2 LIG3 NEIL1 OGG1 PARP1 PARP2 PCNA PNKP POLB PSMD8 RNF146 TOPORS UBE2I UHRF2	80 interacting genes: AP2A2 APBB1 BUB3 CCN1 CCT7 CD274 CD44 CDC5L CDH13 CLIC1 CLTC COPS6 CORO1C CSAD CZIB DAPK3 DDB1 DDX3X DYSF EEF2 EGFR EIF2S1 EPHA2 ERG28 FAF1 FGFBP1 FLOT1 FLOT2 FPR1 G3BP2 GAPDH GAPDHS GNL3 HMGA1 HSP90AB1 HSPB1 IFIT1 IFIT3 IGF2BP1 IGF2BP3 KLHL23 KMT2B KRT8 LGALS3 LGALS8 LMNA LMO7 LNPK LRIF1 MEIS2 MEN1 MYBBP1A MYH10 MYH9 NOP58 OTUB1 PARP1 PARP9 PHB2 PRKCI RCC2 S100A11 SRC STRAP SUMO2 TCP1 TGM2 TOE1 TRAF4 TRPM7 UBE2D1 UBE2I UBE3A UCHL5 UGDH UNC119 USP7 XRCC1 XRCC6 YWHAQ
Entrez ID		7515	301
HPRD ID		01909	01060
Ensembl ID		ENSG00000073050	ENSG00000135046
Uniprot IDs		B2RCY5 P18887 Q59HH7	P04083 Q5TZZ9
PDB IDs		1CDZ 1XNA 1XNT 2D8M 2W3O 3K75 3K77 3LQC 5E6Q 5W7X 5W7Y 6WH1 6WH2	1AIN 1BO9 1QLS 5VFW
Enriched GO Terms of Interacting Partners?		Damaged DNA Binding DNA Repair DNA Damage Response DNA Metabolic Process Base-excision Repair, Gap-filling Nucleoplasm Double-strand Break Repair Macromolecule Metabolic Process Cellular Response To Stress Base-excision Repair Nucleic Acid Metabolic Process Nucleus DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Nucleobase-containing Compound Metabolic Process Response To Stress Double-strand Break Repair Via Nonhomologous End Joining DNA Modification Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Poly-ADP-D-ribose Binding Catalytic Activity Regulation Of DNA Metabolic Process Transferase Activity Regulation Of DNA Repair Post-translational Protein Modification DNA Recombination Response To Radiation NAD+-protein-serine ADP-ribosyltransferase Activity Polynucleotide 3'-phosphatase Activity SUMO Transferase Activity DNA Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process DNA Repair-dependent Chromatin Remodeling DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Protein Kinase CK2 Complex Response To Oxidative Stress Chromatin Organization Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding Protein Localization To Chromosome PML Body Chromatin Remodeling Protein Modification Process Chromosome Protein Modification By Small Protein Conjugation Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process	Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Focal Adhesion Negative Regulation Of Macromolecule Metabolic Process Regulation Of Telomere Maintenance Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Cytosol Nucleus RNA Binding Positive Regulation Of Protein Localization Negative Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Cytoplasm Extracellular Exosome MRNA 5'-UTR Binding Positive Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Chromosome Organization Regulation Of Protein Modification Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Regulation Of DNA Metabolic Process Regulation Of Programmed Cell Death Regulation Of Protein Localization Regulation Of Cell Adhesion Perinuclear Region Of Cytoplasm Biological Process Involved In Interaction With Host Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Macromolecule Biosynthetic Process Signal Transduction Cellular Response To Stress Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Lamellipodium Negative Regulation Of Protein Metabolic Process Regulation Of Signaling Intracellular Signal Transduction Response To Stress Regulation Of Gene Expression Disordered Domain Specific Binding Flotillin Complex Protein Binding
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