RHBDF2 and TRIM31

Number of citations of the paper that reports this interaction (PubMedID 35217669)
37

Data Source:
BioGRID (pull down, pull down, enzymatic study)

		RHBDF2	TRIM31
Description		rhomboid 5 homolog 2	tripartite motif containing 31
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Lumen Plasma Membrane Endomembrane System Membrane	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Growth Factor Binding Protein Transporter Activity	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Protein Transport Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Secretion Negative Regulation Of Protein Secretion Protein Localization To Plasma Membrane	Immune System Process Ubiquitin-dependent Protein Catabolic Process Inflammatory Response Protein Ubiquitination Viral Release From Host Cell Negative Regulation Of Viral Transcription NLRP3 Inflammasome Complex Assembly Innate Immune Response Positive Regulation Of DNA-templated Transcription Host-mediated Suppression Of Symbiont Invasion Defense Response To Virus Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Antiviral Innate Immune Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly
Pathways		CD163 mediating an anti-inflammatory response	Interferon gamma signaling
Drugs
Diseases
GWAS		Eosinophil count ( 32888494) Mean corpuscular volume ( 32888494)	Anger ( 24489884) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Beta-2 microglubulin plasma levels ( 23417110) Chronic obstructive pulmonary disease ( 33909500) Estimated glomerular filtration rate in diabetes ( 31451708) Haemorrhoidal disease ( 33888516) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Isovolumetric relaxation time ( 28394258) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 27863252) Neuroticism ( 29255261) Prostate cancer ( 25217961) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systemic lupus erythematosus ( 32771030) Takayasu arteritis ( 33308445) Type 1 diabetes and autoimmune thyroid diseases ( 25936594)
Interacting Genes		2 interacting genes: STUB1 TRIM31	27 interacting genes: BTNL2 CCT6A CFLAR EID3 IKBKG MAGEA1 MAGEA2B MAVS MKRN3 MNAT1 NSMCE4A RHBDF2 SYK TRAF2 TRIM23 TRIM27 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2K UBE2L3 UBE2N UBE2W USP7 ZSCAN1
Entrez ID		79651	11074
HPRD ID		07987	10281
Ensembl ID		ENSG00000129667	ENSG00000204616
Uniprot IDs		Q6PJF5	Q2L6J1 Q9BZY9
PDB IDs		8SNL 8SNM 8SNN 8SNO	2YSJ 2YSL
Enriched GO Terms of Interacting Partners?		Protein K63-linked Ubiquitination Positive Regulation Of Chaperone-mediated Protein Complex Assembly Chaperone-mediated Autophagy Protein Polyubiquitination Positive Regulation Of ERAD Pathway Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Modification-dependent Protein Catabolic Process Ubiquitin-ubiquitin Ligase Activity Nuclear Inclusion Body Regulation Of Glucocorticoid Metabolic Process Negative Regulation Of Vasoconstriction Regulation Of Vascular Associated Smooth Muscle Contraction Negative Regulation Of Smooth Muscle Cell Apoptotic Process Ubiquitin Protein Ligase Activity Negative Regulation Of Vascular Associated Smooth Muscle Contraction Response To Misfolded Protein Cellular Response To Misfolded Protein Proteolysis Involved In Protein Catabolic Process TPR Domain Binding Regulation Of Protein-containing Complex Assembly Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Complex Positive Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Misfolded Protein Binding Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Viral Transcription Post-translational Protein Modification Regulation Of Viral Transcription Negative Regulation Of Muscle Contraction ERBB2 Signaling Pathway NLRP3 Inflammasome Complex Assembly Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of Mitophagy Positive Regulation Of Autophagy Of Mitochondrion Regulation Of ERAD Pathway Cellular Response To Topologically Incorrect Protein R-SMAD Binding Viral Release From Host Cell Macromolecule Catabolic Process Protein Folding Chaperone Complex Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Canonical Inflammasome Complex Assembly Regulation Of Hormone Metabolic Process Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Response To Endoplasmic Reticulum Stress	Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Polyubiquitination Post-translational Protein Modification Protein Ubiquitination Protein Modification Process TORC1 Signaling Protein Metabolic Process TOR Signaling Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination Transferase Activity Negative Regulation Of TORC1 Signaling Protein K63-linked Ubiquitination Macromolecule Metabolic Process Negative Regulation Of TOR Signaling Ubiquitin Protein Ligase Binding Regulation Of TORC1 Signaling Ubiquitin Ligase Complex Regulation Of Metabolic Process Ubiquitin Protein Ligase Activity Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Modification-dependent Protein Catabolic Process DNA Damage Response Macromolecule Catabolic Process Regulation Of TOR Signaling ATP Binding Nucleotide Binding Innate Immune Response Regulation Of Nucleobase-containing Compound Metabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Positive Regulation Of Autophagy Regulation Of Macromolecule Metabolic Process Regulation Of DNA-binding Transcription Factor Activity DNA Repair Cellular Response To Stress Defense Response To Symbiont Defense Response To Other Organism Response To Stress Nucleus Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Metabolic Process Regulation Of Telomere Maintenance Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Establishment Of Protein Localization To Telomere
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