RHBDF2

Description		rhomboid 5 homolog 2
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Lumen Plasma Membrane Endomembrane System Membrane
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Growth Factor Binding Protein Transporter Activity
	Biological Process	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Protein Transport Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Secretion Negative Regulation Of Protein Secretion Protein Localization To Plasma Membrane
Pathways		CD163 mediating an anti-inflammatory response
Drugs
Diseases
GWAS		Eosinophil count ( 32888494) Mean corpuscular volume ( 32888494)
Novel Interacting Genes		2 novel interacting genes: STUB1 TRIM31
Interacting Genes		2 interacting genes: STUB1 TRIM31
Entrez ID		79651
HPRD ID		07987
Ensembl ID		ENSG00000129667
Uniprot IDs		Q6PJF5
PDB IDs		8SNL 8SNM 8SNN 8SNO
Enriched GO Terms of Interacting Partners?		Protein K63-linked Ubiquitination Positive Regulation Of Chaperone-mediated Protein Complex Assembly Chaperone-mediated Autophagy Protein Polyubiquitination Positive Regulation Of ERAD Pathway Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Modification-dependent Protein Catabolic Process Ubiquitin-ubiquitin Ligase Activity Nuclear Inclusion Body Regulation Of Glucocorticoid Metabolic Process Negative Regulation Of Vasoconstriction Regulation Of Vascular Associated Smooth Muscle Contraction Negative Regulation Of Smooth Muscle Cell Apoptotic Process Ubiquitin Protein Ligase Activity Negative Regulation Of Vascular Associated Smooth Muscle Contraction Response To Misfolded Protein Cellular Response To Misfolded Protein Proteolysis Involved In Protein Catabolic Process TPR Domain Binding Regulation Of Protein-containing Complex Assembly Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Complex Positive Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Misfolded Protein Binding Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Viral Transcription Post-translational Protein Modification Regulation Of Viral Transcription Negative Regulation Of Muscle Contraction ERBB2 Signaling Pathway NLRP3 Inflammasome Complex Assembly Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of Mitophagy Positive Regulation Of Autophagy Of Mitochondrion Regulation Of ERAD Pathway Cellular Response To Topologically Incorrect Protein R-SMAD Binding Viral Release From Host Cell Macromolecule Catabolic Process Protein Folding Chaperone Complex Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Canonical Inflammasome Complex Assembly Regulation Of Hormone Metabolic Process Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Response To Endoplasmic Reticulum Stress
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