CDC73 and KCNH2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CDC73	KCNH2
Description		cell division cycle 73	potassium voltage-gated channel subfamily H member 2
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Cdc73/Paf1 Complex	Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Monoatomic Ion Channel Complex Perinuclear Region Of Cytoplasm Inward Rectifier Potassium Channel Complex
	Molecular Function	RNA Polymerase II Complex Binding Protein Binding	Transcription Cis-regulatory Region Binding Monoatomic Ion Channel Activity Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Scaffold Protein Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Endodermal Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Wnt Signaling Pathway Stem Cell Population Maintenance Positive Regulation Of Wnt Signaling Pathway MRNA 3'-end Processing Positive Regulation Of MRNA 3'-end Processing Protein Destabilization Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Apoptotic Process Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Regulation Of Heart Rate By Hormone Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Positive Regulation Of DNA-templated Transcription Potassium Ion Homeostasis Transmembrane Transport Cardiac Muscle Contraction Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To Xenobiotic Stimulus Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Depolarization During Action Potential Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Monoatomic Cation Transmembrane Transport Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Ion Import Across Plasma Membrane
Pathways		Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins	Voltage gated Potassium channels Phase 3 - rapid repolarisation
Drugs			Fluvoxamine Erythromycin Dofetilide Enflurane Phenytoin Amsacrine Disopyramide Ibutilide Amitriptyline Terfenadine Loratadine Prazosin Imipramine Fluoxetine Chlorpromazine Sotalol Ciprofloxacin Hydroxyzine Doxazosin Cisapride Astemizole Verapamil Tamoxifen Thioridazine Loperamide Quinidine Ketoconazole Procainamide Promethazine Perhexiline Pimozide Miconazole Amiodarone Carvedilol Doxepin Nefazodone Terazosin Propafenone Flecainide Clarithromycin Halofantrine Bepridil Vanoxerine Dronedarone Azimilide Sertindole Silodosin Vernakalant Tecastemizole Potassium nitrate Pentoxyverine Chlorobutanol Isavuconazole Pitolisant
Diseases		Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT)	Short QT syndrome Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Chronotype ( 30696823) High density lipoprotein cholesterol levels ( 34074324) Ovarian disease with few adhesions ( 28333195) Photic sneeze reflex ( 27182965) Subcutaneous adipose tissue ( 22589738) Takayasu arteritis ( 25604533) White matter hyperintensity burden ( 25663218)	Adult body size ( 32376654) Atrial fibrillation ( 30061737 29892015) Body fat distribution (arm fat ratio) ( 30664634) Body mass index ( 29273807) Chronotype ( 30696823) Diverticular disease ( 30177863) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063 20062061) Electrocardiographic traits (multivariate) ( 32602732) Eyebrow thickness ( 26926045) Metabolic syndrome ( 31589552) QT interval ( 29213071 29874175 24952745 23166209 30679814 19305409 19305408) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) TPE interval (resting) ( 32386560)
Interacting Genes		45 interacting genes: ALAS1 ANXA6 CEP70 CLTCL1 CTNNB1 DDAH2 DES DMPK EEA1 FAF1 FHL2 FSD2 GC GOLGA2 GOLGA6L9 H1-2 HAP1 HSF2BP HSPA4 ITFG1 KASH5 KCNH2 KIAA1549 KIDINS220 MCM3AP MTUS2 MYC PICK1 PITHD1 PTPN11 RABEP1 RNF20 RNF40 TCEA1 TCF4 TFCP2 TOMM20 TRIM23 TSGA10 USP12 USP15 USP25 USP28 VPS37B WWC1	11 interacting genes: ALG10 ALG10B CDC73 FRMD8 KCNE1 KCNE2 NDUFS6 PRKACA RHOH YWHAE YWHAH
Entrez ID		79577	3757
HPRD ID		09581	01069
Ensembl ID		ENSG00000134371	ENSG00000055118
Uniprot IDs		Q6P1J9	A0A090N7W1 A0A090N7X5 A0A090N8Q0 A0AAQ5BGQ9 Q12809 Q15BH2
PDB IDs		5YDE 5YDF 6TED 7OOP 7OPC 7OPD 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH2	1BYW 1UJL 2L0W 2L1M 2L4R 2LE7 2N7G 4HP9 4HQA 5VA1 5VA2 5VA3 6SYG 8IO4 8IO5 8IOB 8ZYN 8ZYO 8ZYP 8ZYQ 9CHP 9CHQ 9CHR 9CHS
Enriched GO Terms of Interacting Partners?		Deubiquitinase Activity Ubiquitin Protein Ligase Binding Beta-catenin-TCF7L2 Complex Neurotrophin Signaling Pathway HULC Complex Cysteine-type Deubiquitinase Activity Identical Protein Binding Protein Deubiquitination Fascia Adherens Protein Modification By Small Protein Removal	Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate Dolichyl Pyrophosphate Glc2Man9GlcNAc2 Alpha-1,2-glucosyltransferase Activity Membrane Repolarization Transmembrane Transporter Binding Regulation Of Membrane Repolarization Regulation Of Metal Ion Transport Regulation Of Heart Rate By Cardiac Conduction Potassium Channel Regulator Activity Regulation Of Monoatomic Ion Transport Cardiac Conduction Regulation Of Membrane Potential Regulation Of Heart Contraction Neural Nucleus Development Negative Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Voltage-gated Potassium Channel Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Blood Circulation Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Potassium Ion Transport Regulation Of Monoatomic Ion Transmembrane Transport Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Negative Regulation Of Monoatomic Ion Transport Potassium Ion Export Across Plasma Membrane Negative Regulation Of Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Intracellular Potassium Ion Homeostasis Dolichol-linked Oligosaccharide Biosynthetic Process Positive Regulation Of Protein Export From Nucleus Regulation Of Multicellular Organismal Process Delayed Rectifier Potassium Channel Activity Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Negative Regulation Of Transporter Activity Negative Regulation Of Potassium Ion Transport Cardiac Muscle Cell Action Potential Involved In Contraction Potassium Ion Homeostasis Regulation Of Protein Export From Nucleus Cardiac Muscle Cell Action Potential Regulation Of System Process Regulation Of Biological Quality Protein Domain Specific Binding Substantia Nigra Development
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