KCNH2 and KCNE2

Number of citations of the paper that reports this interaction (PubMedID 11278781)
0

Data Source:
HPRD (in vivo)

		KCNH2	KCNE2
Description		potassium voltage-gated channel subfamily H member 2	potassium voltage-gated channel subfamily E regulatory subunit 2
Image
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Monoatomic Ion Channel Complex Perinuclear Region Of Cytoplasm Inward Rectifier Potassium Channel Complex	Lysosome Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Apical Plasma Membrane Monoatomic Ion Channel Complex
	Molecular Function	Transcription Cis-regulatory Region Binding Monoatomic Ion Channel Activity Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Scaffold Protein Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Transmembrane Transporter Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Regulation Of Heart Rate By Hormone Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Positive Regulation Of DNA-templated Transcription Potassium Ion Homeostasis Transmembrane Transport Cardiac Muscle Contraction Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To Xenobiotic Stimulus Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Depolarization During Action Potential Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Monoatomic Cation Transmembrane Transport Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Ion Import Across Plasma Membrane	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To Xenobiotic Stimulus Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Delayed Rectifier Potassium Channel Activity Potassium Ion Import Across Plasma Membrane
Pathways		Voltage gated Potassium channels Phase 3 - rapid repolarisation	Phase 3 - rapid repolarisation Phase 2 - plateau phase
Drugs		Fluvoxamine Erythromycin Dofetilide Enflurane Phenytoin Amsacrine Disopyramide Ibutilide Amitriptyline Terfenadine Loratadine Prazosin Imipramine Fluoxetine Chlorpromazine Sotalol Ciprofloxacin Hydroxyzine Doxazosin Cisapride Astemizole Verapamil Tamoxifen Thioridazine Loperamide Quinidine Ketoconazole Procainamide Promethazine Perhexiline Pimozide Miconazole Amiodarone Carvedilol Doxepin Nefazodone Terazosin Propafenone Flecainide Clarithromycin Halofantrine Bepridil Vanoxerine Dronedarone Azimilide Sertindole Silodosin Vernakalant Tecastemizole Potassium nitrate Pentoxyverine Chlorobutanol Isavuconazole Pitolisant	Enflurane Promethazine Miconazole
Diseases		Short QT syndrome Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)	Atrial fibrillation Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Adult body size ( 32376654) Atrial fibrillation ( 30061737 29892015) Body fat distribution (arm fat ratio) ( 30664634) Body mass index ( 29273807) Chronotype ( 30696823) Diverticular disease ( 30177863) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063 20062061) Electrocardiographic traits (multivariate) ( 32602732) Eyebrow thickness ( 26926045) Metabolic syndrome ( 31589552) QT interval ( 29213071 29874175 24952745 23166209 30679814 19305409 19305408) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) TPE interval (resting) ( 32386560)	Body mass index (smoking years interaction) ( 23192594) Cancer ( 29299148) Chronic obstructive pulmonary disease ( 30804561) Coronary artery disease ( 28714974 33020668 32469254 26343387 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Heel bone mineral density ( 28869591 30598549) Height ( 31562340 20881960) Joint mobility (Beighton score) ( 27182965) Lung function (FEV1/FVC) ( 28166213 30804560) Myocardial infarction ( 26343387 26708285) Myocardial infarction (early onset) ( 19198609) Pulmonary function ( 21946350)
Interacting Genes		11 interacting genes: ALG10 ALG10B CDC73 FRMD8 KCNE1 KCNE2 NDUFS6 PRKACA RHOH YWHAE YWHAH	4 interacting genes: HCN2 HCN4 KCNH2 KCNQ1
Entrez ID		3757	9992
HPRD ID		01069	04813
Ensembl ID		ENSG00000055118	ENSG00000159197
Uniprot IDs		A0A090N7W1 A0A090N7X5 A0A090N8Q0 A0AAQ5BGQ9 Q12809 Q15BH2	Q9Y6J6
PDB IDs		1BYW 1UJL 2L0W 2L1M 2L4R 2LE7 2N7G 4HP9 4HQA 5VA1 5VA2 5VA3 6SYG 8IO4 8IO5 8IOB 8ZYN 8ZYO 8ZYP 8ZYQ 9CHP 9CHQ 9CHR 9CHS	2M0Q
Enriched GO Terms of Interacting Partners?		Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate Dolichyl Pyrophosphate Glc2Man9GlcNAc2 Alpha-1,2-glucosyltransferase Activity Membrane Repolarization Transmembrane Transporter Binding Regulation Of Membrane Repolarization Regulation Of Metal Ion Transport Regulation Of Heart Rate By Cardiac Conduction Potassium Channel Regulator Activity Regulation Of Monoatomic Ion Transport Cardiac Conduction Regulation Of Membrane Potential Regulation Of Heart Contraction Neural Nucleus Development Negative Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Voltage-gated Potassium Channel Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Blood Circulation Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Potassium Ion Transport Regulation Of Monoatomic Ion Transmembrane Transport Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Negative Regulation Of Monoatomic Ion Transport Potassium Ion Export Across Plasma Membrane Negative Regulation Of Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Intracellular Potassium Ion Homeostasis Dolichol-linked Oligosaccharide Biosynthetic Process Positive Regulation Of Protein Export From Nucleus Regulation Of Multicellular Organismal Process Delayed Rectifier Potassium Channel Activity Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Negative Regulation Of Transporter Activity Negative Regulation Of Potassium Ion Transport Cardiac Muscle Cell Action Potential Involved In Contraction Potassium Ion Homeostasis Regulation Of Protein Export From Nucleus Cardiac Muscle Cell Action Potential Regulation Of System Process Regulation Of Biological Quality Protein Domain Specific Binding Substantia Nigra Development	Potassium Ion Import Across Plasma Membrane Voltage-gated Potassium Channel Activity Potassium Channel Activity Inorganic Cation Import Across Plasma Membrane Monoatomic Ion Channel Complex Import Across Plasma Membrane Potassium Ion Transmembrane Transport Membrane Depolarization During Action Potential Monoatomic Ion Channel Activity Potassium Ion Transport Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Cardiac Conduction Membrane Depolarization HCN Channel Complex Cellular Response To CAMP Voltage-gated Potassium Channel Complex Regulation Of Membrane Potential Response To CAMP Cellular Response To CGMP Regulation Of Heart Rate Action Potential Intracellularly CAMP-activated Cation Channel Activity Metal Ion Transport Import Into Cell Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Response To CGMP Response To Purine-containing Compound Inorganic Ion Transmembrane Transport Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Potassium Ion Export Across Plasma Membrane Sodium Ion Transport Membrane Depolarization During Cardiac Muscle Cell Action Potential Voltage-gated Sodium Channel Activity Ventricular Cardiac Muscle Cell Action Potential Regulation Of Heart Contraction Muscle Contraction CAMP Binding Monoatomic Ion Transport Membrane Repolarization During Cardiac Muscle Cell Action Potential Delayed Rectifier Potassium Channel Activity Membrane Repolarization During Action Potential Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Sodium Ion Import Across Plasma Membrane
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?