BRCC3 and ICOS

		BRCC3	ICOS
Description		BRCA1/BRCA2-containing complex subunit 3	inducible T cell costimulator
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nuclear Ubiquitin Ligase Complex Spindle Pole Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton BRCA1-A Complex BRISC Complex	Extracellular Region Plasma Membrane Membrane
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Enzyme Regulator Activity Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding K63-linked Deubiquitinase Activity Metal-dependent Deubiquitinase Activity	Protein Binding Signaling Receptor Activity
	Biological Process	DNA Repair Regulation Of DNA Repair Double-strand Break Repair Chromatin Organization Proteolysis DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Response To X-ray Response To Ionizing Radiation Protein Deubiquitination NLRP3 Inflammasome Complex Assembly Mitotic G2/M Transition Checkpoint Positive Regulation Of DNA Repair Cell Division Protein K63-linked Deubiquitination Cellular Response To Ionizing Radiation DNA Repair-dependent Chromatin Remodeling Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of DNA Damage Checkpoint	T Cell Tolerance Induction Immune Response T Cell Costimulation T Follicular Helper Cell Differentiation Cell-cell Adhesion
Pathways		Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Nuclear events stimulated by ALK signaling in cancer
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Venous thromboembolism ( 31676865)	Alopecia areata ( 20596022 25608926) Aluminium levels ( 26025379) Body mass index ( 28892062) Celiac disease ( 20190752) Diastolic blood pressure ( 30224653) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Inflammatory bowel disease ( 26192919) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Ulcerative colitis ( 26192919)
Interacting Genes		14 interacting genes: ANKRD11 BACH1 BRCA1 CD82 FANCG ICOS IFNAR1 ITSN1 NUMA1 SHMT2 SNAPC5 SUMO2 UBC UBE2D1	9 interacting genes: ABI2 ADAM23 BRCC3 ICOSLG NIF3L1 NUFIP2 RC3H1 TNP1 WIF1
Entrez ID		79184	29851
HPRD ID		06465	09196
Ensembl ID		ENSG00000185515	ENSG00000163600
Uniprot IDs		P46736	Q53QY6 Q9Y6W8
PDB IDs		6H3C 6R8F 8PVY 8PY2	6X4G 7JOO
Enriched GO Terms of Interacting Partners?		Nucleoplasm Post-translational Protein Modification Histone H2AK127 Ubiquitin Ligase Activity Damaged DNA Binding Tubulin Binding Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Type I Interferon Receptor Activity Type I Interferon Binding Regulation Of Cellular Respiration Interferon Receptor Activity Cortical Microtubule Anastral Spindle Assembly Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Lateral Cell Cortex Positive Regulation Of Mitotic Spindle Elongation Clathrin-dependent Synaptic Vesicle Endocytosis L-allo-threonine Aldolase Activity Glycine Hydroxymethyltransferase Activity Glycine Biosynthetic Process From Serine Protein Tag Activity Ubiquitin Protein Ligase Binding	T Follicular Helper Cell Differentiation T Cell Differentiation Involved In Immune Response Regulation Of Activated T Cell Proliferation T-helper Cell Differentiation CD4-positive, Alpha-beta T Cell Differentiation Sperm DNA Decondensation Alpha-beta T Cell Differentiation CD4-positive, Alpha-beta T Cell Activation T Cell Activation Involved In Immune Response Zonula Adherens Assembly Cytoplasmic Stress Granule CCR4-NOT Complex Binding Negative Regulation Of Germinal Center Formation Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway
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