ICOS

Description		inducible T cell costimulator
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane
	Molecular Function	Protein Binding Signaling Receptor Activity
	Biological Process	T Cell Tolerance Induction Immune Response T Cell Costimulation T Follicular Helper Cell Differentiation Cell-cell Adhesion
Pathways		Nuclear events stimulated by ALK signaling in cancer
Drugs
Diseases		Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Alopecia areata ( 20596022 25608926) Aluminium levels ( 26025379) Body mass index ( 28892062) Celiac disease ( 20190752) Diastolic blood pressure ( 30224653) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Inflammatory bowel disease ( 26192919) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Ulcerative colitis ( 26192919)
Novel Interacting Genes		9 novel interacting genes: ABI2 ADAM23 BRCC3 ICOSLG NIF3L1 NUFIP2 RC3H1 TNP1 WIF1
Interacting Genes		9 interacting genes: ABI2 ADAM23 BRCC3 ICOSLG NIF3L1 NUFIP2 RC3H1 TNP1 WIF1
Entrez ID		29851
HPRD ID		09196
Ensembl ID		ENSG00000163600
Uniprot IDs		Q53QY6 Q9Y6W8
PDB IDs		6X4G 7JOO
Enriched GO Terms of Interacting Partners?		T Follicular Helper Cell Differentiation T Cell Differentiation Involved In Immune Response Regulation Of Activated T Cell Proliferation T-helper Cell Differentiation CD4-positive, Alpha-beta T Cell Differentiation Sperm DNA Decondensation Alpha-beta T Cell Differentiation CD4-positive, Alpha-beta T Cell Activation T Cell Activation Involved In Immune Response Zonula Adherens Assembly Cytoplasmic Stress Granule CCR4-NOT Complex Binding Negative Regulation Of Germinal Center Formation Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway
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