PPDPF and MT2A

Number of citations of the paper that reports this interaction (PubMedID 34975328)
48

Data Source:
BioGRID (two hybrid)

		PPDPF	MT2A
Description		pancreatic progenitor cell differentiation and proliferation factor	metallothionein 2A
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Nucleus Cytoplasm Cytosol
	Molecular Function		Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Liver Development Cell Differentiation TOR Signaling TORC1 Signaling	Intracellular Copper Ion Homeostasis Intracellular Zinc Ion Homeostasis Detoxification Of Copper Ion Cellular Response To Interleukin-3 Cellular Response To Erythropoietin Negative Regulation Of Growth Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Zinc Ion
Pathways			Metallothioneins bind metals Metallothioneins bind metals Interferon gamma signaling
Drugs			Zinc Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Estimated glomerular filtration rate ( 31152163) Prostate cancer ( 23535732) Serum metabolite levels ( 33031748)
Interacting Genes		11 interacting genes: BABAM2 CTSC DDB1 DNAJB1 GLMN MT2A PLSCR1 PRMT1 RIPK1 RPTOR TRIP6	22 interacting genes: ADAMTS4 ARF6 ASS1 BARD1 DHODH ECT2 EOLA1 HMGB1 JMJD1C LAMTOR5 MCPH1 PAXIP1 PPDPF PRKD1 RCHY1 RIN3 SHBG SPINK7 STOM TNS2 USP25 USP40
Entrez ID		79144	4502
HPRD ID		12750	08863
Ensembl ID		ENSG00000125534	ENSG00000125148
Uniprot IDs		Q9H3Y8	P02795
PDB IDs			1MHU 2MHU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Cell Death Positive Regulation Of Macromolecule Metabolic Process Apoptotic Process Cytoplasm Regulation Of Signal Transduction Programmed Cell Death Regulation Of Immune System Process Regulation Of Protein Metabolic Process Cul4A-RING E3 Ubiquitin Ligase Complex Cellular Response To Stress Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Myeloid Cell Differentiation Regulation Of Primary Metabolic Process Negative Regulation Of Translational Initiation Positive Regulation Of Gene Expression Protein Localization To Lysosome GATOR1 Complex Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of Myeloid Leukocyte Differentiation TORC1 Signaling Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of TORC1 Signaling Regulation Of Cell Cycle Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Phosphate Metabolic Process Regulation Of Viral Genome Replication Protein-containing Complex Binding DNA Damage Response Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition TOR Signaling Cellular Response To Amino Acid Stimulus Lead Ion Binding Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process Hepatocyte Growth Factor Receptor Binding Positive Regulation Of TOR Signaling Chromatin Organization Protein Localization To Vacuole Protein-folding Chaperone Binding Regulation Of Metabolic Process Regulation Of TORC1 Signaling Positive Regulation Of Protein Folding Phosphatidylserine Biosynthetic Process Mercury Ion Binding Phosphatidylserine Exposure On Apoptotic Cell Surface	Negative Regulation Of Endocytosis Positive Regulation Of Mitotic Cytokinetic Process Positive Regulation Of Mitotic Cytokinesis Regulation Of Mitotic Cytokinesis Negative Regulation Of Transport Regulation Of Cellular Component Size Positive Regulation Of Protein Localization To Nucleus Liver Development Regulation Of Establishment Of Protein Localization Regulation Of Cellular Localization Cellular Response To Stress Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Localization Erythrocyte Apoptotic Process Positive Regulation Of Establishment Of Protein Localization Regulation Of Endocytosis Negative Regulation Of Receptor-mediated Endocytosis Argininosuccinate Synthase Activity Argininosuccinate Metabolic Process Regulation Of Intracellular Protein Transport Regulation Of Protein Export From Nucleus Response To Ionizing Radiation Negative Regulation Of MRNA 3'-end Processing Dihydroorotate Dehydrogenase Activity Dihydroorotate Dehydrogenase (quinone) Activity Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Positive Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization To Nucleus Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Regulation Of Skeletal Muscle Contraction By Modulation Of Calcium Ion Sensitivity Of Myofibril Negative Regulation Of Mast Cell Chemotaxis
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