YME1L1 and PSMG1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		YME1L1	PSMG1
Description		YME1 like 1 ATPase	proteasome assembly chaperone 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Nuclear Body	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Protein Folding Chaperone Complex
	Molecular Function	Nucleotide Binding ATP-dependent Peptidase Activity Metalloendopeptidase Activity Protein Binding ATP Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding	Protein Binding Molecular Adaptor Activity Proteasome Binding
	Biological Process	Proteolysis Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Mitochondrion Organization Cell Population Proliferation Cellular Response To Starvation Positive Regulation Of Mitochondrial Fusion Protein Hexamerization Mitochondrial Protein Processing Mitochondrial Protein Catabolic Process Negative Regulation Of Apoptotic Process Neuronal Stem Cell Population Maintenance Regulation Of Stem Cell Division	Cerebellar Granule Cell Precursor Proliferation Proteasome Assembly Chaperone-mediated Protein Complex Assembly Proteasome Core Complex Assembly
Pathways		Processing of SMDT1 Mitochondrial protein degradation Cellular response to mitochondrial stress	Proteasome assembly Proteasome assembly
Drugs
Diseases
GWAS		Shigella-associated diarrhea ( 33649051) Smoking initiation (ever regular vs never regular) ( 30679032)	Alanine aminotransferase levels ( 33547301) Ankylosing spondylitis ( 20062062) C-reactive protein levels ( 21300955) Daytime nap ( 33568662) Daytime sleep phenotypes ( 27126917) Eye morphology ( 29921221) Fibrinogen ( 23969696) Fibrinogen levels ( 26561523 28107422) Finger osteoarthritis severity (hand Klsum) ( 33055079) Glaucoma (primary open-angle) ( 33627673) Height ( 31562340) Inflammatory bowel disease ( 18758464) Pediatric autoimmune diseases ( 26301688) Primary sclerosing cholangitis ( 27992413 23603763) Serum alkaline phosphatase levels ( 33547301) Takayasu arteritis ( 23830517) Triglyceride levels ( 32203549) Ulcerative colitis ( 20228799)
Interacting Genes		7 interacting genes: BCL11A MYOG OGT PSEN1 PSMG1 RNF26 UBC	15 interacting genes: BRCA1 CEBPA CSDE1 GATD3 IDS PRKAR1A PRKAR1B PSMG2 RRP1 SNRNP70 SPRR2A SPTAN1 UBE2A UBE2G2 YME1L1
Entrez ID		10730	8624
HPRD ID		06981	05598
Ensembl ID		ENSG00000136758	ENSG00000183527
Uniprot IDs		Q96TA2	O95456
PDB IDs			8QYJ 8QYL 8QYM 8QYN 8QYS 8QZ9 8TM3 8TM4 8TM5 8TM6 8YIX 8YIY 8YIZ
Enriched GO Terms of Interacting Partners?		Cellular Response To Oxygen-containing Compound Protein Modification Process Regulation Of ATP Metabolic Process Negative Regulation Of Axonogenesis Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Negative Regulation Of Core Promoter Binding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Proteasome Core Complex Assembly Negative Regulation Of Branching Morphogenesis Of A Nerve Negative Regulation Of Neuron Remodeling Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Purine Nucleotide Metabolic Process Chromatin DNA Binding Nucleoplasm Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Positive Regulation Of Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation Of Developmental Process Protein Catabolic Process At Postsynapse Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cajal-Retzius Cell Differentiation Proteolysis Negative Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Neuron Projection Development Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Neurogenesis Negative Regulation Of Protein-containing Complex Assembly Protein O-acetylglucosaminyltransferase Activity Negative Regulation Of Protein Homooligomerization Transcription Regulatory Region Nucleic Acid Binding Negative Regulation Of Neuron Maturation Positive Regulation Of L-glutamate Import Across Plasma Membrane Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Axonogenesis Synaptic Vesicle Targeting Protein Glycosylation Negative Regulation Of Nervous System Development Negative Regulation Of Proteolysis Macromolecule Glycosylation Astrocyte Activation Involved In Immune Response Negative Regulation Of Dendrite Extension Negative Regulation Of Protein Oligomerization Regulation Of Multicellular Organismal Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Sequestering Of Calcium Ion	CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Cellular Response To Tumor Necrosis Factor Protein Kinase A Catalytic Subunit Binding Response To Tumor Necrosis Factor CAMP Binding Negative Regulation Of CAMP/PKA Signal Transduction Postreplication Repair Cellular Response To Cytokine Stimulus Ubiquitin Conjugating Enzyme Activity Regulation Of CAMP/PKA Signal Transduction Multivesicular Body Ciliary Base RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Iduronate-2-sulfatase Activity
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