C1orf50 and CLSPN

		C1orf50	CLSPN
Description		chromosome 1 open reading frame 50	claspin
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component	Nucleus Nucleoplasm Golgi Apparatus
	Molecular Function	Protein Binding Identical Protein Binding	DNA Secondary Structure Binding DNA Binding Protein Binding Anaphase-promoting Complex Binding
	Biological Process	Biological_process	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Peptidyl-serine Phosphorylation Activation Of Protein Kinase Activity Mitotic DNA Replication Checkpoint Signaling
Pathways			Apoptotic cleavage of cellular proteins Activation of ATR in response to replication stress Ub-specific processing proteases Processing of DNA double-strand break ends
Drugs
Diseases
GWAS			Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		18 interacting genes: ADCY4 AHCY APPBP2 CLSPN CRX EIF2B1 EPM2AIP1 EXO5 INCA1 LRP2BP MEOX1 MEOX2 NTAQ1 PPCS REL TCF4 UBC ZMYND12	21 interacting genes: ATR BRCA1 C1orf50 CASP7 CDC45 CDC7 CHEK1 CSNK1G1 CSNK1G2 CSNK1G3 FZR1 POLE RAD17 RAD9A TIMELESS TIPIN TRIM21 USP20 USP28 USP29 USP7
Entrez ID		79078	63967
HPRD ID		14714	09257
Ensembl ID		ENSG00000164008	ENSG00000092853
Uniprot IDs		Q9BV19	Q9HAW4
PDB IDs			7AKO 7PFO 7PLO 8B9D
Enriched GO Terms of Interacting Partners?		Somite Specification DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Segment Specification Somite Development Nucleus DNA-binding Transcription Factor Activity	Negative Regulation Of Cell Cycle Phase Transition DNA Repair DNA Metabolic Process DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Process DNA Damage Response Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Signal Transduction In Response To DNA Damage DNA Replication Checkpoint Signaling Cellular Response To Stress Mitotic DNA Damage Checkpoint Signaling Regulation Of Cell Cycle Process Mitotic DNA Integrity Checkpoint Signaling Regulation Of Cell Cycle Cell Cycle Phase Transition Response To Stress Regulation Of G2/M Transition Of Mitotic Cell Cycle Macromolecule Metabolic Process Negative Regulation Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Regulation Of Cell Cycle G2/M Phase Transition Intracellular Signal Transduction Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Cycle G2/M Phase Transition Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Signal Transduction Regulation Of DNA Replication Cysteine-type Peptidase Activity Nucleus Protein Modification Process Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Cysteine-type Endopeptidase Activity Mitotic Intra-S DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Nucleoplasm Post-translational Protein Modification Deubiquitinase Activity Cysteine-type Deubiquitinase Activity Replication Fork Protection Complex Protein Deubiquitination Protein Serine/threonine Kinase Activity Replication Fork Arrest Mitotic G2 DNA Damage Checkpoint Signaling
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