DCTPP1 and PRR14

		DCTPP1	PRR14
Description		dCTP pyrophosphatase 1	proline rich 14
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Nucleus Nuclear Lamina Nucleoplasm Chromosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Binding Pyrophosphatase Activity Hydrolase Activity Pyrimidine Deoxyribonucleotide Binding Identical Protein Binding Metal Ion Binding Nucleoside Triphosphate Diphosphatase Activity DCTP Diphosphatase Activity	Protein Binding
	Biological Process	DCTP Catabolic Process Nucleoside Triphosphate Catabolic Process DNA Protection DTTP Catabolic Process	Muscle Organ Development
Pathways		Interconversion of nucleotide di- and triphosphates
Drugs
Diseases
GWAS		Urinary sodium excretion ( 31409800)	Immunoglobulin light chain (AL) amyloidosis ( 28025584) Irritable mood ( 29500382) Lymphocyte count ( 32888494) Multiple myeloma ( 33875642) Neurociticism ( 29500382)
Interacting Genes		22 interacting genes: APP ARMC5 FMR1 FXR1 FXR2 GDPD3 LNX1 NIF3L1 NOA1 NTAQ1 PAGR1 PRR14 PSMA1 RUSF1 SDCBP SLX1B SPG21 USP7 VKORC1 ZNF668 ZNF747 ZNF768	6 interacting genes: APP CBX5 CRK DCTPP1 SH3BP4 SH3GL2
Entrez ID		79077	78994
HPRD ID		18310	14541
Ensembl ID		ENSG00000179958	ENSG00000156858
Uniprot IDs		Q9H773	Q9BWN1
PDB IDs		7MU5
Enriched GO Terms of Interacting Partners?		Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Translation Regulator Activity Growth Cone Filopodium Postsynapse RNA Strand Annealing Activity Presynaptic Modulation Of Chemical Synaptic Transmission Intracellular Membraneless Organelle Protein Heterodimerization Activity Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing Regulation Of Synaptic Plasticity Regulation Of Receptor Internalization Cytoplasmic Ribonucleoprotein Granule Presynapse Collateral Sprouting Cytoplasmic Stress Granule DNA Repair Positive Regulation Of Catabolic Process Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Receptor Internalization MRNA Transport MRNA 3'-UTR Binding Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing Dentate Gyrus Development Neuron Maturation Regulation Of Nucleobase-containing Compound Metabolic Process Neuron Projection Frizzled Binding Dendritic Spine RNA Transport Positive Regulation Of Translation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Intracellular Transport Of Viral Material Interleukin-5 Receptor Complex Protein-N-terminal Glutamine Amidohydrolase Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Adrenal Cortex Development Regulation Of Long-term Synaptic Potentiation Chromosome Regulation Of RNA Metabolic Process Regulation Of Translation Molecular Condensate Scaffold Activity	Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Response To Yeast Ephrin Receptor Binding Identical Protein Binding Response To Growth Factor Cellular Response To Growth Factor Stimulus Dendrite Development Regulation Of T Cell Migration Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Lymphocyte Migration Endocytosis Clathrin-coated Pit Response To Fungus Regulation Of Receptor Internalization DTTP Catabolic Process DCTP Diphosphatase Activity DCTP Catabolic Process Neuron Projection Development Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Growth Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of JNK Cascade Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Regulation Of Mononuclear Cell Migration Import Into Cell Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Developmental Cell Growth Microglia Development Developmental Growth Involved In Morphogenesis Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of MAPK Cascade Helper T Cell Diapedesis Regulation Of GTPase Activity Cerebellar Neuron Development Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Negative Regulation Of Blood-brain Barrier Permeability Amino Acid Import
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