SECISBP2 and ELAVL2

		SECISBP2	ELAVL2
Description		SECIS binding protein 2	ELAV like RNA binding protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Ribonucleoprotein Complex	Ribonucleoprotein Complex
	Molecular Function	DNA Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Selenocysteine Insertion Sequence Binding Ribonucleoprotein Complex Binding	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding
	Biological Process	Selenocysteine Incorporation RNA Catabolic Process Translation Striatum Development Forebrain Neuron Development MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Regulation Of DNA-templated Transcription
Pathways		Selenocysteine synthesis
Drugs
Diseases
GWAS		Trunk fat mass ( 28552196)	Anxiety ( 33859377) Asthma ( 34103634 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Attending social / leisure activities ( 34054130) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically inactive individuals ( 28448500) Chronic obstructive pulmonary disease ( 30804561) Feeling guilty ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Fulminant type 1 diabetes ( 30552108) General cognitive ability ( 29844566) Glomerular filtration rate change in heart transplantation ( 30160337) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Intelligence (MTAG) ( 29326435) Lung function (FEV1/FVC) ( 30061609) Neurociticism ( 29500382) Neuroticism ( 27067015 29255261 27089181) Physiological traits ( 31902109) Plasma t-tau levels ( 28100725) Remission after SSRI treatment in MDD or neuroticism ( 29559929) Schizophrenia ( 33169155) Sociability score ( 34054130)
Interacting Genes		10 interacting genes: APP ATXN7L3 DMRTB1 ELAVL2 FAM168A GOLGA2 QKI RNF10 SMAD9 TRNAU1AP	10 interacting genes: CDKN2B ELAVL3 ELAVL4 GLIPR2 HNRNPAB HOXC9 IL11RA NR2E3 RBFOX2 SECISBP2
Entrez ID		79048	1993
HPRD ID		07408	03396
Ensembl ID		ENSG00000187742	ENSG00000107105
Uniprot IDs		A0A1S5UZH3 B4DR97 B4DZC7 Q96T21 Q9H948	A0A0A0MRX1 Q12926
PDB IDs		7ZJW 7ZJX
Enriched GO Terms of Interacting Partners?		Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Nervous System Process Positive Regulation Of Myelination Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Myelination Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of DNA-templated Transcription Amylin Binding Regulation Of RNA Biosynthetic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Internal N(7)-methylguanine-containing RNA Reader Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Translation Regulation Of Protein Import Regulation Of MiRNA Metabolic Process Regulation Of Gene Expression Endosome To Plasma Membrane Transport Vesicle Protein Tetramerization Positive Regulation Of Biosynthetic Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Myofibroblast Contraction Regulation Of Gliogenesis Negative Regulation Of MiRNA Catabolic Process Positive Regulation Of Base-excision Repair DUBm Complex Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of RNA Metabolic Process Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response	Negative Regulation Of MRNA Catabolic Process Regulation Of MRNA Metabolic Process Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Ribonucleoprotein Complex MRNA 3'-UTR Binding Developmental Process MRNA 3'-UTR AU-rich Region Binding Nucleic Acid Binding Cellular Developmental Process MRNA Binding Negative Regulation Of RNA Metabolic Process RNA Metabolic Process MRNA Stabilization Cell Differentiation RNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Stabilization Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Pre-mRNA Intronic Pyrimidine-rich Binding Negative Regulation Of Catabolic Process Nuclear Receptor-mediated Signaling Pathway Cellular Response To Cell-matrix Adhesion MRNA Editing Complex Interleukin-11 Receptor Activity Interleukin-11 Binding Selenocysteine Insertion Sequence Binding Chromosomal 5-methylcytosine DNA Demethylation Pathway Hormone-mediated Signaling Pathway Positive Regulation Of 3'-UTR-mediated MRNA Stabilization Nucleic Acid Metabolic Process Regulation Of Intracellular MRNA Localization Neuronal Ribonucleoprotein Granule Positive Regulation Of Gene Expression Interleukin-11-mediated Signaling Pathway MRNA Metabolic Process Neuron Development Selenocysteine Incorporation Regulation Of MRNA Stability Regulation Of RNA Metabolic Process Regulation Of RNA Stability Megakaryocyte Differentiation Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Intracellular Receptor Signaling Pathway
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