MIS12 and CBX3

Number of citations of the paper that reports this interaction (PubMedID 15502821)
0

Data Source:
HPRD (in vitro, in vivo)

		MIS12	CBX3
Description		MIS12 kinetochore complex component	chromobox 3
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GO Annotations	Cellular Component	MIS12/MIND Type Complex Chromosome, Centromeric Region Kinetochore Spindle Pole Outer Kinetochore Nucleus Chromosome Cytosol	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Euchromatin Heterochromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Pericentric Heterochromatin Spindle Senescence-associated Heterochromatin Focus Chromatin Lock Complex RNA Polymerase II Transcription Regulator Complex Site Of DNA Damage
	Molecular Function	Protein Binding	Transcription Coregulator Binding Chromatin Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Methyltransferase Binding
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly	Chromatin Organization Chromatin Remodeling DNA Damage Response Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Rhythmic Process Cellular Response To Dexamethasone Stimulus
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Promoter Escape Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Abstraction and mental flexibility ( 31596458) Metabolite levels ( 23823483)	Metabolite levels ( 23823483) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		11 interacting genes: AKT1 CBX3 CBX5 DSN1 KLHDC2 KNL1 NDC80 NSL1 PMF1 SUGT1 ZWINT	42 interacting genes: ADAMTSL4 ADNP2 ARL5A ATXN7L2 AURKA AURKB BARD1 CACNB4 CBX1 CBX5 CDC42 DNMT3B DSN1 GDF15 H1-4 H3-4 H3C1 H4C1 HECW2 HIPK2 HTR2C KLF11 L3MBTL1 LAP3 LBR LIG1 MGA MIS12 MKI67 MRPL12 NSD3 PIM1 RAD54L2 SP100 STK16 TAF4 TRIM24 TRIM28 VHL ZNF10 ZNF280D ZNF496
Entrez ID		79003	11335
HPRD ID		12379	05130
Ensembl ID		ENSG00000167842	ENSG00000122565
Uniprot IDs		A8K1M4 Q9H081	A4D177 B8ZZ43 Q13185
PDB IDs		5LSJ 5LSK 8PPR 8Q5H	2L11 3DM1 3KUP 3TZD 5T1I 6HW2 8JZW
Enriched GO Terms of Interacting Partners?		Outer Kinetochore Chromosome, Centromeric Region Kinetochore Attachment Of Spindle Microtubules To Kinetochore Chromosome Segregation MIS12/MIND Type Complex Skeletal Muscle Satellite Cell Proliferation Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Skeletal Muscle Cell Proliferation Nuclear Chromosome Segregation Chromosome Cell Division Knl1/Spc105 Complex Regulation Of Meiosis I Spindle Assembly Checkpoint Homologous Chromosome Orientation In Meiotic Metaphase I Chromosome Organization Nuclear Body Muscle Cell Proliferation Regulation Of Meiosis I Regulation Of Mitotic Sister Chromatid Separation Regulation Of Chromosome Separation Chromosome Localization Nucleus Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Nuclear Division Kinetochore Organization Positive Regulation Of Cell Cycle Checkpoint Nucleoplasm Regulation Of Chromosome Segregation Regulation Of Nuclear Division Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Spindle Pole Regulation Of Cell Cycle Phase Transition Mitotic Spindle Assembly Checkpoint Signaling Pericentric Heterochromatin Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Meiotic Nuclear Division Regulation Of Mitotic Cell Cycle Negative Regulation Of Mitotic Nuclear Division Site Of DNA Damage Regulation Of Chromosome Organization Heterochromatin Positive Regulation Of Cell Cycle Process Regulation Of TRNA Methylation Kinetochore Adaptor Activity Positive Regulation Of Meiosis I Spindle Assembly Checkpoint Regulation Of Meiotic Cell Cycle	Chromatin Remodeling Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of RNA Metabolic Process DNA Binding Heterochromatin Regulation Of Mitotic Cell Cycle Chromo Shadow Domain Binding Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Chromocenter Chromosome Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Nuclear Division Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Heterochromatin Formation Regulation Of Nuclear Division Nuclear Body Regulation Of Cell Cycle Spindle Midzone MIS12/MIND Type Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Kinetochore Chromosome, Centromeric Region Regulation Of Cell Cycle Process Structural Constituent Of Chromatin Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region Protein-containing Complex Chromosome Passenger Complex Attachment Of Spindle Microtubules To Kinetochore Protein-DNA Complex Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleosome Assembly Negative Regulation Of Protein Export From Nucleus Regulation Of Mitotic Cell Cycle Phase Transition Protein Heterodimerization Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process
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