CRELD1 and NUFIP2

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		CRELD1	NUFIP2
Description		CRELD disulfide isomerase 1	nuclear FMR1 interacting protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane Extracellular Matrix Synapse Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol Ribosome Cytoplasmic Stress Granule Membrane Nuclear Body
	Molecular Function	Protein Disulfide Isomerase Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Isomerase Activity	RNA Binding Protein Binding
	Biological Process	Endocardial Cushion Development Cardiac Septum Development
Pathways
Drugs
Diseases		Atrioventricular septal defect; Atrioventricular canal defect
GWAS		Blood protein levels ( 30072576)	Age at first birth ( 34211149) Apolipoprotein B levels ( 32203549) Depression ( 29700475) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fasting glucose ( 34059833) Headache ( 29397368) Heel bone mineral density ( 30598549) White blood cell count ( 32888494)
Interacting Genes		17 interacting genes: ATP5MF COPS6 DRD2 EEF1G EIF6 GDF9 HOXA1 HTR2C KAT5 MAP3K1 MTNR1B NUFIP2 POLA2 PTN SETDB1 SHANK3 ZNF408	145 interacting genes: ADAMTSL4 ADAP2 AGRN ALPP AMOT CHRD COMP COXFA4L2 CRELD1 CRK CYP21A2 CYSRT1 DKK3 EFEMP1 EFEMP2 EGFL7 ESM1 FBLN1 FBLN2 FBLN5 FHL5 FMR1 FUCA2 GABARAP GABARAPL1 GAPDH GRN HNRNPC ICOS KPRP KRT31 KRT37 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1B LCE1D LCE1F LCE2B LCE2C LCE2D LCE3C LCE4A LCE5A LGALS13 LGALS8 LTBP3 LTBP4 LYZL6 MDFI MEGF11 MEGF6 MIR1-1 MIR106B MIR107 MIR128-1 MIR128-2 MIR138-2 MIR15B MIR17 MIR18A MIR19A MIR200C MIR205 MIR20B MIR21 MIR214 MIR25 MIR31 MIR34A MIR34B MIR363 MIR7-1 MIR7-2 MIR7-3 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NBPF19 NELL1 NOTCH2NLA NOTCH3 OGT PCSK5 PEAR1 PEX5 PHF12 PRDX5 RGS17 RGS19 RGS20 SLC22A17 SPRY2 STAB1 STAT3 STMN4 SYNPO TAOK1 TMOD4 TNFRSF4 TRAF1 TRIM42 TRIM55 TRIM63 VWF YPEL3 YWHAG
Entrez ID		78987	57532
HPRD ID		06206	11764
Ensembl ID		ENSG00000163703	ENSG00000108256
Uniprot IDs		A0A669KAV0 A0A669KBB3 A0A804HJJ0 A0A804HKP7 Q96HD1	Q7Z417
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Synapse Structural Plasticity Regulation Of Long-term Synaptic Potentiation Regulation Of Hormone Secretion Auditory Behavior Cognition Regulation Of Circadian Rhythm Neuromuscular Process Negative Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Long-term Synaptic Potentiation Regulation Of System Process Regulation Of Circadian Sleep/wake Cycle, Sleep Memory Regulation Of Behavior Mechanosensory Behavior Regulation Of Circadian Sleep/wake Cycle Regulation Of Nervous System Process Positive Regulation Of Circadian Rhythm Regulation Of Long-term Neuronal Synaptic Plasticity Ionotropic Glutamate Receptor Binding Learning Regulation Of Peptide Hormone Secretion Regulation Of Cell Development Negative Regulation Of Insulin Secretion Regulation Of Neuroblast Proliferation Regulation Of Synaptic Plasticity Positive Regulation Of Cell Development Regulation Of Multicellular Organismal Process Negative Regulation Of Peptide Secretion Semicircular Canal Formation Regulation Of Lipid Biosynthetic Process Assembly Of Large Subunit Precursor Of Preribosome Histone H2AK5 Acetyltransferase Activity Receptor Clustering Regulation Of Neuronal Synaptic Plasticity Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Neurogenesis Regulation Of Hormone Levels Ciliary Membrane Visual Behavior G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Regulation Of Multicellular Organismal Development Positive Regulation Of Cell Differentiation Synapse Negative Regulation Of Sequestering Of Calcium Ion Female Gamete Generation Regulation Of Progesterone Secretion Abducens Nerve Formation Optokinetic Behavior 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Intermediate Filament Keratin Filament Post-transcriptional Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization MiRNA-mediated Gene Silencing By Inhibition Of Translation Extracellular Vesicle MRNA 3'-UTR Binding Negative Regulation Of Gene Expression Negative Regulation Of Translation Positive Regulation Of MRNA Catabolic Process MRNA Destabilization RNA Destabilization Regulation Of Angiogenesis Negative Regulation Of Angiogenesis Regulation Of MRNA Stability Negative Regulation Of Vasculature Development Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Epidermis Development Extracellular Space Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cytokine Production Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Motility Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Metabolic Process Keratinization Regulation Of Translation Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Connective Tissue Replacement Negative Regulation Of Cell Migration Negative Regulation Of Protein Metabolic Process Extracellular Matrix Structural Constituent Negative Regulation Of Interleukin-6-mediated Signaling Pathway
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