NUFIP2 and AMOT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NUFIP2	AMOT
Description		nuclear FMR1 interacting protein 2	angiomotin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Ribosome Cytoplasmic Stress Granule Membrane Nuclear Body	Stress Fiber Ruffle Cytoplasm Cytosol Actin Filament Plasma Membrane Bicellular Tight Junction COP9 Signalosome External Side Of Plasma Membrane Cell Surface Postsynaptic Density Membrane Lamellipodium Endocytic Vesicle Cytoplasmic Vesicle Anchoring Junction Glutamatergic Synapse
	Molecular Function	RNA Binding Protein Binding	Protein Binding Signaling Receptor Activity Angiostatin Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Vasculogenesis In Utero Embryonic Development Gastrulation With Mouth Forming Second Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Chemotaxis Cell-cell Junction Assembly Intracellular Protein Localization Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Regulation Of Cell Migration Hippo Signaling Positive Regulation Of Embryonic Development Cell Migration Involved In Gastrulation Negative Regulation Of Vascular Permeability Blood Vessel Endothelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Size Blood Vessel Morphogenesis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Regulation Of Modification Of Postsynaptic Actin Cytoskeleton
Pathways
Drugs
Diseases
GWAS		Age at first birth ( 34211149) Apolipoprotein B levels ( 32203549) Depression ( 29700475) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fasting glucose ( 34059833) Headache ( 29397368) Heel bone mineral density ( 30598549) White blood cell count ( 32888494)
Interacting Genes		145 interacting genes: ADAMTSL4 ADAP2 AGRN ALPP AMOT CHRD COMP COXFA4L2 CRELD1 CRK CYP21A2 CYSRT1 DKK3 EFEMP1 EFEMP2 EGFL7 ESM1 FBLN1 FBLN2 FBLN5 FHL5 FMR1 FUCA2 GABARAP GABARAPL1 GAPDH GRN HNRNPC ICOS KPRP KRT31 KRT37 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1B LCE1D LCE1F LCE2B LCE2C LCE2D LCE3C LCE4A LCE5A LGALS13 LGALS8 LTBP3 LTBP4 LYZL6 MDFI MEGF11 MEGF6 MIR1-1 MIR106B MIR107 MIR128-1 MIR128-2 MIR138-2 MIR15B MIR17 MIR18A MIR19A MIR200C MIR205 MIR20B MIR21 MIR214 MIR25 MIR31 MIR34A MIR34B MIR363 MIR7-1 MIR7-2 MIR7-3 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NBPF19 NELL1 NOTCH2NLA NOTCH3 OGT PCSK5 PEAR1 PEX5 PHF12 PRDX5 RGS17 RGS19 RGS20 SLC22A17 SPRY2 STAB1 STAT3 STMN4 SYNPO TAOK1 TMOD4 TNFRSF4 TRAF1 TRIM42 TRIM55 TRIM63 VWF YPEL3 YWHAG	58 interacting genes: ACTA1 AMOTL2 AP1M1 APP AQP1 AXIN2 C1orf216 CAPN3 DISC1 FHL2 HOXA1 HPCAL1 KIAA1328 KRT14 KRT15 KRT16 KRT19 KRT24 KRT27 KRT31 KRT34 KRT36 KRT75 LCE1D LMNB2 LMO4 LZTS1 MAGEA4 MAGI1 MAPK3 MED4 MEOX2 MIS18A MYBPC1 MYBPC2 MYOM3 NEDD4 NEDD4L NTAQ1 NUFIP2 PBLD PIK3C2A PIN1 PLG PRKAA2 PTEN PTPA RBM48 SEPTIN1 SLIRP SMC1A SNAPC5 SOCS6 THRA TTN UBC UNC119 YAP1
Entrez ID		57532	154796
HPRD ID		11764	02327
Ensembl ID		ENSG00000108256	ENSG00000126016
Uniprot IDs		Q7Z417	Q4VCS5
PDB IDs			6JJX 7LP2 7LP3 7LP5 7NMA 7NMW 7NMX 7NN2 7NND 7NNE 7NP2 7NPB 7NPG 7OQG 7OQJ 7OQS 7OQU 7OQW
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Intermediate Filament Keratin Filament Post-transcriptional Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization MiRNA-mediated Gene Silencing By Inhibition Of Translation Extracellular Vesicle MRNA 3'-UTR Binding Negative Regulation Of Gene Expression Negative Regulation Of Translation Positive Regulation Of MRNA Catabolic Process MRNA Destabilization RNA Destabilization Regulation Of Angiogenesis Negative Regulation Of Angiogenesis Regulation Of MRNA Stability Negative Regulation Of Vasculature Development Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Epidermis Development Extracellular Space Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cytokine Production Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Motility Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Metabolic Process Keratinization Regulation Of Translation Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Connective Tissue Replacement Negative Regulation Of Cell Migration Negative Regulation Of Protein Metabolic Process Extracellular Matrix Structural Constituent Negative Regulation Of Interleukin-6-mediated Signaling Pathway	Cytoskeleton Organization Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Structural Molecule Activity Supramolecular Fiber Organization Organelle Organization Anatomical Structure Morphogenesis Sarcomere Organization Structural Constituent Of Cytoskeleton Epithelial Cell Differentiation Tissue Morphogenesis Morphogenesis Of An Epithelium Structural Constituent Of Muscle Developmental Process Cytosol M Band Extracellular Exosome Actomyosin Structure Organization Tissue Development Cellular Developmental Process Epidermis Development Protein Binding Actin Cytoskeleton Organization Phosphothreonine Residue Binding Cornified Envelope Cell Differentiation Actin Filament-based Process Response To Calcium Ion Positive Regulation Of Catabolic Process Response To Radiation Response To Metal Ion Skeletal Muscle Thin Filament Assembly Phosphoserine Residue Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Reproductive Behavior Regulation Of Caveolin-mediated Endocytosis Cytoskeleton Cellular Response To Metal Ion Sodium Channel Inhibitor Activity Positive Regulation Of Protein Metabolic Process Striated Muscle Thin Filament Outer Ear Morphogenesis Cellular Response To Salt Stress Potassium Channel Inhibitor Activity Regulation Of Cell Motility Identical Protein Binding
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