DAP3 and TNFRSF10A

Number of citations of the paper that reports this interaction (PubMedID 11376335)
0

Data Source:
HPRD (two hybrid, in vivo)

		DAP3	TNFRSF10A
Description		death associated protein 3	TNF receptor superfamily member 10a
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Mitochondrial Ribosome Mitochondrial Small Ribosomal Subunit Ribosome Small Ribosomal Subunit Ribonucleoprotein Complex	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Surface Membrane Plasma Membrane Raft Membrane Raft
	Molecular Function	Nucleotide Binding RNA Binding Structural Constituent Of Ribosome GTPase Activity Protein Binding GTP Binding Hydrolase Activity	Protease Binding Death Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding TRAIL Binding
	Biological Process	Apoptotic Process Apoptotic Mitochondrial Changes Mitochondrial Translation Apoptotic Signaling Pathway	Apoptotic Process Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Extrinsic Apoptotic Signaling Pathway
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control	Caspase activation via Death Receptors in the presence of ligand Cell surface interactions at the vascular wall Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 TRAIL signaling
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 21909106 23455636) Attention deficit hyperactivity disorder ( 20732625) Central serous retinopathy ( 31872073) Early age-related macular degeneration ( 32843070)
Interacting Genes		15 interacting genes: AHR AR ESR1 ESR2 FADD HIF1A HSP90AA1 NR3C1 PGR PPARA PTEN SLC25A21-AS1 THRA TNFRSF10A TNFRSF25	15 interacting genes: BCL10 BTK CASP8 CD4 COL2A1 DAP3 FADD MADD MOAP1 RASSF1 RIPK1 TNFRSF10B TNFRSF10D TNFSF10 TRADD
Entrez ID		7818	8797
HPRD ID		03646	04679
Ensembl ID		ENSG00000132676	ENSG00000104689
Uniprot IDs		P51398	O00220
PDB IDs		3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5I 7A5K 7L08 7OG4 7P2E 7PNX 7PNY 7PNZ 7PO0 7PO1 7PO2 7PO3 7QI4 7QI5 7QI6 8ANY 8CSP 8CSQ 8CSR 8CSS 8CST 8CSU 8K2A 8OIR 8OIS 8QRK 8QRL 8QRM 8QRN 8RRI 8XT0 8XT2	5CIR
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Estrogen Response Element Binding Nuclear Receptor-mediated Signaling Pathway Transcription Coactivator Binding Intracellular Receptor Signaling Pathway Nuclear Steroid Receptor Activity Hormone-mediated Signaling Pathway Steroid Binding Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Transcription TBP-class Protein Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Lipid Binding Regulation Of MiRNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Apoptotic Process Intracellular Signal Transduction Programmed Cell Death Cell Death Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Animal Organ Development Enzyme Binding Signal Transduction Estrogen Receptor Signaling Pathway DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein-containing Complex Negative Regulation Of MiRNA Transcription Rhythmic Process Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Reproductive Behavior Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nuclear Estrogen Receptor Activity Regulation Of Primary Metabolic Process	Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Death-inducing Signaling Complex Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Signal Transduction Death Receptor Binding Cell Surface Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Apoptotic Process TRAIL Binding Positive Regulation Of Programmed Cell Death Ripoptosome Positive Regulation Of Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Myeloid Leukocyte Differentiation Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Macrophage Differentiation Cellular Response To Mechanical Stimulus Positive Regulation Of Leukocyte Differentiation Negative Regulation Of Necroptotic Process Regulation Of Apoptotic Signaling Pathway Signaling Adaptor Activity Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Programmed Necrotic Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Macrophage Differentiation Positive Regulation Of Defense Response Positive Regulation Of Myeloid Cell Differentiation Death Domain Binding Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Protein Metabolic Process Regulation Of Necroptotic Process Tumor Necrosis Factor Receptor Binding Positive Regulation Of Cytokine Production Regulation Of Signal Transduction Regulation Of Myeloid Leukocyte Differentiation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Death Effector Domain Binding Regulation Of Programmed Necrotic Cell Death
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