TNFRSF10A and TNFSF10

Number of citations of the paper that reports this interaction (PubMedID 10549288)
0

Data Source:
HPRD (in vitro, in vivo)

		TNFRSF10A	TNFSF10
Description		TNF receptor superfamily member 10a	TNF superfamily member 10
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Surface Membrane Plasma Membrane Raft Membrane Raft	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Protease Binding Death Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding TRAIL Binding	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Tumor Necrosis Factor Receptor Superfamily Binding Identical Protein Binding TRAIL Binding Metal Ion Binding
	Biological Process	Apoptotic Process Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Extrinsic Apoptotic Signaling Pathway	Apoptotic Process Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Signaling TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Caspase activation via Death Receptors in the presence of ligand Cell surface interactions at the vascular wall Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 TRAIL signaling	Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited Dimerization of procaspase-8 TRAIL signaling
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 21909106 23455636) Attention deficit hyperactivity disorder ( 20732625) Central serous retinopathy ( 31872073) Early age-related macular degeneration ( 32843070)	Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Breast cancer ( 28171663) Breast cancer (estrogen-receptor negative) ( 28171663) Carotid plaque burden ( 28282560) Cocaine dependence ( 31212010) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Liver volume ( 34128465) Monocyte percentage of white cells ( 27863252) TRAIL levels ( 27989323) Triglyceride levels ( 32203549) Triglycerides ( 30275531)
Interacting Genes		15 interacting genes: BCL10 BTK CASP8 CD4 COL2A1 DAP3 FADD MADD MOAP1 RASSF1 RIPK1 TNFRSF10B TNFRSF10D TNFSF10 TRADD	10 interacting genes: ACP5 CASP3 CFTR RBM48 TNFRSF10A TNFRSF10B TNFRSF10C TNFRSF10D TNFRSF11B ZDHHC17
Entrez ID		8797	8743
HPRD ID		04679	04670
Ensembl ID		ENSG00000104689	ENSG00000121858
Uniprot IDs		O00220	P50591 Q6IBA9
PDB IDs		5CIR	1D0G 1D2Q 1D4V 1DG6 1DU3 4N90 5CIR
Enriched GO Terms of Interacting Partners?		Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Death-inducing Signaling Complex Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Signal Transduction Death Receptor Binding Cell Surface Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Apoptotic Process TRAIL Binding Positive Regulation Of Programmed Cell Death Ripoptosome Positive Regulation Of Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Myeloid Leukocyte Differentiation Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Macrophage Differentiation Cellular Response To Mechanical Stimulus Positive Regulation Of Leukocyte Differentiation Negative Regulation Of Necroptotic Process Regulation Of Apoptotic Signaling Pathway Signaling Adaptor Activity Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Programmed Necrotic Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Macrophage Differentiation Positive Regulation Of Defense Response Positive Regulation Of Myeloid Cell Differentiation Death Domain Binding Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Protein Metabolic Process Regulation Of Necroptotic Process Tumor Necrosis Factor Receptor Binding Positive Regulation Of Cytokine Production Regulation Of Signal Transduction Regulation Of Myeloid Leukocyte Differentiation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Death Effector Domain Binding Regulation Of Programmed Necrotic Cell Death	TRAIL Binding TRAIL-activated Apoptotic Signaling Pathway Death Receptor Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cell Death Apoptotic Process Programmed Cell Death Activation Of NF-kappaB-inducing Kinase Activity Cell Surface Apoptotic Signaling Pathway Golgi-associated Vesicle Membrane Extrinsic Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Activation Of Protein Kinase Activity Signaling Receptor Activity Negative Regulation Of Superoxide Anion Generation Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding TRAIL Receptor Activity Perforant Pathway To Dendrate Granule Cell Synapse Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Phospholipase A2 Activator Activity Positive Regulation Of Anion Channel Activity Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Protease Binding Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Monoatomic Anion Transport Multicellular Organismal-level Homeostasis Anterior Neural Tube Closure Cellular Response To Staurosporine Positive Regulation Of Enamel Mineralization Positive Regulation Of Protein Kinase Activity Luteolysis Glial Cell Apoptotic Process Transepithelial Water Transport Positive Regulation Of Kinase Activity Protein-cysteine S-myristoyltransferase Activity Negative Regulation Of Immune System Process Acid Phosphatase Activity Response To Anesthetic Positive Regulation Of Tooth Mineralization Protein-cysteine S-stearoyltransferase Activity Ferric Iron Binding Death-inducing Signaling Complex
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?