ZNF33A and MAP3K20

Number of citations of the paper that reports this interaction (PubMedID 12535642)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		ZNF33A	MAP3K20
Description		zinc finger protein 33A	mitogen-activated protein kinase kinase kinase 20
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm Cytosol
	Molecular Function	DNA Binding DNA-binding Transcription Factor Activity Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity RRNA Binding Protein Kinase Regulator Activity Protein Kinase Activator Activity Ribosome Binding Metal Ion Binding Small Ribosomal Subunit RRNA Binding Protein Serine Kinase Activity Stalled Ribosome Sensor Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	DNA Damage Checkpoint Signaling MAPK Cascade Translational Initiation Protein Phosphorylation Inflammatory Response Cytoskeleton Organization Chromosome Segregation JNK Cascade Cell Death Regulation Of Mitotic Metaphase/anaphase Transition Cell Differentiation Stress-activated Protein Kinase Signaling Cascade Intracellular Signal Transduction P38MAPK Cascade Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Autophosphorylation Stress-activated MAPK Cascade Protein Maturation Limb Development Pyroptotic Inflammatory Response Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Cellular Response To Gamma Radiation Cellular Response To UV-B GCN2-mediated Signaling Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Mitotic DNA Damage Checkpoint NLRP1 Inflammasome Complex Assembly
Pathways		Generic Transcription Pathway Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins
Drugs			Dasatinib Fostamatinib
Diseases
GWAS			Haemorrhoidal disease ( 33888516)
Interacting Genes		2 interacting genes: ITGB1 MAP3K20	29 interacting genes: CCDC69 CRMP1 DDAH2 EZH2 IGHM ITSN1 MAP2K4 MAP2K6 MAP2K7 MIDN MPP1 NEDD4L RBX1 RNF19A RPS6KA5 SMARCB1 SRPK2 TGFBR1 UNC119 VPS33B YWHAG YWHAZ ZFP2 ZNF33A ZNF567 ZNF593 ZNF660 ZNF746 ZNF775
Entrez ID		7581	51776
HPRD ID		11710	11791
Ensembl ID		ENSG00000189180	ENSG00000091436
Uniprot IDs		A0A0A0MR11 A0A0A0MRS1 Q06730	D4Q8H0 Q9NYL2
PDB IDs			5HES 5X5O 6JUT 6JUU 7YAW 7YAZ
Enriched GO Terms of Interacting Partners?		Myoblast Fate Specification Magnesium Ion Binding Integrin Alpha6-beta1 Complex Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Integrin Alpha1-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alpha7-beta1 Complex Integrin Alphav-beta1 Complex Integrin Alpha11-beta1 Complex Cardiac Cell Fate Specification Integrin Alpha3-beta1 Complex Integrin Alpha9-beta1 Complex Positive Regulation Of Mitotic DNA Damage Checkpoint Positive Regulation Of L-glutamate Import Across Plasma Membrane Response To Light Stimulus Integrin Alpha4-beta1 Complex Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Calcium-independent Cell-matrix Adhesion Regulation Of Collagen Catabolic Process Integrin Alpha2-beta1 Complex Formation Of Radial Glial Scaffolds GCN2-mediated Signaling Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Stalled Ribosome Sensor Activity C-X3-C Chemokine Binding Integrin Binding Involved In Cell-matrix Adhesion Myelin Sheath Abaxonal Region Collagen Binding Involved In Cell-matrix Adhesion Positive Regulation Of DNA Damage Checkpoint Regulation Of Spontaneous Synaptic Transmission Reactive Gliosis Positive Regulation Of Neurotransmitter Uptake Response To Radiation Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Cerebellar Climbing Fiber To Purkinje Cell Synapse Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Apoptotic Process Regulation Of L-glutamate Import Across Plasma Membrane Positive Regulation Of Programmed Cell Death Inflammatory Response Germ Cell Migration JUN Kinase Kinase Kinase Activity Negative Regulation Of Translation In Response To Stress Small Ribosomal Subunit RRNA Binding NLRP1 Inflammasome Complex Assembly Regulation Of Synapse Pruning CD40 Signaling Pathway Regulation Of Translation In Response To Endoplasmic Reticulum Stress	Regulation Of Caveolin-mediated Endocytosis MAP Kinase Kinase Activity JUN Kinase Kinase Activity TORC1 Signaling Regulation Of Metabolic Process TOR Signaling Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of Primary Metabolic Process MAPK Cascade Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Regulation Of Synapse Organization Regulation Of RNA Metabolic Process Nucleus Protein Kinase Activity Cellular Senescence Protein Modification Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of TORC1 Signaling Molecular Adaptor Activity Protein Serine Kinase Activity Regulation Of Motor Neuron Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transferase Activity Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Kinase Activity Intracellular Signal Transduction Negative Regulation Of TOR Signaling Regulation Of Macromolecule Biosynthetic Process Regulation Of TORC1 Signaling Stress-activated MAPK Cascade Fc-epsilon Receptor Signaling Pathway Stress-activated Protein Kinase Signaling Cascade P38MAPK Cascade Regulation Of Kinase Activity Spindle Midzone Blastocyst Development Hepatocyte Homeostasis Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Histone H2AS1 Kinase Activity Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Regulation Of Postsynapse Organization Protein Metabolic Process
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