MAP3K20 and VPS33B

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MAP3K20	VPS33B
Description		mitogen-activated protein kinase kinase kinase 20	VPS33B late endosome and lysosome associated
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Clathrin-coated Vesicle HOPS Complex Platelet Alpha Granule Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane CORVET Complex Perinuclear Region Of Cytoplasm Recycling Endosome Vesicle Tethering Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity RRNA Binding Protein Kinase Regulator Activity Protein Kinase Activator Activity Ribosome Binding Metal Ion Binding Small Ribosomal Subunit RRNA Binding Protein Serine Kinase Activity Stalled Ribosome Sensor Activity	Protein Binding Protein-containing Complex Binding
	Biological Process	DNA Damage Checkpoint Signaling MAPK Cascade Translational Initiation Protein Phosphorylation Inflammatory Response Cytoskeleton Organization Chromosome Segregation JNK Cascade Cell Death Regulation Of Mitotic Metaphase/anaphase Transition Cell Differentiation Stress-activated Protein Kinase Signaling Cascade Intracellular Signal Transduction P38MAPK Cascade Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Autophosphorylation Stress-activated MAPK Cascade Protein Maturation Limb Development Pyroptotic Inflammatory Response Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Cellular Response To Gamma Radiation Cellular Response To UV-B GCN2-mediated Signaling Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Mitotic DNA Damage Checkpoint NLRP1 Inflammasome Complex Assembly	Intracellular Protein Transport Endosome Organization Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Peptidyl-lysine Hydroxylation Collagen Fibril Organization Melanosome Localization Lysosome Localization Collagen Metabolic Process Megakaryocyte Development Skin Morphogenesis Membrane Fusion Platelet Alpha Granule Organization Regulation Of Platelet Aggregation Phagosome-lysosome Fusion Autophagosome Maturation
Pathways			Prevention of phagosomal-lysosomal fusion SARS-CoV-2 modulates autophagy
Drugs		Dasatinib Fostamatinib
Diseases			Arthrogryposis, renal dysfunction, and cholestasis; ARC syndrome
GWAS		Haemorrhoidal disease ( 33888516)	Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Feeling hurt ( 29500382) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566) Red cell distribution width ( 32888494)
Interacting Genes		29 interacting genes: CCDC69 CRMP1 DDAH2 EZH2 IGHM ITSN1 MAP2K4 MAP2K6 MAP2K7 MIDN MPP1 NEDD4L RBX1 RNF19A RPS6KA5 SMARCB1 SRPK2 TGFBR1 UNC119 VPS33B YWHAG YWHAZ ZFP2 ZNF33A ZNF567 ZNF593 ZNF660 ZNF746 ZNF775	6 interacting genes: APP MAP3K20 MAPK8IP2 TNIP1 UVRAG VIPAS39
Entrez ID		51776	26276
HPRD ID		11791	10541
Ensembl ID		ENSG00000091436	ENSG00000184056
Uniprot IDs		D4Q8H0 Q9NYL2	A0A0S2Z577 B7Z1N4 F5H008 Q9H267
PDB IDs		5HES 5X5O 6JUT 6JUU 7YAW 7YAZ
Enriched GO Terms of Interacting Partners?		Regulation Of Caveolin-mediated Endocytosis MAP Kinase Kinase Activity JUN Kinase Kinase Activity TORC1 Signaling Regulation Of Metabolic Process TOR Signaling Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of Primary Metabolic Process MAPK Cascade Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Regulation Of Synapse Organization Regulation Of RNA Metabolic Process Nucleus Protein Kinase Activity Cellular Senescence Protein Modification Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of TORC1 Signaling Molecular Adaptor Activity Protein Serine Kinase Activity Regulation Of Motor Neuron Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transferase Activity Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Kinase Activity Intracellular Signal Transduction Negative Regulation Of TOR Signaling Regulation Of Macromolecule Biosynthetic Process Regulation Of TORC1 Signaling Stress-activated MAPK Cascade Fc-epsilon Receptor Signaling Pathway Stress-activated Protein Kinase Signaling Cascade P38MAPK Cascade Regulation Of Kinase Activity Spindle Midzone Blastocyst Development Hepatocyte Homeostasis Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Histone H2AS1 Kinase Activity Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Regulation Of Postsynapse Organization Protein Metabolic Process	Protein-containing Complex Organization Mating Behavior Early Endosome Modulation Of Excitatory Postsynaptic Potential Reproductive Behavior Autophagosome Maturation Regulation Of Stress-activated Protein Kinase Signaling Cascade Protein Kinase Activator Activity JNK Cascade Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Lytic Vacuole Positive Regulation Of Mitotic DNA Damage Checkpoint Protein-containing Complex Assembly Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Recycling Endosome Response To Stress Endosome To Plasma Membrane Transport Vesicle Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Positive Regulation Of Endothelin Production Growth Cone Filopodium Defense Response Lipoprotein Particle Regulation Of Cellular Response To Stress Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of Nervous System Process Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Cell Communication Regulation Of MAPK Cascade Chromosome Segregation Protein-containing Complex Disassembly Maintenance Of Golgi Location Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of JNK Cascade Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Learning Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling
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