ZBTB14 and PLAGL1

		ZBTB14	PLAGL1
Description		zinc finger and BTB domain containing 14	PLAG1 like zinc finger 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Aggresome	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Nuclear Body
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Kidney Development Regulation Of Immune System Process Heart Valve Development Cardiac Septum Development Negative Regulation Of DNA-templated Transcription Coronary Vasculature Development	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle
Pathways			TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases			Transient neonatal diabetes mellitus (TNDM)
GWAS		Cerebral amyloid deposition (PET imaging) ( 26252872) Lacunar stroke ( 33773637)	Anti-saccade response ( 29064472) Eosinophil percentage of granulocytes ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density x serum urate levels interaction ( 34046847) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Peanut allergy (maternal genetic effects) ( 29489655) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		61 interacting genes: AP1M1 AP4B1 ASXL3 ATP5PO ATRIP B4GALT6 BAZ2B BYSL C2orf68 CAPN6 CBX8 CDK16 CDKL3 CEP19 COLEC12 DDX6 EAF1 EIF1AD ENKD1 EPM2AIP1 FAM161A FAM90A1 GORASP2 INTS3 ITGB7 KAT5 KCNAB3 MAD2L1BP MFAP1 MORF4L2 MRPL11 NAA10 NAA11 OGT PIN1 PLAGL1 PNKP POLR2L PRMT1 PTPN2 RNASEH2B RNPS1 RPA1 RPA2 RPL9 RPS25 RPS7 SCNM1 SDCBP SLC4A1 SNRPB2 SYT16 TCEANC TM9SF1 TRIM55 TSTD2 TXN2 WNT9A ZBTB21 ZCCHC10 ZMAT2	13 interacting genes: CREBBP DAXX DRC3 EP300 KAT2B PIAS2 PML SMAD3 SUMO1 TLE5 TP53 UBE2I ZBTB14
Entrez ID		7541	5325
HPRD ID		03674	16010
Ensembl ID		ENSG00000198081	ENSG00000118495
Uniprot IDs		B2R850 O43829	A1YLA1 A1YLA2 Q9UM63
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Macromolecule Metabolic Process Nucleic Acid Metabolic Process Regulation Of Double-strand Break Repair Regulation Of DNA Repair Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Site Of Double-strand Break Protein N-terminal-serine Acetyltransferase Activity Nucleotide-excision Repair Protein Binding DNA Repair Regulation Of Cell Cycle Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress Recombinational Repair Positive Regulation Of DNA Repair Double-strand Break Repair Double-strand Break Repair Via Homologous Recombination Mismatch Repair NatA Complex Protein-N-terminal Amino-acid Acetyltransferase Activity Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Acetylation Positive Regulation Of Double-strand Break Repair Positive Regulation Of Mitotic Sister Chromatid Segregation Positive Regulation Of Double-strand Break Repair Via Homologous Recombination G-rich Strand Telomeric DNA Binding RNA Processing MRNA Splicing, Via Spliceosome U2-type Precatalytic Spliceosome N-terminal Protein Amino Acid Acetylation Clathrin Adaptor Complex Organelle Assembly RNA Splicing, Via Transesterification Reactions DNA Replication Factor A Complex Cytoplasmic Translation RNA Metabolic Process DNA Metabolic Process Regulation Of Cell Cycle Process	Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process PML Body Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Stabilization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Binding Transcription Coactivator Binding Protein Sumoylation N-terminal Protein Amino Acid Acetylation Peptidyl-lysine Acetylation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Stability P53 Binding Acetyltransferase Activity SUMO Transferase Activity Histone H3K27 Acetyltransferase Activity Regulation Of Transcription By RNA Polymerase II Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Rhythmic Process Intracellular Signaling Cassette Histone H3K18 Acetyltransferase Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Regulation Of Gene Expression Response To Hypoxia Protein Acetylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Transcription Coregulator Activity Regulation Of Macromolecule Biosynthetic Process Response To Decreased Oxygen Levels Apoptotic Signaling Pathway Regulation Of Primary Metabolic Process Response To Oxygen Levels Chromatin Remodeling Cellular Response To Stress
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