YY1 and FOXP2

Number of citations of the paper that reports this interaction (PubMedID 29365100)
0

Data Source:
BioGRID (fluorescent resonance energy transfer)

		YY1	FOXP2
Description		YY1 transcription factor	forkhead box P2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromatin Silencing Complex Nuclear Matrix Ino80 Complex PcG Protein Complex	Chromatin Nucleus
	Molecular Function	Four-way Junction DNA Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding SMAD Binding Metal Ion Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II RNA Localization DNA Damage Response Spermatogenesis Anterior/posterior Pattern Specification Response To UV-C Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Hemopoiesis Cell Differentiation B Cell Differentiation Negative Regulation Of Interferon-beta Production Regulation Of Chromosome Organization Cellular Response To UV Response To Prostaglandin F Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Camera-type Eye Morphogenesis Chromosome Organization Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Interleukin-1 Immunoglobulin Heavy Chain V-D-J Recombination Negative Regulation Of MiRNA Transcription Positive Regulation Of Telomere Maintenance In Response To DNA Damage	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Post-embryonic Development Gene Expression Cerebellum Development Cerebellar Purkinje Cell Differentiation Caudate Nucleus Development Putamen Development Cerebral Cortex Development Lung Development Vocal Learning Camera-type Eye Development Negative Regulation Of DNA-templated Transcription Lung Alveolus Development Animal Organ Development Smooth Muscle Tissue Development Positive Regulation Of Epithelial Cell Proliferation Righting Reflex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Epithelial Cell Proliferation Involved In Lung Morphogenesis Vocalization Behavior
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis UCH proteinases DNA Damage Recognition in GG-NER TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Estrogen-dependent gene expression	Positive Regulation of CDH1 Gene Transcription
Drugs
Diseases			Speech-language disorder 1 (SPCH1)
GWAS		Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Pulse pressure ( 30224653)	Adult body size ( 32376654) Adventurousness ( 30643258) Age at first birth ( 34211149 27798627) Age at first sexual intercourse ( 34211149) Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder ( 30478444) Attention deficit hyperactivity disorder or cannabis use ( 30610198) Beard thickness ( 26926045) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 28892062 25673413) Brain morphology (MOSTest) ( 32665545) Cannabis use disorder ( 33096046) Childhood maltreatment ( 32066696) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Congenital heart disease (maternal effect) ( 28468790) Conotruncal heart defects (maternal effects) ( 28468790) Crohn's disease ( 22936669) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Drug experimentation measurement ( 30718321) Feeling tense ( 29500382) Fish- and plant-related diet ( 32066663) Frailty index ( 34431594) Gastroesophageal reflux disease ( 31527586) General risk tolerance (MTAG) ( 30643258) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Household income (MTAG) ( 31844048) Insomnia ( 32332799) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Irritable mood ( 29500382) Major depressive disorder (MTAG) ( 33479212) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Multisite chronic pain ( 33830993 31194737) Neuroticism ( 29255261) Number of sexual partners ( 30643258) Pelvic organ prolapse (moderate/severe) ( 26545240) Schizophrenia, bipolar disorder or recurrent major depressive disorder ( 34099189) Self-reported risk-taking behaviour ( 30181555 30271922) Serum sulfate level ( 27412988) Sleep duration ( 27992416) Sleep duration (short sleep) ( 30846698) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Subcortical volume (MOSTest) ( 32665545) Urate levels in obese individuals ( 25811787) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) Weight ( 28552196)
Interacting Genes		99 interacting genes: ALOXE3 APP ATF2 ATF6 ATF7 AURKA BAP1 BRCA1 CDKN2A CEBPA CEP76 CREB1 CREBBP CRKL CYSRT1 DNMT3L E2F2 E2F3 EED EP300 ESM1 FHL2 FKBP1A FKBP3 FOXP1 FOXP2 FOXP4 GFER GMCL1 GRN GTF2I HDAC2 HDAC3 HMGB1 HNF1B HOXA11 IL10 ITCH KAT2B KRTAP1-3 KRTAP1-5 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP4-2 KRTAP4-5 KRTAP5-6 KRTAP9-3 KRTAP9-8 MDFI MED20 MTA2 MYC NEDD4L NFIC NFIX NFKB1 NOTCH1 NPM1 NR1H2 PIAS4 PLEKHF2 PPIA PRKD1 PSMD9 RAF1 RYBP SAP30 SF3A2 SKP2 SLC39A7 SMAD1 SMAD2 SMAD3 SMURF2 SP1 SPRY1 SREBF1 TESK1 TFCP2 TP53 TRIM42 TWIST1 UBE2I UHRF2 USP21 USP7 VWC2 XAGE1A XAGE1B YAF2 ZNF232 ZNF85 ZRANB2	28 interacting genes: ARSB CAV1 CAV2 CCNC CDK3 FAM124A FOXP1 FOXP4 GPR85 ING3 LNX1 MAPK3 MAST3 NR2F1 NR2F2 PIAS3 PIN1 RPIA SATB1 SATB2 SDCBP SOX5 SP4 TBR1 TLE5 TSACC YY1 ZMYM2
Entrez ID		7528	93986
HPRD ID		02482	05611
Ensembl ID		ENSG00000100811	ENSG00000128573
Uniprot IDs		P25490	B7ZLK5 O15409 Q8N6B5 Q8N6B6 X5D2H2
PDB IDs		1UBD 1ZNM 4C5I	2A07 2AS5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Intermediate Filament Chromatin Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Keratin Filament Epigenetic Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription DNA Binding Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription By RNA Polymerase II Negative Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Identical Protein Binding Regulation Of MiRNA Metabolic Process Regulation Of Programmed Cell Death Transcription Regulator Complex Chromatin Remodeling	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Caveolar Macromolecular Signaling Complex DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process G0 To G1 Transition Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Caveolin-mediated Endocytosis Chromatin Regulation Of Metabolic Process Caveola Assembly Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Transcription By RNA Polymerase II Plasma Membrane Raft Assembly Receptor-mediated Endocytosis Of Virus By Host Cell Membrane Raft Assembly Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Nucleus Regulation Of Locomotion Plasma Membrane Raft Organization Endocytosis Involved In Viral Entry Into Host Cell Caveola DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Zinc Ion Binding Cartilage Development Acrosomal Membrane Negative Regulation Of Cardiac Muscle Tissue Growth Regulation Of Anoikis
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