XPNPEP1 and HBG2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		XPNPEP1	HBG2
Description		X-prolyl aminopeptidase 1	hemoglobin subunit gamma 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Cytosol Hemoglobin Complex Haptoglobin-hemoglobin Complex Blood Microparticle
	Molecular Function	Aminopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Manganese Ion Binding Protein Homodimerization Activity Metal Ion Binding Metalloaminopeptidase Activity	Oxygen Carrier Activity Protein Binding Oxygen Binding Heme Binding Hemoglobin Alpha Binding Metal Ion Binding
	Biological Process	Proteolysis Bradykinin Catabolic Process Negative Regulation Of Programmed Cell Death CARD8 Inflammasome Complex Assembly	Carbon Dioxide Transport Oxygen Transport Erythrocyte Development
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Biliary atresia ( 20460270) Bipolar disorder ( 28072414 31043756) Refractive error ( 32231278)	Beta thalassemia/hemoglobin E disease ( 20183929) Hemoglobin ( 28548082) Hemoglobin levels ( 26366553) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Logical memory (delayed recall) in normal cognition ( 29274321) Logical memory (immediate recall) in normal cognition ( 29274321) Malaria ( 31844061) Malate levels ( 31560688) Mean corpuscular hemoglobin concentration ( 28453575 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		13 interacting genes: ANK3 DISC1 GORASP2 GSK3B HBG2 MAPK9 NUDT3 POLA2 RHOH RINT1 SUMO2 UBC UBE2D3	11 interacting genes: APP CYB5R3 HBA1 HBA2 HBB HBM HBQ1 HBZ RPSA SMAD5 XPNPEP1
Entrez ID		7511	3048
HPRD ID		03899	00792
Ensembl ID		ENSG00000108039	ENSG00000196565
Uniprot IDs		Q5T6H7 Q9NQW7	D9YZU9 P69892
PDB IDs		3CTZ	1FDH 4MQJ 4MQK 7QU4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Tag Activity Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Cell Adhesion Presynapse Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Microtubule Anchoring At Centrosome Glutamatergic Synapse Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Diphosphoinositol Polyphosphate Catabolic Process Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Maintenance Of Protein Location In Plasma Membrane Cytosol Positive Regulation Of Cell-matrix Adhesion Superior Temporal Gyrus Development Ubiquitin Protein Ligase Binding Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Glycogen (starch) Synthase Activity Protein Localization To Tricellular Tight Junction 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Inositol Phosphate Catabolic Process Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Positive Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Establishment Of Protein Localization TOR Signaling Regulation Of Axon Extension JUN Kinase Activity Diphosphoinositol Polyphosphate Metabolic Process Bis(5'-adenosyl)-hexaphosphatase Activity Diadenosine Hexaphosphate Catabolic Process Diadenosine Pentaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process Diphosphoinositol-polyphosphate Diphosphatase Activity Endopolyphosphatase Activity Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone	Hemoglobin Complex Haptoglobin-hemoglobin Complex Oxygen Carrier Activity Oxygen Transport Myeloid Cell Development Oxygen Binding Erythrocyte Development Hemopoiesis Heme Binding Carbon Dioxide Transport Haptoglobin Binding One-carbon Compound Transport Nitric Oxide Transport Cell Development Endocytic Vesicle Lumen Hydrogen Peroxide Catabolic Process Iron Ion Binding Peroxidase Activity Hydrogen Peroxide Metabolic Process G Protein-coupled Receptor Binding Cellular Oxidant Detoxification Metal Ion Binding Reactive Oxygen Species Metabolic Process Response To Hydrogen Peroxide Cellular Detoxification Blood Microparticle Cellular Developmental Process Extracellular Exosome Response To Reactive Oxygen Species Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Defense Response Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Negative Regulation Of Fas Signaling Pathway Response To Oxidative Stress PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium
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