XPNPEP1

Description		X-prolyl aminopeptidase 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Aminopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Manganese Ion Binding Protein Homodimerization Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Proteolysis Bradykinin Catabolic Process Negative Regulation Of Programmed Cell Death CARD8 Inflammasome Complex Assembly
Pathways
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Biliary atresia ( 20460270) Bipolar disorder ( 28072414 31043756) Refractive error ( 32231278)
Novel Interacting Genes		13 novel interacting genes: ANK3 DISC1 GORASP2 GSK3B HBG2 MAPK9 NUDT3 POLA2 RHOH RINT1 SUMO2 UBC UBE2D3
Interacting Genes		13 interacting genes: ANK3 DISC1 GORASP2 GSK3B HBG2 MAPK9 NUDT3 POLA2 RHOH RINT1 SUMO2 UBC UBE2D3
Entrez ID		7511
HPRD ID		03899
Ensembl ID		ENSG00000108039
Uniprot IDs		Q5T6H7 Q9NQW7
PDB IDs		3CTZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Tag Activity Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Cell Adhesion Presynapse Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Microtubule Anchoring At Centrosome Glutamatergic Synapse Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Diphosphoinositol Polyphosphate Catabolic Process Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Maintenance Of Protein Location In Plasma Membrane Cytosol Positive Regulation Of Cell-matrix Adhesion Superior Temporal Gyrus Development Ubiquitin Protein Ligase Binding Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Glycogen (starch) Synthase Activity Protein Localization To Tricellular Tight Junction 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Inositol Phosphate Catabolic Process Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Positive Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Establishment Of Protein Localization TOR Signaling Regulation Of Axon Extension JUN Kinase Activity Diphosphoinositol Polyphosphate Metabolic Process Bis(5'-adenosyl)-hexaphosphatase Activity Diadenosine Hexaphosphate Catabolic Process Diadenosine Pentaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process Diphosphoinositol-polyphosphate Diphosphatase Activity Endopolyphosphatase Activity Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone
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