XPC and LSM3

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		XPC	LSM3
Description		XPC complex subunit, DNA damage recognition and repair factor	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
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GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 2 Complex Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane XPC Complex Site Of DNA Damage	P-body Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex Ribonucleoprotein Complex
	Molecular Function	Heteroduplex DNA Loop Binding Bubble DNA Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity Protein Binding Protein-containing Complex Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA Damage Sensor Activity	RNA Binding Protein Binding U6 SnRNA 3'-end Binding
	Biological Process	Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Repair Nucleotide-excision Repair Mismatch Repair DNA Damage Response Regulation Of Mitotic Cell Cycle Response To Xenobiotic Stimulus Response To UV-B Response To Auditory Stimulus Mitotic Intra-S DNA Damage Checkpoint Signaling Positive Regulation Of DNA-templated Transcription UV-damage Excision Repair Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing P-body Assembly
Pathways		SUMOylation of DNA damage response and repair proteins DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Hip circumference adjusted for BMI ( 34021172)	Chronotype ( 30696823) Dilated cardiomyopathy ( 33677556) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Offspring birth weight ( 31043758) PR interval ( 32439900) Red blood cell count ( 32888494)
Interacting Genes		18 interacting genes: BTG3 CETN2 DDB2 ERCC3 GTF2H1 LSM3 MDM2 MRPS25 PSMC5 PSMD4 RAD23A RAD23B RPA1 SMAD1 TDG USP7 XPA ZNF512B	45 interacting genes: CCND3 CDKN2D CEP95 CNOT7 DDIT4L DLX4 EEF1A1 EIF4EBP2 EIF4G3 EXOSC1 EXOSC5 GDF9 GSTA1 HSPB1 INCA1 KEAP1 KLF3 LSM1 LSM10 LSM12 LSM2 LSM5 LSM6 LSM7 LSM8 NACC1 PIAS1 QKI SF3B2 SH3GLB2 SMN1 SNRPD3 SNRPE SNRPF SNRPG TCL1A TEPSIN THOC5 TRAPPC2B UTP14A WDR77 WDR83 XPC XRN2 YBX1
Entrez ID		7508	27258
HPRD ID		02046	06283
Ensembl ID		ENSG00000154767	ENSG00000170860
Uniprot IDs		Q01831 X5DRB1	P62310
PDB IDs		2A4J 2GGM 2OBH 2RVB 8EBS 8EBT 8EBU 8EBV 8EBW 8EBX 8EBY	3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair Damaged DNA Binding DNA Repair DNA Damage Response DNA Metabolic Process Nucleoplasm Cellular Response To Stress Nucleic Acid Metabolic Process Macromolecule Metabolic Process Proteasome Complex Nucleus Nucleobase-containing Compound Metabolic Process Regulation Of Proteasomal Protein Catabolic Process XPC Complex Base-excision Repair Polyubiquitin Modification-dependent Protein Binding Response To Stress Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To UV Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process UV-damage Excision Repair UV Protection Transcription Factor TFIIH Core Complex Transcription-coupled Nucleotide-excision Repair Proteasome Regulatory Particle, Base Subcomplex Transcription Factor TFIIH Holo Complex DNA Replication Factor A Complex Cellular Response To UV Proteasomal Protein Catabolic Process Proteasome Accessory Complex Ubiquitin Binding Proteasome Binding Cellular Response To Light Stimulus Single-stranded DNA Binding PML Body Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Light Stimulus Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Cellular Response To Radiation Site Of DNA Damage Response To Radiation Protein-containing Complex Nucleotide-excision Repair Factor 3 Complex	RNA Splicing MRNA Metabolic Process MRNA Processing U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing U4/U6 X U5 Tri-snRNP Complex RNA Binding MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex RNA Metabolic Process Spliceosomal Complex Nucleic Acid Metabolic Process U7 SnRNP Lsm2-8 Complex Precatalytic Spliceosome U6 SnRNP Spliceosomal SnRNP Assembly Catalytic Step 2 Spliceosome Nucleoplasm Methylosome Ribonucleoprotein Complex Lsm1-7-Pat1 Complex Nucleobase-containing Compound Metabolic Process Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex Nucleus MRNA Catabolic Process RNA Catabolic Process Spliceosomal Complex Assembly 7-methylguanosine Cap Hypermethylation U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex U4 SnRNP Protein-RNA Complex Assembly Cytoplasm Macromolecule Metabolic Process U1 SnRNP U5 SnRNP Nucleobase-containing Compound Catabolic Process PICln-Sm Protein Complex Spliceosomal Tri-snRNP Complex U2-type Catalytic Step 2 Spliceosome U6 SnRNA Binding P-body RNA Exonuclease Activity Nuclear-transcribed MRNA Catabolic Process Cytosol U7 SnRNA Binding
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