LSM3 and GDF9

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LSM3	GDF9
Description		LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated	growth differentiation factor 9
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex Ribonucleoprotein Complex	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	RNA Binding Protein Binding U6 SnRNA 3'-end Binding	Cytokine Activity Growth Factor Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing P-body Assembly	Oocyte Growth Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Growth Regulation Of Progesterone Secretion
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Chronotype ( 30696823) Dilated cardiomyopathy ( 33677556) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Offspring birth weight ( 31043758) PR interval ( 32439900) Red blood cell count ( 32888494)	Asthma ( 31619474)
Interacting Genes		45 interacting genes: CCND3 CDKN2D CEP95 CNOT7 DDIT4L DLX4 EEF1A1 EIF4EBP2 EIF4G3 EXOSC1 EXOSC5 GDF9 GSTA1 HSPB1 INCA1 KEAP1 KLF3 LSM1 LSM10 LSM12 LSM2 LSM5 LSM6 LSM7 LSM8 NACC1 PIAS1 QKI SF3B2 SH3GLB2 SMN1 SNRPD3 SNRPE SNRPF SNRPG TCL1A TEPSIN THOC5 TRAPPC2B UTP14A WDR77 WDR83 XPC XRN2 YBX1	46 interacting genes: ACVR2A ADPGK ANXA7 APLP1 BMP15 BMPR1A BMPR1B BMPR2 BTBD2 CDKN1A CDKN2C CRELD1 CRIPTO DLEU1 DNM2 FOXG1 FXYD6 GADD45G HSPA9 ILF3 KDM1A KIF22 LSM3 MOB4 MPHOSPH6 MYCBP NDUFB9 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PMF1 PRKRA PSMD11 RAB27A RSRC1 S100A8 SAT1 SERPINB9 SMN1 SNRPG STRN4 TK1 TRIB3 WASHC3
Entrez ID		27258	2661
HPRD ID		06283	03560
Ensembl ID		ENSG00000170860	ENSG00000164404
Uniprot IDs		P62310	B4DXG3 O60383
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Metabolic Process MRNA Processing U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing U4/U6 X U5 Tri-snRNP Complex RNA Binding MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex RNA Metabolic Process Spliceosomal Complex Nucleic Acid Metabolic Process U7 SnRNP Lsm2-8 Complex Precatalytic Spliceosome U6 SnRNP Spliceosomal SnRNP Assembly Catalytic Step 2 Spliceosome Nucleoplasm Methylosome Ribonucleoprotein Complex Lsm1-7-Pat1 Complex Nucleobase-containing Compound Metabolic Process Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex Nucleus MRNA Catabolic Process RNA Catabolic Process Spliceosomal Complex Assembly 7-methylguanosine Cap Hypermethylation U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex U4 SnRNP Protein-RNA Complex Assembly Cytoplasm Macromolecule Metabolic Process U1 SnRNP U5 SnRNP Nucleobase-containing Compound Catabolic Process PICln-Sm Protein Complex Spliceosomal Tri-snRNP Complex U2-type Catalytic Step 2 Spliceosome U6 SnRNA Binding P-body RNA Exonuclease Activity Nuclear-transcribed MRNA Catabolic Process Cytosol U7 SnRNA Binding	BMP Receptor Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Cellular Response To BMP Stimulus Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Activity, Type II BMP Binding Positive Regulation Of Osteoblast Differentiation Tricuspid Valve Morphogenesis Activin Receptor Signaling Pathway Regulation Of Bone Mineralization BMP Signaling Pathway Transforming Growth Factor Beta Receptor Activity, Type I Negative Regulation Of Chondrocyte Proliferation Regionalization Endochondral Bone Morphogenesis Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Developmental Process Positive Regulation Of SMAD Protein Signal Transduction HFE-transferrin Receptor Complex Mitral Valve Morphogenesis RNA Splicing, Via Transesterification Reactions Regulation Of Ossification Pharyngeal Arch Artery Morphogenesis Osteoblast Differentiation Mesenchyme Development Endocardial Cushion Development Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Positive Regulation Of Programmed Cell Death Pattern Specification Process Regulation Of Osteoblast Differentiation Dorsal/ventral Pattern Formation Cellular Response To Growth Factor Stimulus Regulation Of SMAD Protein Signal Transduction Cellular Developmental Process Cell Differentiation SMN-Sm Protein Complex FAR/SIN/STRIPAK Complex Anterior/posterior Pattern Specification Kinase Activity Precatalytic Spliceosome Atrioventricular Valve Morphogenesis Epithelial Cell Proliferation Protein Binding
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