WNT3 and FZD1

Number of citations of the paper that reports this interaction (PubMedID 10557084)
0

Data Source:
HPRD (in vivo)

		WNT3	FZD1
Description		Wnt family member 3	frizzled class receptor 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Endocytic Vesicle Membrane Extracellular Matrix Extracellular Exosome Bounding Membrane Of Organelle Wnt Signalosome	Plasma Membrane Focal Adhesion Cell Surface Membrane Wnt Signalosome
	Molecular Function	Signaling Receptor Binding Frizzled Binding Cytokine Activity Protein Binding Protein Domain Specific Binding Receptor Ligand Activity	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Signaling Receptor Binding Frizzled Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Wnt Receptor Activity
	Biological Process	Cell Morphogenesis Mesoderm Formation Gamete Generation Axon Guidance Anatomical Structure Morphogenesis Anterior/posterior Axis Specification Dorsal/ventral Axis Specification Anterior/posterior Pattern Specification Gene Expression Positive Regulation Of Gene Expression Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Neuron Differentiation Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Cell Fate Commitment Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Animal Organ Development Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Collateral Sprouting In Absence Of Injury System Development Negative Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Neurogenesis Spemann Organizer Formation At The Anterior End Of The Primitive Streak Canonical Wnt Signaling Pathway Limb Development Limb Bud Formation Head Morphogenesis Mammary Gland Epithelium Development Cellular Response To Retinoic Acid Stem Cell Proliferation Midbrain Dopaminergic Neuron Differentiation Regulation Of Mesenchymal Stem Cell Differentiation	Membranous Septum Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Xenobiotic Stimulus Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Neuron Differentiation Negative Regulation Of BMP Signaling Pathway Autocrine Signaling Non-canonical Wnt Signaling Pathway Astrocyte-dopaminergic Neuron Signaling Endothelial Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Hard Palate Development Canonical Wnt Signaling Pathway Ventricular Septum Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Presynapse Assembly Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Regulation Of Presynapse Assembly Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)	TCF dependent signaling in response to WNT Class B/2 (Secretin family receptors) PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs
Diseases		Tetra-amelia
GWAS		A body shape index ( 34021172) Alcohol consumption (drinks per week) ( 30679032) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease in APOE e4- carriers ( 25778476) Atrial fibrillation ( 30061737) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 28093568) Cortical surface area (global PC1) ( 32198502) Cortical thickness ( 32963231) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Handedness (Left-handed vs. non-left-handed) ( 31504236) Handedness (left-handed vs. right-handed) ( 31504236) Handedness (non-right-handed vs right-handed) ( 31504236) Hematocrit ( 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29785010) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Male-pattern baldness ( 29146897 28196072) Mood instability ( 31168069) Multiple system atrophy ( 27629089) Nonsyndromic cleft lip with or without cleft palate ( 33898419) Parkinson's disease ( 34064523 21812969 22451204) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Post bronchodilator FEV1 ( 26634245) Reaction time ( 29844566) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Blond vs. brown/black hair color ( 30531825) Dental caries ( 23259602) Pulse pressure ( 27841878) Schizophrenia ( 31735061) Systolic blood pressure ( 27841878)
Interacting Genes		2 interacting genes: FZD1 TUBG1	6 interacting genes: DLG2 DLG4 WNT2 WNT3 WNT3A WNT5A
Entrez ID		7473	8321
HPRD ID		01318	04558
Ensembl ID		ENSG00000108379	ENSG00000157240
Uniprot IDs		P56703	Q9UP38
PDB IDs		6AHY	8J9N 8J9O
Enriched GO Terms of Interacting Partners?		Polar Microtubule Gamma-tubulin Ring Complex Gamma-tubulin Complex Microtubule Nucleator Activity Wnt Signalosome Midbrain Dopaminergic Neuron Differentiation Autocrine Signaling Astrocyte-dopaminergic Neuron Signaling Hard Palate Development Glial Cell-neuron Signaling Presynapse Assembly Muscular Septum Morphogenesis Membranous Septum Morphogenesis Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Mitotic Spindle Microtubule Wnt Receptor Activity Presynapse Organization Meiotic Spindle Organization Pericentriolar Material Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Microtubule Nucleation Non-motile Cilium Endothelial Cell Differentiation Wnt-protein Binding Frizzled Binding Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Dopaminergic Neuron Differentiation Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Ventricular Septum Morphogenesis Spindle Microtubule Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Condensed Nuclear Chromosome Non-canonical Wnt Signaling Pathway Nuclear Chromosome Segregation Cytoplasmic Microtubule Cell Leading Edge Outflow Tract Morphogenesis Cytoplasmic Microtubule Organization Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Osteoblast Differentiation Cardiac Septum Morphogenesis Muscle Tissue Morphogenesis Regulation Of Stem Cell Differentiation PDZ Domain Binding Apical Part Of Cell Mitotic Spindle Organization	Midbrain Dopaminergic Neuron Differentiation Frizzled Binding Dopaminergic Neuron Differentiation Negative Regulation Of Axon Extension Involved In Axon Guidance Cellular Response To Retinoic Acid Endocytic Vesicle Membrane Regulation Of Axon Extension Involved In Axon Guidance Canonical Wnt Signaling Pathway Response To Retinoic Acid Receptor Ligand Activity Central Nervous System Neuron Differentiation Negative Regulation Of Axon Extension Positive Regulation Of Collateral Sprouting In Absence Of Injury Cell Fate Commitment Cytokine Activity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Chemotaxis Establishment Or Maintenance Of Apical/basal Cell Polarity Negative Regulation Of Axonogenesis Wnt Signaling Pathway Cell Proliferation In Midbrain Regulation Of Developmental Growth Regulation Of Anatomical Structure Morphogenesis Regulation Of Axon Extension Regulation Of Animal Organ Morphogenesis Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Cell Projection Organization Neuron Differentiation Regulation Of Neurogenesis Negative Regulation Of Developmental Growth Golgi Lumen Signaling Receptor Binding System Development Mammary Gland Epithelium Development Positive Regulation Of Collateral Sprouting Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Neurogenesis Regulation Of Nervous System Development Juxtaparanode Region Of Axon Negative Regulation Of Neuron Projection Development Cellular Response To Lipid Wnt Signalosome Secondary Palate Development Presynapse Assembly Neuron Projection Development Cellular Response To Potassium Ion Negative Regulation Of Neurogenesis Regulation Of Neuron Projection Arborization Negative Regulation Of Nervous System Development Regulation Of Axonogenesis
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