WNT3

Description		Wnt family member 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Endocytic Vesicle Membrane Extracellular Matrix Extracellular Exosome Bounding Membrane Of Organelle Wnt Signalosome
	Molecular Function	Signaling Receptor Binding Frizzled Binding Cytokine Activity Protein Binding Protein Domain Specific Binding Receptor Ligand Activity
	Biological Process	Cell Morphogenesis Mesoderm Formation Gamete Generation Axon Guidance Anatomical Structure Morphogenesis Anterior/posterior Axis Specification Dorsal/ventral Axis Specification Anterior/posterior Pattern Specification Gene Expression Positive Regulation Of Gene Expression Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Neuron Differentiation Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Cell Fate Commitment Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Animal Organ Development Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Collateral Sprouting In Absence Of Injury System Development Negative Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Neurogenesis Spemann Organizer Formation At The Anterior End Of The Primitive Streak Canonical Wnt Signaling Pathway Limb Development Limb Bud Formation Head Morphogenesis Mammary Gland Epithelium Development Cellular Response To Retinoic Acid Stem Cell Proliferation Midbrain Dopaminergic Neuron Differentiation Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)
Drugs
Diseases		Tetra-amelia
GWAS		A body shape index ( 34021172) Alcohol consumption (drinks per week) ( 30679032) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease in APOE e4- carriers ( 25778476) Atrial fibrillation ( 30061737) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 28093568) Cortical surface area (global PC1) ( 32198502) Cortical thickness ( 32963231) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Handedness (Left-handed vs. non-left-handed) ( 31504236) Handedness (left-handed vs. right-handed) ( 31504236) Handedness (non-right-handed vs right-handed) ( 31504236) Hematocrit ( 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29785010) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Male-pattern baldness ( 29146897 28196072) Mood instability ( 31168069) Multiple system atrophy ( 27629089) Nonsyndromic cleft lip with or without cleft palate ( 33898419) Parkinson's disease ( 34064523 21812969 22451204) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Post bronchodilator FEV1 ( 26634245) Reaction time ( 29844566) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Novel Interacting Genes		2 novel interacting genes: FZD1 TUBG1
Interacting Genes		2 interacting genes: FZD1 TUBG1
Entrez ID		7473
HPRD ID		01318
Ensembl ID		ENSG00000108379
Uniprot IDs		P56703
PDB IDs		6AHY
Enriched GO Terms of Interacting Partners?		Polar Microtubule Gamma-tubulin Ring Complex Gamma-tubulin Complex Microtubule Nucleator Activity Wnt Signalosome Midbrain Dopaminergic Neuron Differentiation Autocrine Signaling Astrocyte-dopaminergic Neuron Signaling Hard Palate Development Glial Cell-neuron Signaling Presynapse Assembly Muscular Septum Morphogenesis Membranous Septum Morphogenesis Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Mitotic Spindle Microtubule Wnt Receptor Activity Presynapse Organization Meiotic Spindle Organization Pericentriolar Material Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Microtubule Nucleation Non-motile Cilium Endothelial Cell Differentiation Wnt-protein Binding Frizzled Binding Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Dopaminergic Neuron Differentiation Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Ventricular Septum Morphogenesis Spindle Microtubule Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Condensed Nuclear Chromosome Non-canonical Wnt Signaling Pathway Nuclear Chromosome Segregation Cytoplasmic Microtubule Cell Leading Edge Outflow Tract Morphogenesis Cytoplasmic Microtubule Organization Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Osteoblast Differentiation Cardiac Septum Morphogenesis Muscle Tissue Morphogenesis Regulation Of Stem Cell Differentiation PDZ Domain Binding Apical Part Of Cell Mitotic Spindle Organization
Tagcloud ?