WNT2 and RRAGC

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		WNT2	RRAGC
Description		Wnt family member 2	Ras related GTP binding C
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix Wnt Signalosome	Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Gtr1-Gtr2 GTPase Complex FNIP-folliculin RagC/D GAP
	Molecular Function	Signaling Receptor Binding Frizzled Binding Cytokine Activity Protein Binding Receptor Ligand Activity	Nucleotide Binding Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein-membrane Adaptor Activity Protein Heterodimerization Activity GTPase Binding Molecular Adaptor Activity Enzyme-substrate Adaptor Activity
	Biological Process	Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Mesenchymal Cell Proliferation Wnt Signaling Pathway Neurogenesis Neuron Differentiation Cell Proliferation In Midbrain Cell Fate Commitment Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Animal Organ Development System Development Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Neurogenesis Atrial Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Cardiac Epithelial To Mesenchymal Transition Lung Induction Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Epithelial Cell Proliferation Involved In Lung Morphogenesis Labyrinthine Layer Blood Vessel Development Iris Morphogenesis Mammary Gland Epithelium Development Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus Midbrain Dopaminergic Neuron Differentiation	Autophagosome Assembly Cytoplasmic Translation DNA-templated Transcription Apoptotic Process Lysosome Organization Small GTPase-mediated Signal Transduction Intracellular Protein Localization RNA Splicing Cellular Response To Starvation Negative Regulation Of Autophagy SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Cellular Response To Nutrient Levels Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation TORC1 Signaling Response To Amino Acid Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Protein Localization To Membrane Negative Regulation Of Protein Localization To Nucleus Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)	Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Dupuytren's disease ( 21732829 28886342) Inflammatory bowel disease ( 28067908) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Tonsillectomy ( 27182965 28928442) Ulcerative colitis ( 28067908) Uterine fibroids ( 31649266) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Beard thickness ( 26926045)
Interacting Genes		8 interacting genes: AQP5 FZD1 FZD9 HCK RRAGC SFRP1 UQCR11 WNT3A	7 interacting genes: ATXN1L DEPDC5 MPP3 NOL8 RRAGA RRAGB WNT2
Entrez ID		7472	64121
HPRD ID		00999	12198
Ensembl ID		ENSG00000105989	ENSG00000116954
Uniprot IDs		A0A384MDX3 P09544	B4DQ03 B4DQG4 Q9HB90
PDB IDs			3LLU 6CES 6EHR 6NZD 6S6A 6S6D 6SB0 6SB2 6U62 6ULG 6WJ2 6WJ3 7T3A 7T3B 7T3C 7UX2 7UXC 7UXH 8DHB
Enriched GO Terms of Interacting Partners?		Non-canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway Wnt-protein Binding Dopaminergic Neuron Differentiation Frizzled Binding Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Regulation Of Dopaminergic Neuron Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Presynapse Assembly Wnt Receptor Activity Positive Regulation Of Wnt Signaling Pathway Presynapse Organization Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Cell Surface Regulation Of Cell Junction Assembly Somitogenesis Segmentation Positive Regulation Of Neural Precursor Cell Proliferation Mesoderm Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of BMP Signaling Pathway Convergent Extension Involved In Somitogenesis Neuron Differentiation Negative Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Calcium Ion Transmembrane Transport Via Low Voltage-gated Calcium Channel Positive Regulation Of Mesodermal Cell Fate Specification Regulation Of Animal Organ Morphogenesis Regulation Of Apoptotic Signaling Pathway Signaling Receptor Binding Tissue Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of Neuron Projection Development Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Receptor Clustering Neural Precursor Cell Proliferation Axis Elongation Involved In Somitogenesis Positive Regulation Of Cell Fate Specification Regulation Of Postsynapse To Nucleus Signaling Pathway Paraxial Mesodermal Cell Fate Commitment Positive Regulation Of Collateral Sprouting In Absence Of Injury Cellular Response To Lipid Positive Regulation Of Cellular Component Organization Regulation Of BMP Signaling Pathway	Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling GATOR1 Complex Gtr1-Gtr2 GTPase Complex Positive Regulation Of TOR Signaling Regulation Of TORC1 Signaling Regulation Of TOR Signaling Cellular Response To Starvation Response To Starvation Cellular Response To Nutrient Levels Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein Localization To Lysosome TORC1 Signaling Lysosomal Membrane Regulation Of Autophagy Guanyl Ribonucleotide Binding Cellular Response To Amino Acid Stimulus TOR Signaling Protein Localization To Vacuole Response To Nutrient Levels Lysosome Regulation Of Translational Initiation Negative Regulation Of Autophagy Response To Amino Acid Cytoplasmic Translation Lung Induction Protein Localization To Organelle POZ Domain Binding Positive Regulation Of Translation Cell Proliferation In Midbrain Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Branching Involved In Lung Morphogenesis Negative Regulation Of Translation Cellular Response To Methionine Atrial Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Response To Methionine Intracellular Protein Localization Iris Morphogenesis FNIP-folliculin RagC/D GAP Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of Hematopoietic Stem Cell Proliferation Mammary Gland Epithelium Development Protein Localization To Nucleolus Wnt Signalosome Midbrain Dopaminergic Neuron Differentiation Cellular Response To Leucine Starvation GTPase Activity
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