VARS1 and NEIL3

Number of citations of the paper that reports this interaction (PubMedID 35031058)
59

Data Source:
BioGRID (unspecified method)

		VARS1	NEIL3
Description		valyl-tRNA synthetase 1	nei like DNA glycosylase 3
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Cytosol	Nucleus Nucleoplasm Chromosome
	Molecular Function	Nucleotide Binding Aminoacyl-tRNA Deacylase Activity Aminoacyl-tRNA Ligase Activity Valine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity	Bubble DNA Binding Nucleic Acid Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Catalytic Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Lyase Activity DNA N-glycosylase Activity Metal Ion Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity MCM Complex Binding
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Valyl-tRNA Aminoacylation Aminoacyl-tRNA Metabolism Involved In Translational Fidelity	Single Strand Break Repair DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation DNA Damage Response Interstrand Cross-link Repair Depurination
Pathways		Cytosolic tRNA aminoacylation	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Defective Base Excision Repair Associated with NEIL3 NEIL3-mediated resolution of ICLs NEIL3-mediated resolution of ICLs
Drugs		Valine
Diseases
GWAS			Heart rate variability traits ( 17903306) Idiopathic dilated cardiomyopathy ( 29495422) Mastocytosis (KIT D816V positive) ( 33421400) Metabolite levels ( 23823483)
Interacting Genes		13 interacting genes: CACNA1A CALCOCO2 CAMK2A CDC42 CEBPA DSCR9 EEF1D MTNR1A NEIL3 RNF10 SUMO2 USP7 YWHAQ	54 interacting genes: ACACA BTN1A1 CCN1 CIRBP CKAP4 CPNE8 CSDE1 DHX30 DSC1 EEF1E1-BLOC1S5 EIF2AK2 ELAVL1 FAM120A FXR1 GFAP H2BC21 HBA1 HDLBP HNRNPA0 HNRNPA2B1 HNRNPDL HNRNPR IGF2BP3 KRT13 KRT17 LPL MAP1B MAP4 MBP MYO1C NEDD4L NEFL PIP PLEC PRKDC PRKRA PRRC2A PSPC1 QKI RBMX RECQL RTCA SF1 STAU1 STK36 STRAP STRBP TP53 TWIST1 VARS1 VIM YBX1 YBX3 ZG16B
Entrez ID		7407	55247
HPRD ID		10362	16407
Ensembl ID		ENSG00000204394	ENSG00000109674
Uniprot IDs		A0A024RCN6 P26640	Q8TAT5
PDB IDs			7JL5 7TMY
Enriched GO Terms of Interacting Partners?		Response To Type II Interferon PML Body Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Peptidyl-threonine Autophosphorylation Response To Peptide Response To Cytokine Macrophage Differentiation Substantia Nigra Development Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding MCM Complex Binding	RNA Binding Nucleic Acid Binding Negative Regulation Of MRNA Metabolic Process Negative Regulation Of MRNA Catabolic Process Negative Regulation Of RNA Catabolic Process MRNA Binding MRNA Stabilization RNA Stabilization Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Stability Cytoplasmic Stress Granule Regulation Of RNA Stability Positive Regulation Of Gene Expression Double-stranded RNA Binding Regulation Of MRNA Metabolic Process Regulation Of Translation MRNA 3'-UTR Binding Intermediate Filament Cytoskeleton Positive Regulation Of Translation Intermediate Filament Organization Negative Regulation Of Catabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process CRD-mediated MRNA Stabilization MiRNA Binding Cytosol Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Intermediate Filament RNA Processing Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Protein-containing Complex Organization Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Cellular Component Assembly Spliceosomal Complex Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Translation Positive Regulation Of Biosynthetic Process MiRNA Transport Positive Regulation Of Macromolecule Metabolic Process 3'-UTR-mediated MRNA Stabilization Protein Binding Cytoplasm Negative Regulation Of Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of Nucleobase-containing Compound Metabolic Process
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