UCK2 and ZYG11B

		UCK2	ZYG11B
Description		uridine-cytidine kinase 2	zyg-11 family member B, cell cycle regulator
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding Uridine Kinase Activity ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Cytidine Kinase Activity	Protein Binding
	Biological Process	Feeding Behavior CMP Biosynthetic Process UMP Salvage CTP Salvage Response To Axon Injury Cellular Response To Oxygen Levels	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		Pyrimidine salvage
Drugs		Cytidine Cytidine-5'-Triphosphate Cytidine-5'-Monophosphate Uridine 5'-triphosphate
Diseases
GWAS		Multiple sclerosis ( 31604244) Testicular germ cell tumor ( 23666239 23666240 25877299 28604728 28604732)	Monocyte percentage of white cells ( 32888494)
Interacting Genes		1 interacting genes: ZYG11B	14 interacting genes: ARPC2 ASPA BTBD2 BTF3L4 CFL2 CUL2 ELOB ELOC GBF1 NDC1 OSBPL9 SH2D2A TLR6 UCK2
Entrez ID		7371	79699
HPRD ID		01882	13356
Ensembl ID		ENSG00000143179	ENSG00000162378
Uniprot IDs		A0A2R8Y653 Q9BZX2	A8DPD7 B4DK95 Q9C0D3
PDB IDs		1UDW 1UEI 1UEJ 1UFQ 1UJ2 1XRJ 6N53 6N54 6N55 6PWZ 7SQL	7EP0 7EP1 7EP2 7XV7 7XYV 7XYW 7XYX 7YC2
Enriched GO Terms of Interacting Partners?		Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Cul2-RING Ubiquitin Ligase Complex Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process	Cul2-RING Ubiquitin Ligase Complex Target-directed MiRNA Degradation Elongin Complex Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing MiRNA Catabolic Process Cul5-RING Ubiquitin Ligase Complex MiRNA Metabolic Process Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Aspartoacylase Activity Protein-macromolecule Adaptor Activity Transcription Corepressor Binding Transcription Initiation At RNA Polymerase II Promoter Protein Localization To Endoplasmic Reticulum Tubular Network Diacyl Lipopeptide Binding Nuclear Pore Transmembrane Ring Actin Polymerization Or Depolymerization Cell Leading Edge Actin Cytoskeleton Golgi Apparatus Subcompartment Endoplasmic Reticulum-Golgi Intermediate Compartment Organization Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Detection Of Diacyl Bacterial Lipopeptide DNA-templated Transcription Initiation Acetate Metabolic Process Cytosol VCB Complex CTP Salvage Muscle Cell Projection Membrane Actin Filament Fragmentation Cytidine Kinase Activity Uridine Kinase Activity CMP Biosynthetic Process Endomembrane System Organization Toll-like Receptor 2 Binding Detection Of Bacterial Lipoprotein Toll-like Receptor TLR6:TLR2 Signaling Pathway
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