ZYG11B and ARPC2

		ZYG11B	ARPC2
Description		zyg-11 family member B, cell cycle regulator	actin related protein 2/3 complex subunit 2
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GO Annotations	Cellular Component	Cytoplasm Cul2-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Cytoskeleton Arp2/3 Protein Complex Plasma Membrane Focal Adhesion Actin Cytoskeleton Lamellipodium Synaptic Vesicle Membrane Cell Leading Edge Site Of Double-strand Break Muscle Cell Projection Membrane Cell Projection Neuron Projection Synapse Extracellular Exosome Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding
	Biological Process	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Positive Regulation Of Lamellipodium Assembly Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cellular Component Organization Actin Polymerization-dependent Cell Motility Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways			Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs			N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Monocyte percentage of white cells ( 32888494)	Inflammatory bowel disease ( 23128233 28067908) Mean platelet volume ( 27863252 32888494) Neutrophil count ( 29403010) Obesity-related traits ( 23251661) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) White blood cell count ( 25096241 29403010)
Interacting Genes		14 interacting genes: ARPC2 ASPA BTBD2 BTF3L4 CFL2 CUL2 ELOB ELOC GBF1 NDC1 OSBPL9 SH2D2A TLR6 UCK2	10 interacting genes: ACTR3 ARPC1B ARPC4 AURKA CORO1B MDN1 NFE2L2 SHANK3 WAS ZYG11B
Entrez ID		79699	10109
HPRD ID		13356	10367
Ensembl ID		ENSG00000162378	ENSG00000163466
Uniprot IDs		A8DPD7 B4DK95 Q9C0D3	O15144 Q53R19
PDB IDs		7EP0 7EP1 7EP2 7XV7 7XYV 7XYW 7XYX 7YC2	6UHC 6YW6 6YW7 8P94
Enriched GO Terms of Interacting Partners?		Cul2-RING Ubiquitin Ligase Complex Target-directed MiRNA Degradation Elongin Complex Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing MiRNA Catabolic Process Cul5-RING Ubiquitin Ligase Complex MiRNA Metabolic Process Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Aspartoacylase Activity Protein-macromolecule Adaptor Activity Transcription Corepressor Binding Transcription Initiation At RNA Polymerase II Promoter Protein Localization To Endoplasmic Reticulum Tubular Network Diacyl Lipopeptide Binding Nuclear Pore Transmembrane Ring Actin Polymerization Or Depolymerization Cell Leading Edge Actin Cytoskeleton Golgi Apparatus Subcompartment Endoplasmic Reticulum-Golgi Intermediate Compartment Organization Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Detection Of Diacyl Bacterial Lipopeptide DNA-templated Transcription Initiation Acetate Metabolic Process Cytosol VCB Complex CTP Salvage Muscle Cell Projection Membrane Actin Filament Fragmentation Cytidine Kinase Activity Uridine Kinase Activity CMP Biosynthetic Process Endomembrane System Organization Toll-like Receptor 2 Binding Detection Of Bacterial Lipoprotein Toll-like Receptor TLR6:TLR2 Signaling Pathway	Actin Binding Arp2/3 Protein Complex Arp2/3 Complex-mediated Actin Nucleation Actin Filament Organization Actin Nucleation Regulation Of Lamellipodium Organization Supramolecular Fiber Organization Actin Filament Binding Actin Cytoskeleton Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Site Of Double-strand Break Structural Constituent Of Cytoskeleton Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cytoskeleton Cellular Component Assembly Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Cytoplasm Negative Regulation Of Smooth Muscle Cell Migration Actin Filament Polymerization Positive Regulation Of Lamellipodium Organization Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Cytosol Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Lamellipodium Assembly Positive Regulation Of Cellular Component Organization Regulation Of Actin Filament Organization Actin Polymerization Or Depolymerization Positive Regulation Of Glutathione Biosynthetic Process Regulation Of T Cell Antigen Processing And Presentation Tubulobulbar Complex Actin Filament Branching Regulation Of Smooth Muscle Cell Migration Cellular Response To Type II Interferon Negative Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Organization Protein Polymerization Regulation Of Cellular Component Organization Regulation Of Anatomical Structure Morphogenesis Regulation Of Protein Catabolic Process Negative Regulation Of Locomotion Regulation Of Glutathione Biosynthetic Process Regulation Of Proteolysis Positive Regulation Of Cell Projection Organization
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