UGT2B7 and GABRA3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		UGT2B7	GABRA3
Description		UDP glucuronosyltransferase family 2 member B7	gamma-aminobutyric acid type A receptor subunit alpha3
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Plasma Membrane Membrane Dendrite Membrane Chloride Channel Complex Synapse Postsynaptic Membrane Postsynapse GABA-ergic Synapse Postsynaptic Specialization Membrane GABA-A Receptor Complex
	Molecular Function	Retinoic Acid Binding UDP-glycosyltransferase Activity Glucuronosyltransferase Activity Transferase Activity Glycosyltransferase Activity	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Protein Binding Benzodiazepine Receptor Activity GABA-gated Chloride Ion Channel Activity Signaling Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Lipid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process	Monoatomic Ion Transport Chloride Transport Gamma-aminobutyric Acid Signaling Pathway Monoatomic Ion Transmembrane Transport Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Chloride Transmembrane Transport Inhibitory Synapse Assembly
Pathways		Glucuronidation Aspirin ADME Prednisone ADME	GABA receptor activation GABA receptor activation
Drugs			Lorazepam Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Butalbital Phenytoin Etomidate Talbutal Talbutal Pentobarbital Pentobarbital Olanzapine Clobazam Clobazam Meprobamate Meprobamate Carisoprodol Eszopiclone Eszopiclone Alprazolam Alprazolam Secobarbital Zolpidem Metharbital Metharbital Chlordiazepoxide Chlordiazepoxide Amoxapine Adinazolam Adinazolam Lamotrigine Lamotrigine Thiopental Medroxyprogesterone acetate Clorazepic acid Clorazepic acid Midazolam Midazolam Flurazepam Flurazepam Isoflurane Primidone Primidone Halazepam Halazepam Propofol Diazepam Diazepam Oxazepam Oxazepam Methylphenobarbital Triazolam Triazolam Ethanol Zonisamide Methoxyflurane Memantine Clonazepam Clonazepam Methyprylon Halothane Desflurane Zopiclone Flumazenil Estazolam Estazolam Sevoflurane Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Glutethimide Barbital Camazepam Camazepam Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Delorazepam Delorazepam Flunitrazepam Flunitrazepam Ethyl loflazepate Ethyl loflazepate Cloxazolam Cloxazolam Bromazepam Bromazepam Clotiazepam Clotiazepam Fludiazepam Ketazolam Ketazolam Prazepam Prazepam Quazepam Quazepam Cinolazepam Cinolazepam Nitrazepam Nitrazepam Prasterone Taurine Pagoclone Ganaxolone Adipiplon Brotizolam Brotizolam Stiripentol Etizolam Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Remimazolam 1,2-Benzodiazepine 1,2-Benzodiazepine Pinazepam Pinazepam Medazepam Medazepam Loprazolam Loprazolam Doxefazepam Doxefazepam Lormetazepam Lormetazepam 5,7,2′-trihydroxy-6,8-dimethoxyflavone AZD-7325 Nordazepam Nordazepam Oxazepam acetate Oxazepam acetate Cinazepam Cinazepam Bentazepam Bentazepam Mexazolam Mexazolam
Diseases
GWAS		AR-C124910XX levels in individuals with acute coronary syndromes treated with ticagrelor ( 25935875) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Estradiol levels ( 34255042) Gamma glutamyl transferase levels ( 33339817) Liver enzyme levels (alkaline phosphatase) ( 33972514) Obesity-related traits ( 23251661) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		2 interacting genes: CYP3A4 GABRA3	3 interacting genes: SDCBP2 UBQLN1 UGT2B7
Entrez ID		7364	2556
HPRD ID		02508	02375
Ensembl ID		ENSG00000171234	ENSG00000011677
Uniprot IDs		E9PBP8 P16662	P34903
PDB IDs		2O6L	9CTP
Enriched GO Terms of Interacting Partners?		Vitamin D Biosynthetic Process Quinine 3-monooxygenase Activity Anandamide 8,9 Epoxidase Activity Calcitriol Biosynthetic Process From Calciol Vitamin D 24-hydroxylase Activity Anandamide 11,12 Epoxidase Activity Vitamin D Catabolic Process 1,8-cineole 2-exo-monooxygenase Activity Anandamide 14,15 Epoxidase Activity Alkaloid Catabolic Process Vitamin D3 25-hydroxylase Activity 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase Activity Caffeine Oxidase Activity Testosterone 6-beta-hydroxylase Activity Oxidative Demethylation Vitamin D3 Metabolic Process Retinoic Acid 4-hydroxylase Activity Monoterpenoid Metabolic Process Aflatoxin Metabolic Process Lipid Hydroxylation Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity Alkaloid Metabolic Process Demethylation Benzodiazepine Receptor Activity Vitamin D Metabolic Process Steroid Hydroxylase Activity Toxin Metabolic Process GABA-gated Chloride Ion Channel Activity GABA-A Receptor Activity GABA-A Receptor Complex Retinoic Acid Metabolic Process Xenobiotic Catabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Vitamin Metabolic Process Oxygen Binding Androgen Metabolic Process Steroid Catabolic Process Gamma-aminobutyric Acid Signaling Pathway Inhibitory Synapse Assembly Steroid Binding Postsynaptic Specialization Membrane Dendrite Membrane Synaptic Transmission, GABAergic Estrogen Metabolic Process Extracellular Ligand-gated Monoatomic Ion Channel Activity Long-chain Fatty Acid Biosynthetic Process Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Secondary Metabolic Process Retinol Metabolic Process	Negative Regulation Of Store-operated Calcium Channel Activity
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