UBA7 and DNAL4

		UBA7	DNAL4
Description		ubiquitin like modifier activating enzyme 7	dynein axonemal light chain 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm Cytoskeleton Microtubule Plasma Membrane Cilium Dynein Complex Cell Projection
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity ISG15 Activating Enzyme Activity	Microtubule Motor Activity Protein Binding Identical Protein Binding
	Biological Process	DNA Damage Response Protein Ubiquitination Modification-dependent Protein Catabolic Process ISG15-protein Conjugation Innate Immune Response	Microtubule-based Process Microtubule-based Movement
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation Modulation of host responses by IFN-stimulated genes	Retrograde neurotrophin signalling
Drugs
Diseases
GWAS		Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) Menarche (age at onset) ( 25231870) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 21297633) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		8 interacting genes: DNAL4 FAS ISG15 LCOR RSPH1 UBE2E1 UBE2L3 UBE2L6	23 interacting genes: CACNA1I CHIC2 DDX17 DYNLL2 FHL5 GNA14 GPBP1 GTPBP1 HMGXB4 JOSD1 KRTAP10-3 KRTAP12-3 KRTAP9-8 NFATC2IP NOTCH2NLA NTAQ1 NUDT22 RHOT2 SCTR TOM1 TRIM54 TRIOBP UBA7
Entrez ID		7318	10126
HPRD ID		01873	13239
Ensembl ID		ENSG00000182179	ENSG00000100246
Uniprot IDs		P41226	O96015
PDB IDs		8OIF 8SE9 8SEA 8SEB 8SV8 8WWX
Enriched GO Terms of Interacting Partners?		ISG15-protein Conjugation Ubiquitin Conjugating Enzyme Activity ISG15 Transferase Activity Ubiquitin-like Protein Transferase Activity Modification-dependent Protein Catabolic Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Polyubiquitination Post-translational Protein Modification Macromolecule Catabolic Process Fas Signaling Pathway Ubiquitin Ligase Complex Proteolysis Radial Spoke Head 1 Radial Spoke Head 3 Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Oligomerization Cellular Response To Hyperoxia Radial Spoke Head CD95 Death-inducing Signaling Complex Death-inducing Signaling Complex Activation-induced Cell Death Of T Cells Outer Dense Fiber Regulation Of Protein Ubiquitination Necroptotic Signaling Pathway Protein Modification Process Ubiquitin-protein Transferase Activator Activity
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