DNAL4 and GTPBP1

		DNAL4	GTPBP1
Description		dynein axonemal light chain 4	GTP binding protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Microtubule Plasma Membrane Cilium Dynein Complex Cell Projection	Cytoplasmic Exosome (RNase Complex) Cytoplasm Cytosol Membrane
	Molecular Function	Microtubule Motor Activity Protein Binding Identical Protein Binding	TRNA Binding Nucleotide Binding RNA Binding Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Alpha-aminoacyl-tRNA Binding
	Biological Process	Microtubule-based Process Microtubule-based Movement	Cytoplasmic Translation Translational Elongation Immune Response Signal Transduction GTP Metabolic Process Positive Regulation Of MRNA Catabolic Process RNA Surveillance
Pathways		Retrograde neurotrophin signalling
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) C-reactive protein levels ( 30388399) Diverticular disease ( 30177863) Hand grip strength ( 29691431) Hip circumference adjusted for BMI ( 34021172) Mean reticulocyte volume ( 32888494) Resting heart rate ( 27798624) Sleep duration ( 30846698)
Interacting Genes		23 interacting genes: CACNA1I CHIC2 DDX17 DYNLL2 FHL5 GNA14 GPBP1 GTPBP1 HMGXB4 JOSD1 KRTAP10-3 KRTAP12-3 KRTAP9-8 NFATC2IP NOTCH2NLA NTAQ1 NUDT22 RHOT2 SCTR TOM1 TRIM54 TRIOBP UBA7	7 interacting genes: APP C7orf25 CACNA1I CEBPA DNAL4 LRP1 WEE2-AS1
Entrez ID		10126	9567
HPRD ID		13239	03765
Ensembl ID		ENSG00000100246	ENSG00000100226
Uniprot IDs		O96015	O00178
PDB IDs
Enriched GO Terms of Interacting Partners?			Astrocyte Activation Involved In Immune Response Heparan Sulfate Proteoglycan Binding Apolipoprotein Binding Regulation Of Amyloid-beta Clearance Astrocyte Activation Positive Regulation Of Protein Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Clathrin-coated Pit Cellular Response To Amyloid-beta Regulation Of Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Memory Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization CHOP-C/EBP Complex Response To Vitamin B2 C/EBP Complex Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Lipoprotein Particle Receptor Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Inflammatory Response Axon Midline Choice Point Recognition Cell Activation Involved In Immune Response Positive Regulation Of Amyloid Fibril Formation Cell Maturation Positive Regulation Of Endocytosis
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