TNFSF4 and SOAT1

		TNFSF4	SOAT1
Description		TNF superfamily member 4	sterol O-acyltransferase 1
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GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell Surface Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding	Fatty-acyl-CoA Binding Sterol O-acyltransferase Activity Protein Binding O-acyltransferase Activity Cholesterol Binding Transferase Activity Acyltransferase Activity Cholesterol O-acyltransferase Activity Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cytokine Production Defense Response To Nematode Acute Inflammatory Response Positive Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Cytokine Production Regulation Of Adaptive Immune Response Positive Regulation Of Type 2 Immune Response Positive Regulation Of Immunoglobulin Mediated Immune Response Inflammatory Response Immune Response Cell Communication Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Virus Signaling Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Chemokine Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Memory T Cell Activation T-helper 2 Cell Activation Response To Nitrogen Dioxide Positive Regulation Of T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Memory T Cell Differentiation Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of B Cell Activation Cellular Response To Lipopolysaccharide Cellular Response To Prostaglandin E Stimulus Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes	Lipid Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Macrophage Derived Foam Cell Differentiation Cholesterol Storage Cholesterol Efflux Very-low-density Lipoprotein Particle Assembly Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process
Pathways		TNFs bind their physiological receptors	LDL clearance
Drugs			Ezetimibe Hesperetin
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Alopecia areata ( 25337690) Asthma ( 32296059 31361310 27182965 30929738 34103634) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Celiac disease ( 20190752 24999842) Crohn's disease ( 21102463) Diabetic retinopathy ( 21441570) IgA levels ( 28628107) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 28714469 19838193 27399966 26663301 26502338 23273568 32771030 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989) Vein graft stenosis in coronary artery bypass grafting ( 25881214)	Metabolite levels ( 23823483)
Interacting Genes		10 interacting genes: CERS2 COLGALT2 IL10 LTB4R PACSIN3 SMG7 SOAT1 TNFRSF4 TPR TRAF2	2 interacting genes: TERF1 TNFSF4
Entrez ID		7292	6646
HPRD ID		04668	00033
Ensembl ID		ENSG00000117586	ENSG00000057252
Uniprot IDs		A0A024R937 P23510	P35610
PDB IDs		2HEV	6L47 6L48 6P2J 6P2P 6VUM
Enriched GO Terms of Interacting Partners?		Regulation Of Immunoglobulin Production Regulation Of Membrane Protein Ectodomain Proteolysis Leukotriene Signaling Pathway Leukotriene B4 Receptor Activity Leukotriene Receptor Activity Positive Regulation Of Immune Effector Process Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Involved In Immune Response Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of Chronic Inflammatory Response Regulation Of B Cell Proliferation Regulation Of Production Of Molecular Mediator Of Immune Response Negative Regulation Of Receptor Binding Regulation Of Protein Metabolic Process Interleukin-10 Receptor Binding Mononuclear Cell Proliferation Lymphocyte Activation Negative Regulation Of Interleukin-18 Production Positive Regulation Of Immunoglobulin Production Negative Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Lymphocyte Proliferation Response To Carbon Monoxide Negative Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of B Cell Apoptotic Process Negative Regulation Of Interferon-alpha Production Negative Regulation Of Cytokine Activity Positive Regulation Of B Cell Activation Regulation Of Cytokine Activity Positive Regulation Of Plasma Cell Differentiation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Cholesterol Storage Sterol O-acyltransferase Activity Cholesterol O-acyltransferase Activity RNA Export From Nucleus Nuclear Export Positive Regulation Of Chromatin Organization Negative Regulation Of RNA Export From Nucleus Positive Regulation Of Heterochromatin Formation MRNA Export From Nucleus MRNA Transport MRNA Export From Nucleus In Response To Heat Stress Nuclear Matrix Organization RNA Import Into Nucleus Sphingolipid Binding TORC2 Complex Disassembly Tumor Necrosis Factor-mediated Signaling Pathway TRAF2-GSTP1 Complex IRE1-TRAF2-ASK1 Complex TORC1 Complex Assembly CD40 Receptor Binding	Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation T-helper 2 Cell Activation Response To Nitrogen Dioxide Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Memory T Cell Activation Positive Regulation Of T Cell Costimulation Positive Regulation Of DNA Metabolic Process Defense Response To Nematode Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Isotype Switching To IgE Isotypes Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of DNA Metabolic Process Regulation Of Establishment Of Protein Localization To Telomere Telomerase Activity Shelterin Complex Ankyrin Repeat Binding Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Tumor Necrosis Factor Receptor Superfamily Binding Nuclear Telomere Cap Complex Telomere Localization Meiotic Telomere Clustering Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Positive Regulation Of Memory T Cell Differentiation G-rich Strand Telomeric DNA Binding T-circle Formation Telomeric Loop Disassembly Telomere Capping Regulation Of Memory T Cell Differentiation Negative Regulation Of T-helper 1 Type Immune Response Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Interleukin-13 Production DNA Binding, Bending Negative Regulation Of Interleukin-17 Production Positive Regulation Of Type 2 Immune Response Cellular Response To Prostaglandin E Stimulus Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of T-helper Cell Differentiation Telomere Maintenance Via Telomerase Negative Regulation Of DNA Replication RNA-templated DNA Biosynthetic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
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