SOAT1

Description		sterol O-acyltransferase 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Fatty-acyl-CoA Binding Sterol O-acyltransferase Activity Protein Binding O-acyltransferase Activity Cholesterol Binding Transferase Activity Acyltransferase Activity Cholesterol O-acyltransferase Activity Identical Protein Binding
	Biological Process	Lipid Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Macrophage Derived Foam Cell Differentiation Cholesterol Storage Cholesterol Efflux Very-low-density Lipoprotein Particle Assembly Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process
Pathways		LDL clearance
Drugs		Ezetimibe Hesperetin
Diseases
GWAS		Metabolite levels ( 23823483)
Novel Interacting Genes		2 novel interacting genes: TERF1 TNFSF4
Interacting Genes		2 interacting genes: TERF1 TNFSF4
Entrez ID		6646
HPRD ID		00033
Ensembl ID		ENSG00000057252
Uniprot IDs		P35610
PDB IDs		6L47 6L48 6P2J 6P2P 6VUM
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation T-helper 2 Cell Activation Response To Nitrogen Dioxide Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Memory T Cell Activation Positive Regulation Of T Cell Costimulation Positive Regulation Of DNA Metabolic Process Defense Response To Nematode Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Isotype Switching To IgE Isotypes Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of DNA Metabolic Process Regulation Of Establishment Of Protein Localization To Telomere Telomerase Activity Shelterin Complex Ankyrin Repeat Binding Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Tumor Necrosis Factor Receptor Superfamily Binding Nuclear Telomere Cap Complex Telomere Localization Meiotic Telomere Clustering Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Positive Regulation Of Memory T Cell Differentiation G-rich Strand Telomeric DNA Binding T-circle Formation Telomeric Loop Disassembly Telomere Capping Regulation Of Memory T Cell Differentiation Negative Regulation Of T-helper 1 Type Immune Response Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Interleukin-13 Production DNA Binding, Bending Negative Regulation Of Interleukin-17 Production Positive Regulation Of Type 2 Immune Response Cellular Response To Prostaglandin E Stimulus Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of T-helper Cell Differentiation Telomere Maintenance Via Telomerase Negative Regulation Of DNA Replication RNA-templated DNA Biosynthetic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
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