C5 and SARDH

		C5	SARDH
Description		complement C5	sarcosine dehydrogenase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Membrane Other Organism Cell Membrane Extracellular Exosome Transmembrane Transporter Complex	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	G Protein-coupled Receptor Binding Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Chemokine Activity Receptor Ligand Activity	Sarcosine Dehydrogenase Activity Oxidoreductase Activity
	Biological Process	Complement Activation, Lectin Pathway Immune System Process Regulation Of Immune System Process Chemotaxis Inflammatory Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macrophage Chemotaxis Cell Migration Leukocyte Chemotaxis Killing Of Cells Of Another Organism Positive Regulation Of Chemokine Production Innate Immune Response Regulation Of Chemotaxis Cell Chemotaxis Complement Activation, GZMK Pathway	Sarcosine Catabolic Process
Pathways		Terminal pathway of complement Activation of C3 and C5 Peptide ligand-binding receptors G alpha (i) signalling events Regulation of Complement cascade	Choline catabolism
Drugs		Human immunoglobulin G Eculizumab Zinc Copper Ravulizumab Zinc acetate Zinc chloride Zinc sulfate, unspecified form Zilucoplan Vilobelimab
Diseases		Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS		Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Hip circumference adjusted for BMI ( 25673412) Pulse pressure ( 27841878) Refractive error ( 32231278) Rheumatoid arthritis ( 19503088 24390342 30891314)	Asthma ( 27611488) Post bronchodilator FEV1/FVC ratio ( 26634245) Serum metabolite levels ( 33031748)
Interacting Genes		31 interacting genes: ANKS6 AQP6 C2 C3 C5AR1 C6 C7 C8B CPB2 CPLX4 CPN1 CREB3L1 EBP KEL KIR3DL3 LIMK1 LMNA LRSAM1 MMGT1 NEK6 NEMP1 PGRMC2 PIGP POU6F2 PRDM16 PRKCZ SARDH SLC10A2 SPTAN1 SSMEM1 VEZT	1 interacting genes: C5
Entrez ID		727	1757
HPRD ID		00405	06831
Ensembl ID		ENSG00000106804	ENSG00000123453
Uniprot IDs		A0A8Q3SID6 P01031 Q59GS8	A8K596 Q9UL12
PDB IDs		1CFA 1KJS 1XWE 3CU7 3HQA 3HQB 3KLS 3KM9 3PRX 3PVM 4A5W 4E0S 4P39 4UU9 5B4P 5B71 5HCC 5HCD 5HCE 5I5K 6H03 6H04 6RPT 6RQJ 7AD6 7AD7 7NYC 7NYD 7Y64 8B0F 8B0G 8B0H 8HK5 8HQC 8IA2 8JZZ
Enriched GO Terms of Interacting Partners?		Complement Activation, GZMK Pathway Complement Activation, Classical Pathway Complement Activation Membrane Attack Complex Other Organism Cell Membrane Transmembrane Transporter Complex Killing Of Cells Of Another Organism Complement Activation, Alternative Pathway Activation Of Immune Response Classical-complement-pathway C3/C5 Convertase Complex Positive Regulation Of Immune Response Cell Killing Regulation Of Immune Response Nuclear Envelope Immune Effector Process Positive Regulation Of Apoptotic Cell Clearance Humoral Immune Response Regulation Of Apoptotic Cell Clearance Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Complement Receptor Mediated Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Immune System Process Opsonization Symbiont Cell Surface Metallocarboxypeptidase Activity Amyloid-beta Clearance	Complement Activation, Lectin Pathway Transmembrane Transporter Complex Negative Regulation Of Macrophage Migration Complement Activation, GZMK Pathway Other Organism Cell Membrane Negative Regulation Of Macrophage Chemotaxis Membrane Attack Complex Complement Activation, Alternative Pathway Negative Regulation Of Leukocyte Chemotaxis Negative Regulation Of Chemotaxis Positive Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Macrophage Migration Chemokine Activity Complement Activation, Classical Pathway Endopeptidase Inhibitor Activity Regulation Of Macrophage Chemotaxis Negative Regulation Of Mononuclear Cell Migration Negative Regulation Of Leukocyte Migration Complement Activation G Protein-coupled Receptor Binding Positive Regulation Of Chemokine Production Regulation Of Chemokine Production Receptor Ligand Activity Killing Of Cells Of Another Organism Leukocyte Chemotaxis Regulation Of Mononuclear Cell Migration Cell Killing Cell Chemotaxis Regulation Of Chemotaxis Regulation Of Leukocyte Migration Leukocyte Migration Humoral Immune Response
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