C5 and LIMK1

		C5	LIMK1
Description		complement C5	LIM domain kinase 1
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GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Membrane Other Organism Cell Membrane Extracellular Exosome Transmembrane Transporter Complex	Male Germ Cell Nucleus Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Nuclear Speck Lamellipodium Cell Junction Cell Projection Neuron Projection Postsynapse Glutamatergic Synapse
	Molecular Function	G Protein-coupled Receptor Binding Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Chemokine Activity Receptor Ligand Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Protein Serine Kinase Activity Ubiquitin Ligase Inhibitor Activity
	Biological Process	Complement Activation, Lectin Pathway Immune System Process Regulation Of Immune System Process Chemotaxis Inflammatory Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macrophage Chemotaxis Cell Migration Leukocyte Chemotaxis Killing Of Cells Of Another Organism Positive Regulation Of Chemokine Production Innate Immune Response Regulation Of Chemotaxis Cell Chemotaxis Complement Activation, GZMK Pathway	Protein Phosphorylation Signal Transduction Rho Protein Signal Transduction Nervous System Development Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stress Fiber Assembly Positive Regulation Of Axon Extension Axon Extension Positive Regulation Of Stress Fiber Assembly
Pathways		Terminal pathway of complement Activation of C3 and C5 Peptide ligand-binding receptors G alpha (i) signalling events Regulation of Complement cascade	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion Sema3A PAK dependent Axon repulsion Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs RHO GTPases activate PAKs
Drugs		Human immunoglobulin G Eculizumab Zinc Copper Ravulizumab Zinc acetate Zinc chloride Zinc sulfate, unspecified form Zilucoplan Vilobelimab	Dabrafenib Fostamatinib
Diseases		Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS		Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Hip circumference adjusted for BMI ( 25673412) Pulse pressure ( 27841878) Refractive error ( 32231278) Rheumatoid arthritis ( 19503088 24390342 30891314)	Pulse pressure ( 30224653) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		31 interacting genes: ANKS6 AQP6 C2 C3 C5AR1 C6 C7 C8B CPB2 CPLX4 CPN1 CREB3L1 EBP KEL KIR3DL3 LIMK1 LMNA LRSAM1 MMGT1 NEK6 NEMP1 PGRMC2 PIGP POU6F2 PRDM16 PRKCZ SARDH SLC10A2 SPTAN1 SSMEM1 VEZT	33 interacting genes: ABCA1 APP ARRB1 ARRB2 BMPR2 C5 CDC42BPA CDKN1C CFL1 CFL2 DSCAM FBXO7 H1-1 HUNK LATS1 LIMK2 MAPK14 MAPKAPK2 MBP MFHAS1 NRG1 PAK1 PAK2 PAK4 PAK6 PXN RLIM ROCK1 SELENOS SRPK1 SSH3 WASHC1 YWHAZ
Entrez ID		727	3984
HPRD ID		00405	03210
Ensembl ID		ENSG00000106804	ENSG00000106683
Uniprot IDs		A0A8Q3SID6 P01031 Q59GS8	P53667
PDB IDs		1CFA 1KJS 1XWE 3CU7 3HQA 3HQB 3KLS 3KM9 3PRX 3PVM 4A5W 4E0S 4P39 4UU9 5B4P 5B71 5HCC 5HCD 5HCE 5I5K 6H03 6H04 6RPT 6RQJ 7AD6 7AD7 7NYC 7NYD 7Y64 8B0F 8B0G 8B0H 8HK5 8HQC 8IA2 8JZZ	3S95 5HVJ 5HVK 5L6W 5NXC 6WLY 7ATS 7ATU 7B8W 8AAU
Enriched GO Terms of Interacting Partners?		Complement Activation, GZMK Pathway Complement Activation, Classical Pathway Complement Activation Membrane Attack Complex Other Organism Cell Membrane Transmembrane Transporter Complex Killing Of Cells Of Another Organism Complement Activation, Alternative Pathway Activation Of Immune Response Classical-complement-pathway C3/C5 Convertase Complex Positive Regulation Of Immune Response Cell Killing Regulation Of Immune Response Nuclear Envelope Immune Effector Process Positive Regulation Of Apoptotic Cell Clearance Humoral Immune Response Regulation Of Apoptotic Cell Clearance Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Complement Receptor Mediated Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Immune System Process Opsonization Symbiont Cell Surface Metallocarboxypeptidase Activity Amyloid-beta Clearance	Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Positive Regulation Of Cellular Component Organization Protein Kinase Activity Regulation Of Cellular Component Organization Kinase Activity Intracellular Signal Transduction Regulation Of Actin Filament Organization Regulation Of Supramolecular Fiber Organization Signal Transduction Regulation Of Actin Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Process Regulation Of Actin Filament-based Process Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling ATP Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Developmental Growth Nucleotide Binding Actin Cytoskeleton Organization Regulation Of Interleukin-6 Production Regulation Of Protein Localization To Nucleus Regulation Of Cytoskeleton Organization Actin Filament-based Process Cellular Response To Starvation Transferase Activity Regulation Of Growth Response To Growth Factor Negative Regulation Of Protein Localization To Nucleus Regulation Of Developmental Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Response To Nutrient Levels Dendritic Spine Development Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Cell Projection Organization Angiotensin Receptor Binding Protein Phosphorylation Regulation Of Receptor-mediated Endocytosis Response To Starvation Positive Regulation Of Cellular Component Biogenesis Phosphorylation Positive Regulation Of Growth Regulation Of Immune Response Regulation Of Organelle Organization Cellular Response To Nutrient Levels Regulation Of Phosphorus Metabolic Process Clathrin-coated Pit
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