CCT3 and UBE2Z

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCT3	UBE2Z
Description		chaperonin containing TCP1 subunit 3	ubiquitin conjugating enzyme E2 Z
Image
GO Annotations	Cellular Component	Zona Pellucida Receptor Complex Cytoplasm Cytosol Chaperonin-containing T-complex Cytoskeleton Microtubule Cell Body Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Molecular Adaptor Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester Artenimol
Diseases
GWAS		Basophil count ( 32888494) Glycated hemoglobin levels ( 24647736) Household income (MTAG) ( 31844048) Mean corpuscular hemoglobin concentration ( 20139978) Mean corpuscular volume ( 29403010) Red blood cell count ( 29403010) Red cell distribution width ( 32888494) Subcutaneous adipose tissue ( 22589738) Walking pace ( 33128006)	Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Myocardial infarction ( 26343387) Platelet count ( 32888494) Plateletcrit ( 32888494) Type 2 diabetes ( 29358691 30054458)
Interacting Genes		26 interacting genes: BUD31 CEBPA DEPDC5 EIF2B2 ERBB2 FANCA GEMIN4 HNRNPA0 HSPA8 LINC01554 LNX2 MAPK6 MIPOL1 OGT PAFAH1B2 POLR1C PTEN RAF1 SH3BP4 SHANK3 SUMO2 UBE2Z VAV2 VHL XRCC6 ZNRD2	40 interacting genes: AK8 BMPR1B CCT3 DZIP3 GORASP2 HLTF HMBOX1 HUWE1 INCA1 LNX2 LPL MDM2 OTUB1 PLEKHA6 PLEKHF2 PPP1CA PRKN RAPSN REL RNF103 RNF130 RNF139 RNF144B RNF150 RNF166 RNF41 RNF5 SMAD1 SMAD4 SRA1 SYVN1 TGFBR1 TRAIP TRIM27 TRIM3 TRIM46 TRIM65 UBA1 UBA6 UBD
Entrez ID		7203	65264
HPRD ID		08969	08589
Ensembl ID		ENSG00000163468	ENSG00000159202
Uniprot IDs		B3KX11 P49368 Q59H77	Q9H832
PDB IDs		6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP 7NVL 7NVM 7NVN 7NVO 7TRG 7TTN 7TTT 7TUB 7WU7 7WZ3 7X0A 7X0S 7X0V 7X3J 7X3U 7X6Q 7X7Y 8HKI 8I1U 8I6J 8I9U 8IB8 8SFE 8SFF 8SG8 8SG9 8SGC 8SGL 8SGQ 8SH9 8SHA 8SHD 8SHE 8SHF 8SHG 8SHL 8SHN 8SHO 8SHP 8SHQ 8SHT	5A4P
Enriched GO Terms of Interacting Partners?		Protein Localization To Lysosome Positive Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Protein Localization To Vacuole Postsynaptic Density Assembly ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Regulation Of TOR Signaling Glial Cell Development Postsynaptic Specialization Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Positive Regulation Of Catabolic Process Positive Regulation Of Proteolysis Transcription By RNA Polymerase I Intracellular Signaling Cassette Regulation Of Protein Metabolic Process Regulation Of Cell Size Schwann Cell Development Myelination Axon Ensheathment Cytosol Postsynaptic Density Organization Dendritic Spine Morphogenesis Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription ERBB2 Signaling Pathway Regulation Of Translational Initiation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Postsynaptic Specialization Organization Identical Protein Binding Secretory Granule Lumen Intracellular Signal Transduction Ficolin-1-rich Granule Lumen Nucleus Cytoplasm Positive Regulation Of RNA Metabolic Process Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Biosynthetic Process Response To Stress Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Positive Regulation Of Proteolysis Involved In Protein Catabolic Process	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein Modification Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Polyubiquitination Metal Ion Binding Macromolecule Catabolic Process Protein Metabolic Process Zinc Ion Binding Transferase Activity Proteolysis Endoplasmic Reticulum Mannose Trimming Response To Stress Macromolecule Metabolic Process Protein Alpha-1,2-demannosylation Catabolic Process Proteasomal Protein Catabolic Process Protein Deglycosylation Endoplasmic Reticulum Quality Control Compartment Protein K63-linked Ubiquitination Protein Catabolic Process ERAD Pathway Protein K48-linked Ubiquitination I-SMAD Binding Cellular Response To Stress Protein Destabilization Ubiquitin Activating Enzyme Activity Response To Endoplasmic Reticulum Stress Regulation Of Protein Stability Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Transforming Growth Factor Beta Receptor Activity, Type I Ubiquitin Protein Ligase Binding Aggresome Assembly Positive Regulation Of Macromolecule Metabolic Process SMAD Protein Complex Negative Regulation Of Mitochondrial Fusion Heteromeric SMAD Protein Complex Derlin-1 Retrotranslocation Complex Protein-containing Complex Binding Negative Regulation Of Type I Interferon Production Regulation Of Mitophagy Cytoplasm
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