CCT3 and ZNRD2

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
HPRD (two hybrid)

		CCT3	ZNRD2
Description		chaperonin containing TCP1 subunit 3	zinc ribbon domain containing 2
Image
GO Annotations	Cellular Component	Zona Pellucida Receptor Complex Cytoplasm Cytosol Chaperonin-containing T-complex Cytoskeleton Microtubule Cell Body Extracellular Exosome	Cytoplasm
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone	Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body	Mitotic Cell Cycle Cell Division
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester Artenimol
Diseases
GWAS		Basophil count ( 32888494) Glycated hemoglobin levels ( 24647736) Household income (MTAG) ( 31844048) Mean corpuscular hemoglobin concentration ( 20139978) Mean corpuscular volume ( 29403010) Red blood cell count ( 29403010) Red cell distribution width ( 32888494) Subcutaneous adipose tissue ( 22589738) Walking pace ( 33128006)	Glaucoma (primary open-angle) ( 33627673)
Interacting Genes		26 interacting genes: BUD31 CEBPA DEPDC5 EIF2B2 ERBB2 FANCA GEMIN4 HNRNPA0 HSPA8 LINC01554 LNX2 MAPK6 MIPOL1 OGT PAFAH1B2 POLR1C PTEN RAF1 SH3BP4 SHANK3 SUMO2 UBE2Z VAV2 VHL XRCC6 ZNRD2	28 interacting genes: ACTN2 CATSPERT CCDC33 CCNH CCT2 CCT3 CCT5 CCT7 FNDC11 FXR2 IL16 INCA1 MYO15B NME6 NOC4L PIAS2 POLA2 RNF115 RNF4 SNAPC5 STAT3 SUMO1P1 TRAF3IP3 TRAPPC6A UBC UBE2I VTA1 ZMYM5
Entrez ID		7203	10534
HPRD ID		08969	06921
Ensembl ID		ENSG00000163468	ENSG00000173465
Uniprot IDs		B3KX11 P49368 Q59H77	G3V1B8 O60232
PDB IDs		6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP 7NVL 7NVM 7NVN 7NVO 7TRG 7TTN 7TTT 7TUB 7WU7 7WZ3 7X0A 7X0S 7X0V 7X3J 7X3U 7X6Q 7X7Y 8HKI 8I1U 8I6J 8I9U 8IB8 8SFE 8SFF 8SG8 8SG9 8SGC 8SGL 8SGQ 8SH9 8SHA 8SHD 8SHE 8SHF 8SHG 8SHL 8SHN 8SHO 8SHP 8SHQ 8SHT	6HCZ
Enriched GO Terms of Interacting Partners?		Protein Localization To Lysosome Positive Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Protein Localization To Vacuole Postsynaptic Density Assembly ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Regulation Of TOR Signaling Glial Cell Development Postsynaptic Specialization Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Positive Regulation Of Catabolic Process Positive Regulation Of Proteolysis Transcription By RNA Polymerase I Intracellular Signaling Cassette Regulation Of Protein Metabolic Process Regulation Of Cell Size Schwann Cell Development Myelination Axon Ensheathment Cytosol Postsynaptic Density Organization Dendritic Spine Morphogenesis Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription ERBB2 Signaling Pathway Regulation Of Translational Initiation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Postsynaptic Specialization Organization Identical Protein Binding Secretory Granule Lumen Intracellular Signal Transduction Ficolin-1-rich Granule Lumen Nucleus Cytoplasm Positive Regulation Of RNA Metabolic Process Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Biosynthetic Process Response To Stress Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Positive Regulation Of Proteolysis Involved In Protein Catabolic Process	Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Binding Of Sperm To Zona Pellucida ATP-dependent Protein Folding Chaperone Sperm-egg Recognition Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Cell-cell Recognition Protein Folding Chaperone Positive Regulation Of Telomere Maintenance Cell Body Regulation Of DNA Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Chromosome Organization PML Body Regulation Of Telomere Maintenance Unfolded Protein Binding Protein Stabilization Regulation Of Chromosome Organization Cell Recognition Zona Pellucida Receptor Complex Protein Sumoylation Regulation Of Protein Localization To Nucleus Protein Tag Activity Regulation Of Protein Stability Protein Folding Transcription Factor Binding SUMO Transferase Activity Protein Modification By Small Protein Conjugation Positive Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Actin Filament Uncapping SUMO Conjugating Enzyme Activity RNA Polymerase II General Transcription Initiation Factor Activity Protein K11-linked Ubiquitination Post-translational Protein Modification Microtubule
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