HSP90B1 and MMP17

		HSP90B1	MMP17
Description		heat shock protein 90 beta family member 1	matrix metallopeptidase 17
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Cytosol Focal Adhesion Membrane Sarcoplasmic Reticulum Midbody Protein-containing Complex Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum Chaperone Complex Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome Endocytic Vesicle Lumen Sperm Plasma Membrane	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Matrix Side Of Membrane
	Molecular Function	Nucleotide Binding RNA Binding Protein Phosphatase Inhibitor Activity Calcium Ion Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Phosphatase Binding Protein Folding Chaperone Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding ATP-dependent Protein Folding Chaperone	Metalloendopeptidase Activity Enzyme Activator Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Response To Hypoxia Protein Folding Protein Transport Positive Regulation Of Wnt Signaling Pathway Retrograde Protein Transport, ER To Cytosol Actin Rod Assembly Positive Regulation Of Toll-like Receptor Signaling Pathway Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of Apoptotic Process Sequestering Of Calcium Ion Cellular Response To Manganese Ion Cellular Response To ATP Protein Localization To Plasma Membrane	Kidney Development Proteolysis Extracellular Matrix Organization Collagen Catabolic Process Drinking Behavior
Pathways		Trafficking and processing of endosomal TLR Scavenging by Class A Receptors Scavenging by Class A Receptors ATF6 (ATF6-alpha) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation	Activation of Matrix Metalloproteinases
Drugs		Rifabutin 2-Chlorodideoxyadenosine Geldanamycin Diglyme N-Ethyl-5'-Carboxamido Adenosine Radicicol METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE Copper	Marimastat
Diseases
GWAS		Metabolite levels ( 23823483) Soluble VCAM-1 levels ( 31217265)	Body mass index ( 26426971) Migraine ( 22683712) Psychosis proneness (perceptual aberration scale) ( 28525603)
Interacting Genes		42 interacting genes: APOB ASGR1 BIRC2 CACYBP CAMLG CSNK2A1 CSNK2A2 CYSLTR2 EGFR EPB41L4B ERBB2 ESR1 FANCC GPR37 GRIK1 HSPA13 HSPA9 LINC01554 LRP1 MAPK6 MDM2 MMP17 MTTP NKX3-1 NR5A2 OGT POLR2E PTEN PTPN11 PVT1 RNF10 RXFP3 SGTB SIRPA SUPT6H TG TLR1 TLR2 TLR4 TP53 TXNDC11 UBASH3A	5 interacting genes: HSP90B1 LRP1 MMP2 POLE TNF
Entrez ID		7184	4326
HPRD ID		01860	03793
Ensembl ID		ENSG00000166598	ENSG00000198598
Uniprot IDs		P14625 V9HWP2	Q9ULZ9
PDB IDs		4NH9 7ULL
Enriched GO Terms of Interacting Partners?		Receptor Complex Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Developmental Process Negative Regulation Of Proteolysis Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Metabolic Process Rhythmic Process Negative Regulation Of Developmental Process Negative Regulation Of Multicellular Organismal Process Animal Organ Development Heart Development Detection Of Molecule Of Bacterial Origin Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxygen-containing Compound Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Detection Of Triacyl Bacterial Lipopeptide Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Negative Regulation Of Cell Communication Negative Regulation Of Signaling Ubiquitin Protein Ligase Binding Regulation Of Intracellular Signal Transduction Lipoprotein Transport Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Protein Catabolic Process Regulation Of Interferon-beta Production Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase CK2 Complex Cellular Response To Actinomycin D Cellular Response To Triacyl Bacterial Lipopeptide Positive Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Regulation Of Protein Catabolic Process Negative Regulation Of Cell Differentiation Regulation Of Signal Transduction Response To Actinomycin D Detection Of Bacterial Lipoprotein Regulation Of Proteolysis ERBB Signaling Pathway Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Identical Protein Binding	Response To Amyloid-beta Regulation Of Amyloid-beta Clearance Astrocyte Activation Vascular Process In Circulatory System Circulatory System Process Cellular Response To Oxygen-containing Compound Response To Hypoxia Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Response To Nicotine Response To Oxygen Levels Response To Decreased Oxygen Levels Cellular Response To Amyloid-beta Positive Regulation Of Transcytosis Positive Regulation Of Protein Localization To Cell Periphery Alpha-2 Macroglobulin Receptor Activity Positive Regulation Of Protein Localization To Membrane Apolipoprotein Receptor Activity Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Amino Acid Stimulus Response To Activity Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis Cellular Response To Stress Response To Retinoic Acid Positive Regulation Of Reverse Cholesterol Transport Regulation Of Protein Localization To Plasma Membrane Regulation Of Transcytosis Response To Amino Acid Regeneration Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Negative Regulation Of L-glutamate Import Across Plasma Membrane Positive Regulation Of Fractalkine Production Positive Regulation Of Blood Microparticle Formation Response To Gold Nanoparticle Positive Regulation Of Vitamin D Biosynthetic Process Actin Rod Assembly Regulation Of Protein Localization To Cell Periphery Cell Activation Involved In Immune Response Lipoprotein Particle Receptor Binding Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Apoptotic Signaling Pathway Blood Vessel Diameter Maintenance Regulation Of Tube Size
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